2000
Regulation of DRA and AE1 in rat colon by dietary Na depletion
Rajendran V, Black J, Ardito T, Sangan P, Alper S, Schweinfest C, Kashgarian M, Binder H. Regulation of DRA and AE1 in rat colon by dietary Na depletion. AJP Gastrointestinal And Liver Physiology 2000, 279: g931-g942. PMID: 11052990, DOI: 10.1152/ajpgi.2000.279.5.g931.Peer-Reviewed Original Research
1990
Morphological and physiological responses to aldosterone: time course and sodium dependence
Wade J, Stanton B, Field M, Kashgarian M, Giebisch G. Morphological and physiological responses to aldosterone: time course and sodium dependence. American Journal Of Physiology 1990, 259: f88-f94. PMID: 2375395, DOI: 10.1152/ajprenal.1990.259.1.f88.Peer-Reviewed Original ResearchConceptsOsmotic minipumpsMale Sprague-Dawley ratsPrincipal cellsElevated aldosterone levelsSprague-Dawley ratsImplanted osmotic minipumpsTime courseBasolateral membraneAldosterone levelsIntravenous infusionAldosterone treatmentPhysiological elevationReplacement infusionsAldosteroneAcute exposureChronic exposureDetectable proliferationFurther elevationDays of exposureSodium dependenceBasolateral membrane areaMinipumpsInfusionSecretionExposure
1989
Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*
Rajendran V, Kashgarian M, Binder H. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*. Journal Of Biological Chemistry 1989, 264: 18638-18644. PMID: 2553716, DOI: 10.1016/s0021-9258(18)51514-3.Peer-Reviewed Original ResearchConceptsDistal colonRat distal colonNa-H exchangeElectrogenic sodium transportSodium transportExperimental ratsMicroM amilorideAmiloride-sensitive electrogenic sodium transportNormal rat distal colonEffects of aldosteroneElectroneutral sodium absorptionSodium concentrationApical membrane vesiclesAnalogues of amilorideVoltage-clamp conditionsDietary sodiumNormal ratsAldosterone inductionSodium absorptionColonComparable inhibitionRatsAmilorideAldosteronePotent inhibitor
1987
Response of collecting tubule cells to aldosterone and potassium loading
Kashgarian M, Ardito T, Hirsch D, Hayslett J. Response of collecting tubule cells to aldosterone and potassium loading. American Journal Of Physiology 1987, 253: f8-f14. PMID: 3605352, DOI: 10.1152/ajprenal.1987.253.1.f8.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCortical collecting tubuleBasolateral membrane surfaceCollecting tubuleChronic potassium loadingElevated levelsDuct structuresPotassium loadingSite of actionPlasma levelsRat modelOuter stripeInner stripeTubule cellsNormal physiological levelsControl valuesAldoMorphometric studyAldosteronePhysiological levelsDuct systemTubulesConcomitant changesDuct
1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissues
1973
The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets.
Domoto D, Boyd J, Mulrow P, Kashgarian M. The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets. American Journal Of Pathology 1973, 72: 433-46. PMID: 4728893, PMCID: PMC1904037.Peer-Reviewed Original ResearchConceptsSodium-deficient dietAldosterone productionPrincipal ultrastructural changesZona glomerulosa cellsAdrenal zona glomerulosaSodium-depleted animalsUltrastructural changesSodium-depleted dietGroups of animalsZona glomerulosaGlomerulosa cellsAdrenal cortexControl animalsMorphologic changesRatsSteroid synthesisMitochondrial changesDietAnimalsDaysInitial increaseGlomerulosaCortexCristae
1971
Accelerated reabsorption in the proximal tubule produced by volume depletion
Weiner M, Weinman E, Kashgarian M, Hayslett J. Accelerated reabsorption in the proximal tubule produced by volume depletion. Journal Of Clinical Investigation 1971, 50: 1379-1385. PMID: 5090054, PMCID: PMC292075, DOI: 10.1172/jci106620.Peer-Reviewed Original ResearchConceptsProximal tubulesFiltration rateVolume depletionIntrinsic reabsorptive capacitySodium-free dietGlomerular filtration rateProximal fluid reabsorptionAdministration of furosemideReabsorption of fluidTechnique of micropunctureAldosterone secretionRenal responseSodium depletionDistal tubulesReabsorptive capacityBody weightChronic depletionFluid reabsorptionMarked fallExtracellular volumePlasma volumeClinical phenomenaReabsorptionTubulesPresent experiments
1967
Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*
Hayslett J, Kashgarian M, Epstein F. Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*. Journal Of Clinical Investigation 1967, 46: 1254-1263. PMID: 6027087, PMCID: PMC297124, DOI: 10.1172/jci105618.Peer-Reviewed Original ResearchConceptsTubular reabsorptionTubular diameterDistal tubular reabsorptionGlomerular filtration rateProximal tubular reabsorptionAdministration of aldosteroneLoop of HenleAcute infusionFiltration rateRenal contentSaline infusionGlomerular filtrationSegments of tubulesIsotonic salineProximal tubulesExcretion of saltTubular flowReabsorptionExtracellular fluidInfusionTubulesInterstitial volumeRatsTransit timeAldosterone