2001
K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells
Eickelberg O, Geibel J, Seebach F, Giebisch G, Kashgarian M. K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells. American Journal Of Physiology. Renal Physiology 2001, 281: f280-f287. PMID: 11457719, DOI: 10.1152/ajprenal.2001.281.2.f280.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium Channel BlockersCell LineDiltiazemEgtazic AcidEnzyme InhibitorsEpithelial CellsGallic AcidGenes, ReporterHeat-Shock ProteinsHSP72 Heat-Shock ProteinsImmunoblottingKidney Tubules, ProximalMicroscopy, ConfocalPotassiumPromoter Regions, GeneticRecombinant Fusion ProteinsSodiumSwineThapsigarginUrotheliumConceptsHSP 72 expressionPromoter activityHSP 72Protein expressionProtective cellular responseLuciferase reporter geneHSP-25Heat shock protein expressionRenal epithelial cellsTranscriptional inductionShock protein expressionIonic stressReporter geneHSP-90 levelsHSC 73Cellular responsesChannel blocker diltiazemIntracellular lumenWestern blot analysisChelator EGTA-AMPathophysiological stimuliBlot analysisConfocal microscopyProtein levelsExtracellular space
1997
Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion
Sangan P, Rajendran V, Mann A, Kashgarian M, Binder H. Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion. American Journal Of Physiology 1997, 272: c685-c696. PMID: 9124313, DOI: 10.1152/ajpcell.1997.272.2.c685.Peer-Reviewed Original ResearchConceptsDietary K depletionDistal colonNA depletionK-ATPase activityProximal colonLarge intestineRat distal colonActive K absorptionK-ATPaseRenal collecting ductsDietary NaK-ATPase expressionK-ATPase isoformsK depletionRat colonCollecting ductsOuter medullaColonProtein expressionProtein levelsKidneyPolyclonal antibodiesIntestineDuctMRNA