Mechanism of change in the excretion of sodium per nephron when renal mass is reduced
Hayslett J, Kashgarian M, Epstein F. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Journal Of Clinical Investigation 1969, 48: 1002-1006. PMID: 5771184, PMCID: PMC322314, DOI: 10.1172/jci106056.Peer-Reviewed Original ResearchConceptsSodium excretionRenal tissueProximal tubular absorptionExcretion of sodiumHealthy nephronsPopulation of nephronsRenal insufficiencyRenal ablationRenal failureTubular absorptionRenal massesSodium balanceGlomerular filtrationDistal tubulesExcretionNephronOsmotic loadEarly adjustmentStepwise increaseMechanisms of changeTissueUninephrectomyHyperfiltrationInsufficiencyRats