1984
Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium
Stanton B, Biemesderfer D, Stetson D, Kashgarian M, Giebisch G. Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium. American Journal Of Physiology 1984, 247: c204-c216. PMID: 6476108, DOI: 10.1152/ajpcell.1984.247.3.c204.Peer-Reviewed Original ResearchConceptsEarly distal tubuleDistal tubulesDistal nephronPotassium adaptationRenal distal nephronLarge cell typeLate distal tubuleCortical collecting tubuleSmooth muscle cellsLate distalAfferent arteriolesEffects of exposureJuxtaglomerular apparatusMammalian cortical collecting tubuleCollecting tubuleEarly distalHenle's loopBasolateral membrane surface densityMuscle cellsPrincipal cellsCellular mechanismsNephronStereological techniquesTubulesUseful preparation
1982
The Ultrastructure of the Distal Tubule of Amphiuma: A Tem and Sem Study
Biemesderfer D, Stanton B, Kashgarian M, Giebisch G. The Ultrastructure of the Distal Tubule of Amphiuma: A Tem and Sem Study. Microscopy And Microanalysis 1982, 40: 170-171. DOI: 10.1017/s0424820100053541.Peer-Reviewed Original Research
1980
Chapter 10 Changes in Cell Membrane Surfaces Associated with Alterations of Transepithelial Ion Movement
Kashgarian M. Chapter 10 Changes in Cell Membrane Surfaces Associated with Alterations of Transepithelial Ion Movement. Current Topics In Membranes 1980, 13: 149-160. DOI: 10.1016/s0070-2161(08)60278-6.Peer-Reviewed Original ResearchDistal colonPotassium adaptationAcute potassium loadBiochemical changesGroups of animalsPotassium intakePotassium loadMineralocorticoid levelsChapter 10 ChangesProximal colonDistal tubulesSampling of cellsGreater passive permeabilityGlucocorticoid levelsMechanism of inductionEnhanced excretionMorphometric quantitationMembrane changesOrgan systemsColonDifferent physiologic statesUnadapted animalsBasolateral membrane surfaceEnhanced abilityPhysiologic state
1979
A micropuncture study of the renal handling of lithium
Hayslett J, Kashgarian M. A micropuncture study of the renal handling of lithium. Pflügers Archiv - European Journal Of Physiology 1979, 380: 159-163. PMID: 573443, DOI: 10.1007/bf00582152.Peer-Reviewed Original ResearchConceptsMicropuncture studiesProximal tubulesLoop of HenleTubular fluid samplesNephron sitesNet transepithelial movementRenal handlingLithium reabsorptionDistal tubulesClearance studiesTubular fluidProximal convolutionExperimental animalsDistal portionFluid samplesTubulesTransepithelial movementHenleNephron
1978
Effects of potassium depletion on renal tubular chloride transport in the rat
Luke R, Wright F, Fowler N, Kashgarian M, Giebisch G. Effects of potassium depletion on renal tubular chloride transport in the rat. Kidney International 1978, 14: 414-427. PMID: 35645, DOI: 10.1038/ki.1978.146.Peer-Reviewed Original ResearchConceptsEarly distal tubuleLoop of HenleDistal tubulesKD groupChloride reabsorptionProximal tubulesPotassium depletionAbsolute chloride reabsorptionAdministration of DOCASingle nephron GFRRenal tubular reabsorptionPotassium-depleted ratsLate distal tubuleEffects of KDNephron GFRTubular reabsorptionChloride intakeFractional reabsorptionClearance studiesDay 2Fractional deliveryMuscle potassiumWhole kidneyDay 9RatsMicropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney
Hecht B, Kashgarian M, Forrest J, Hayslett J. Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney. Pflügers Archiv - European Journal Of Physiology 1978, 377: 69-74. PMID: 569282, DOI: 10.1007/bf00584376.Peer-Reviewed Original ResearchConceptsFractional reabsorptionDistal tubule functionProximal fractional reabsorptionPlasma lithium concentrationReabsorption of bicarbonateMultiple nephron segmentsEnd-proximal tubuleEffects of lithiumLithium treatmentPotassium secretionAntidiuretic hormoneDistal tubulesMicropuncture studiesTubule functionProximal tubulesDistal convolutionExperimental animalsNephron segmentsReabsorptionDistal portionTubulesPrevious studiesRatsSodiumHormone
1977
Electrical characteristics of the mammalian distal tubule: Comparison of Ling-Gerard and macroelectrodes
Hayslett J, Boulpaep E, Kashgarian M, Giebisch G. Electrical characteristics of the mammalian distal tubule: Comparison of Ling-Gerard and macroelectrodes. Kidney International 1977, 12: 324-331. PMID: 604621, DOI: 10.1038/ki.1977.119.Peer-Reviewed Original Research
1971
Accelerated reabsorption in the proximal tubule produced by volume depletion
Weiner M, Weinman E, Kashgarian M, Hayslett J. Accelerated reabsorption in the proximal tubule produced by volume depletion. Journal Of Clinical Investigation 1971, 50: 1379-1385. PMID: 5090054, PMCID: PMC292075, DOI: 10.1172/jci106620.Peer-Reviewed Original ResearchConceptsProximal tubulesFiltration rateVolume depletionIntrinsic reabsorptive capacitySodium-free dietGlomerular filtration rateProximal fluid reabsorptionAdministration of furosemideReabsorption of fluidTechnique of micropunctureAldosterone secretionRenal responseSodium depletionDistal tubulesReabsorptive capacityBody weightChronic depletionFluid reabsorptionMarked fallExtracellular volumePlasma volumeClinical phenomenaReabsorptionTubulesPresent experiments
1969
Mechanism of change in the excretion of sodium per nephron when renal mass is reduced
Hayslett J, Kashgarian M, Epstein F. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Journal Of Clinical Investigation 1969, 48: 1002-1006. PMID: 5771184, PMCID: PMC322314, DOI: 10.1172/jci106056.Peer-Reviewed Original ResearchConceptsSodium excretionRenal tissueProximal tubular absorptionExcretion of sodiumHealthy nephronsPopulation of nephronsRenal insufficiencyRenal ablationRenal failureTubular absorptionRenal massesSodium balanceGlomerular filtrationDistal tubulesExcretionNephronOsmotic loadEarly adjustmentStepwise increaseMechanisms of changeTissueUninephrectomyHyperfiltrationInsufficiencyRats
1968
Functional correlates of compensatory renal hypertrophy
Hayslett J, Kashgarian M, Epstein F. Functional correlates of compensatory renal hypertrophy. Journal Of Clinical Investigation 1968, 47: 774-782. PMID: 5641618, PMCID: PMC297228, DOI: 10.1172/jci105772.Peer-Reviewed Original Research