1981
Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion
Siegel N, Upadhyaya K, Kashgarian M. Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion. Kidney International 1981, 20: 691-694. PMID: 7334741, DOI: 10.1038/ki.1981.197.Peer-Reviewed Original ResearchConceptsUnilateral ureteral occlusionBilateral ureteral occlusionContralateral kidneyUreteral occlusionRenal functionAdaptive changesCompensatory changesObstructive renal injuryInfusion of indomethacinRelease of obstructionRenal hemodynamicsRenal injuryPattern of recoveryObstructive nephropathyPathophysiologic alterationsRenal massesUnoperated kidneysKidneyOcclusionAdaptive alterationsHemodynamicsControl organsIndomethacinAlterationsPresent study
1980
Renal perfusion and intratubular pressure during ureteral occlusion in the rat
Gaudio K, Siegel N, Hayslett J, Kashgarian M. Renal perfusion and intratubular pressure during ureteral occlusion in the rat. American Journal Of Physiology 1980, 238: f205-f209. PMID: 7369362, DOI: 10.1152/ajprenal.1980.238.3.f205.Peer-Reviewed Original ResearchConceptsTotal renal blood flowBilateral ureteral occlusionBody wt-1Tubular hydrostatic pressureUreteral occlusionKidney 1WT-1Renal blood flowRenal hemodynamicsRenal perfusionIntratubular pressureBlood flowControl animalsSustained increasePeak riseOcclusionMmHgIndomethacinSubsequent time intervalsRatsPatterns of changeAlterationsAnimalsPrimary roleSubsequent time periods
1977
RENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION
Siegel N, Gunatream S, Kashgarian M. RENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION. Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01125.Peer-Reviewed Original ResearchRenal blood flowGlomerular perfusionUreteral occlusionSuperficial cortexBlood flowObstructive nephropathyTotal renal blood flowBilateral ureteral occlusionRadioactive microsphere techniqueSham operated control animalsGlomerular hypoperfusionCortical ischemiaOperated control animalsCortical perfusionRenal injuryComplete ureteral occlusionMicrosphere techniqueSham operationControl animalsDeep cortexPerfusionControl valuesGlomerular countCortexOcclusionRenal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathy