2023
Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2. Anesthesia & Analgesia 2023, 137: 26-47. PMID: 37326862, DOI: 10.1213/ane.0000000000006506.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnalgesics, OpioidCardiac Surgical ProceduresHumansOpioid-Related DisordersPain ManagementPain, PostoperativeConceptsIntraoperative pain managementCardiac surgical patientsCardiac surgeryPain managementPractice advisorySurgical patientsEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPain management strategiesCardiac surgical proceduresPreoperative patient evaluationMeaningful patient outcomesHealth care costsAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesSurgical proceduresPractice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1. Anesthesia & Analgesia 2023, 137: 2-25. PMID: 37079466, DOI: 10.1213/ane.0000000000006441.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnalgesics, OpioidHumansOpioid-Related DisordersPain ManagementPain, PostoperativeThoracic Surgical ProceduresConceptsIntraoperative pain managementThoracic surgical patientsPain managementThoracic surgerySurgical patientsPractice advisoryEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPersistent postoperative painPain management strategiesPreoperative patient evaluationRelevant patient outcomesThoracic surgical proceduresAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPostoperative painPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesPain management and opioid stewardship in adult cardiac surgery: Joint consensus report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society
Grant M, Chappell D, Gan T, Manning M, Miller T, Brodt J, Workgroup P, Shaw A, Engelman D, Mythen M, Guinn N, Aronson S, Schwartz J, Arora R, Morton-Bailey V, Brudney C, Bennett-Guerrero E, Reddy V, Guzzi L, Brown J, Crisafi C. Pain management and opioid stewardship in adult cardiac surgery: Joint consensus report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Journal Of Thoracic And Cardiovascular Surgery 2023, 166: 1695-1706.e2. PMID: 36868931, DOI: 10.1016/j.jtcvs.2023.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidCardiac Surgical ProceduresConsensusEnhanced Recovery After SurgeryHumansPain ManagementPain, PostoperativeConceptsCardiac surgery patientsEnhanced recovery programmeHigh-dose opioidsOpioid stewardshipSurgery patientsPain managementCardiac surgeryNonopioid medicationsProvider educationOpioid prescription practicesCardiac surgery populationOptimal pain managementRole of opioidsAdult cardiac surgeryRegional anesthesia techniquesLevel of evidencePotential side effectsOptimal analgesiaOpioid administrationSurgery populationOpioid usePerioperative carePrescription practicesAnesthesia techniquesConsensus recommendations
2022
Regional analgesia for cardiac surgery
Grant M, Gregory A, Ouanes J. Regional analgesia for cardiac surgery. Current Opinion In Anaesthesiology 2022, 35: 605-612. PMID: 35900740, DOI: 10.1097/aco.0000000000001169.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesiaAnalgesics, OpioidCardiac Surgical ProceduresHumansPain ManagementPain, PostoperativeConceptsCardiac surgeryRegional analgesiaRegional techniquesCardiac surgical settingChest wall blocksOpioid-sparing analgesiaOpioid-sparing approachPain management expertsPerioperative patient careOpioid requirementsOpioid administrationPain controlPain managementPerioperative carePatients' qualityRegional anesthesiaAnalgesiaSurgical settingSurgeryPatient careCareAnesthesiaAdministrationInvestigating Opioid-Free Analgesia—Practice Makes Perfect
Grant M. Investigating Opioid-Free Analgesia—Practice Makes Perfect. JAMA Network Open 2022, 5: e2221441. PMID: 35849402, DOI: 10.1001/jamanetworkopen.2022.21441.Peer-Reviewed Original ResearchSituational Awareness of Opioid Consumption: The Missing Link to Reducing Dependence After Surgery?
Engelman D, Crisafi C, Hodle T, Stiles J, Nathanson B, Zarbock A, Grant M. Situational Awareness of Opioid Consumption: The Missing Link to Reducing Dependence After Surgery? Anesthesia & Analgesia 2022, 135: 653-658. PMID: 35110517, DOI: 10.1213/ane.0000000000005923.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidAwarenessHumansOpioid-Related DisordersPain ManagementPain, PostoperativePractice Patterns, Physicians'Retrospective Studies
2020
Perioperative methadone prescribing and association with respiratory depression.
Bova S, Kruer R, Nesbit S, Grant M, Jarrell A. Perioperative methadone prescribing and association with respiratory depression. Journal Of Opioid Management 2020, 16: 443-449. PMID: 33428191, DOI: 10.5055/jom.2020.0602.Peer-Reviewed Original ResearchConceptsPercent of patientsRespiratory depressionMethadone useMethadone initiationMethadone dosingRisk factorsPost-operative respiratory depressionAcute post-operative painSingle academic medical centerInadequate pain controlPost-operative painPost-operative dayAcademic medical centerAnalgesia managementChronic opioidsPain controlAdult patientsBaseline characteristicsCohort studyMost patientsSurgery patientsAdult inpatientsSingle centerMale sexMedical recordsOpioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery.
Grant M, Isada T, Ruzankin P, Gottschalk A, Whitman G, Lawton J, Dodd-O J, Barodka V. Opioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery. Anesthesia & Analgesia 2020, 131: 1852-1861. PMID: 32889848, DOI: 10.1213/ane.0000000000005152.Peer-Reviewed Original ResearchConceptsIntraoperative opioid administrationEnhanced recovery programmeOpioid administrationCardiac surgeryNonopioid interventionsPostoperative outcomesNumber of interventionsOpioid patientsSecondary analysisSerratus anterior plane blockMorphine sulfate equivalentsOpioid-sparing strategiesPostoperative pain scoresFuture prospective studiesLength of stayLinear mixed-effects regression modelsMixed-effects regression modelsIntraoperative dexmedetomidineLower opioidPreoperative gabapentinMultimodal analgesiaPain scoresPostoperative complicationsOpioid usePlane blockNew Persistent Opioid Use After Aortic and Mitral Valve Surgery in Commercially Insured Patients
Clement K, Canner J, Whitman G, Lawton J, Grant M, Sussman M. New Persistent Opioid Use After Aortic and Mitral Valve Surgery in Commercially Insured Patients. The Annals Of Thoracic Surgery 2020, 110: 829-835. PMID: 32004502, DOI: 10.1016/j.athoracsur.2019.12.031.Peer-Reviewed Original ResearchConceptsNew persistent opioid usePersistent opioid useAortic valve replacementMitral valve replacementMitral valve repairOpioid-naive patientsMitral valve surgeryOpioid useValve replacementValve repairOpioid prescriptionsValve surgeryPerioperative periodRisk factorsMitral valve replacement/repairValve replacement/repairMultivariable logistic regressionHealthcare paymentsTotal healthcare paymentsReplacement/repairOpioid prescribingPrescription opioidsCostly complicationEmergency departmentPatients
2019
Predictors of new persistent opioid use after coronary artery bypass grafting
Clement K, Canner J, Lawton J, Whitman G, Grant M, Sussman M. Predictors of new persistent opioid use after coronary artery bypass grafting. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 954-963.e4. PMID: 32007246, DOI: 10.1016/j.jtcvs.2019.09.137.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAmbulatory CareAnalgesics, OpioidCoronary Artery BypassDatabases, FactualDrug Administration ScheduleDrug PrescriptionsFemaleHumansMaleMiddle AgedOpioid-Related DisordersPain, PostoperativePractice Patterns, Physicians'Retrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsNew persistent opioid usePersistent opioid useCoronary artery bypassArtery bypassOpioid useOpioid prescriptionsPerioperative periodNaïve patientsChronic obstructive pulmonary diseaseAmount of opioidsAppropriate opioid prescribingObstructive pulmonary diseaseMultivariable logistic regressionPrescription opioid overdosePrior substance abuseInsurance claims dataOpioid requirementsOutpatient opioidsOpioid prescribingCardiac surgeryPulmonary diseaseOpioid dependenceProspective studyRisk factorsFemale genderOpioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery
Owodunni O, Zaman M, Ighani M, Grant M, Bettick D, Sateri S, Magnuson T, Gearhart S. Opioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery. Surgery 2019, 166: 1055-1060. PMID: 31526584, DOI: 10.1016/j.surg.2019.08.001.Peer-Reviewed Original ResearchConceptsEnhanced recovery pathwayMajor abdominal surgeryOpioid-tolerant patientsOpioid toleranceAbdominal surgeryLength of stayTolerant patientsRecovery pathwaysPostoperative outcomesMajor complicationsPathway complianceChallenging patient cohortNon-tolerant patientsPoor postoperative outcomesOperative Severity ScoreEnUmeration of MortalityRisk-adjusted analysisPrescribed opioid medicationsOutcomes of interestEvidence-based interventionsColorectal PhysiologicalOral morphineOpioid medicationsEmergency surgeryReadmission ratesAmerican Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy
Edwards D, Hedrick T, Jayaram J, Argoff C, Gulur P, Holubar S, Gan T, Mythen M, Miller T, Shaw A, Thacker J, McEvoy M, Geiger T, Gordon D, Grant M, Grocott M, Gupta R, Hah J, Hurley R, Kent M, King A, Oderda G, Sun E, Wu C. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30768461, DOI: 10.1213/ane.0000000000004018.Peer-Reviewed Original ResearchConceptsOpioid-related complicationsPerioperative managementConsensus recommendationsPerioperative Quality Initiative Joint Consensus StatementJoint consensus statementPerioperative treatment strategiesChronic opioid useHigh-risk groupPathways of careStandard of careHealth care providersHealth care teamOpioid therapyPreoperative opioidsMultimodal analgesiaPerioperative outcomesOpioid usePain specialistsRisk patientsCare management practicesElective surgeryFree anesthesiaOpioid dependenceRisk stratificationCare teamAmerican Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients.
Wu C, King A, Geiger T, Grant M, Grocott M, Gupta R, Hah J, Miller T, Shaw A, Gan T, Thacker J, Mythen M, McEvoy M. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients. Anesthesia & Analgesia 2019, 129: 567-577. PMID: 31082966, PMCID: PMC7261519, DOI: 10.1213/ane.0000000000004194.Peer-Reviewed Original ResearchConceptsPersistent postoperative opioid useOpioid-naïve patientsPostoperative opioid useOpioid-free anesthesiaOpioid useOpioid minimizationPerioperative Quality Initiative Joint Consensus StatementNew persistent postoperative opioid useJoint consensus statementOpioid-based medicationsPerioperative opioid useEnhanced recovery pathwayQuality InitiativePerioperative periodPain interventionsConsensus statementConsensus recommendationsSurgical careConsensus documentEnhanced recoverySuperior outcomesRecovery pathwaysDelphi processAmerican SocietyAnesthesia
2018
Perioperative Esmolol and Opioids
Grant M, Ouanes J, Joshi B. Perioperative Esmolol and Opioids. Regional Anesthesia & Pain Medicine 2018, 43: 813-814. PMID: 30339612, DOI: 10.1097/aap.0000000000000877.Peer-Reviewed Original ResearchIn Response
Stone A, Wu C, Grant M. In Response. Anesthesia & Analgesia 2018, 127: 319-320. PMID: 29757777, DOI: 10.1213/ane.0000000000003404.Peer-Reviewed Original ResearchAnalgesics, OpioidLabeling Morphine Milligram Equivalents on Opioid Packaging: a Potential Patient Safety Intervention
Stone A, Urman R, Kaye A, Grant M. Labeling Morphine Milligram Equivalents on Opioid Packaging: a Potential Patient Safety Intervention. Current Pain And Headache Reports 2018, 22: 46. PMID: 29855852, DOI: 10.1007/s11916-018-0695-3.Peer-Reviewed Original ResearchConceptsMorphine Milligram EquivalentsPain treatment settingsSpecific patient populationsPurpose of ReviewGivenPatient safety interventionsEquianalgesic conversionsOpioid strengthPrescriber errorsOpioid prescriptionsPrescribed opioidsChronic painPalliative careAdverse outcomesPatient populationOpioid abuseOverdose deathsUS FoodDrug AdministrationTreatment settingsHealthcare qualityOpioidsPatientsSafety interventionsPotential strategyPrimary causeReply to Dr Tran et al
Stone A, Wu C, Grant M. Reply to Dr Tran et al. Regional Anesthesia & Pain Medicine 2018, 43: 450-451. PMID: 29668663, DOI: 10.1097/aap.0000000000000787.Peer-Reviewed Original ResearchShould Hospitals Market Opioid-Sparing Analgesia to Patients?
Stone A, Wu C, Grant M. Should Hospitals Market Opioid-Sparing Analgesia to Patients? Regional Anesthesia & Pain Medicine 2018, 43: 2-4. PMID: 29140958, DOI: 10.1097/aap.0000000000000691.Peer-Reviewed Original ResearchAnalgesics, Non-NarcoticAnalgesics, OpioidCombined Modality TherapyDirect-to-Consumer AdvertisingHealth Knowledge, Attitudes, PracticeHospitalsHumansMarketing of Health ServicesOpioid-Related DisordersPain ManagementPatient Acceptance of Health CarePatient Education as TopicPatient SafetyRisk FactorsUnited States
2017
The US Opioid Crisis
Stone A, Wick E, Wu C, Grant M. The US Opioid Crisis. Anesthesia & Analgesia 2017, 125: 1803-1805. PMID: 28678072, DOI: 10.1213/ane.0000000000002236.Peer-Reviewed Original ResearchPostoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review
Wick E, Grant M, Wu C. Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review. JAMA Surgery 2017, 152: 691-697. PMID: 28564673, DOI: 10.1001/jamasurg.2017.0898.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory agentsAnti-inflammatory agentsERAS pathwayPostoperative bleedingN-methyl-D-aspartate (NMDA) classMultimodal analgesia approachGlutamate receptor antagonistsCurrent opioid epidemicComplex surgical proceduresAnalgesic regimensOpioid consumptionLess opioidsMultimodal analgesiaNarcotic analgesiaNonopioid analgesicsHospital dischargeMost patientsPain managementRegional analgesiaSurgery pathwayReceptor antagonistClinical trialsOpioid epidemicEffective adjunctSurgical care