2023
Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Mendez-Pino L, Urman R, Varelmann D. Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1734-1743. PMID: 37330329, DOI: 10.1053/j.jvca.2023.05.035.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansLungLung DiseasesPostoperative ComplicationsRespiration DisordersRetrospective StudiesRisk FactorsConceptsPostoperative pulmonary complicationsLung resection surgeryRisk-scoring systemPulmonary complicationsResection surgeryScoring systemLung resectionRisk scoreRisk of PPCsRetrospective cohort study SETTINGLAS VEGASAlternative risk scoresSingle-center cohortCohort study SETTINGAdult patientsExpiratory volumeLung surgeryThoracic surgeryPulmonary riskConcordance indexSurgeryPatientsDiscriminatory powerStudy settingComplicationsEfficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations
Grant M, Aredo J, Starrett J, Stockhammer P, van Rosenburgh I, Wurtz A, Piper-Valillo A, Piotrowska Z, Falcon C, Yu H, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li F, Neal J, Lemmon M, Walther Z, Politi K, Goldberg S. Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations. Clinical Cancer Research 2023, 29: of1-of8. PMID: 36913537, PMCID: PMC10493186, DOI: 10.1158/1078-0432.ccr-22-3497.Peer-Reviewed Original ResearchMeSH KeywordsAniline CompoundsCarcinoma, Non-Small-Cell LungErbB ReceptorsExonsHumansLung NeoplasmsMutationProtein Kinase InhibitorsRetrospective StudiesSequence DeletionConceptsProgression-free survivalNon-small cell lung cancerInferior progression-free survivalMulticenter retrospective cohortEfficacy of osimertinibMulti-institutional cohortCell lung cancerExon 19 deletion mutationUncommon EGFRRetrospective cohortClinical outcomesClinical efficacyLung cancerOsimertinib efficacyEGFR mutationsPreclinical modelsEx19delPatientsAACR Genie databaseLater linesOsimertinibMutant cohortFirst lineCohortEfficacy
2022
Situational Awareness of Opioid Consumption: The Missing Link to Reducing Dependence After Surgery?
Engelman D, Crisafi C, Hodle T, Stiles J, Nathanson B, Zarbock A, Grant M. Situational Awareness of Opioid Consumption: The Missing Link to Reducing Dependence After Surgery? Anesthesia & Analgesia 2022, 135: 653-658. PMID: 35110517, DOI: 10.1213/ane.0000000000005923.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidAwarenessHumansOpioid-Related DisordersPain ManagementPain, PostoperativePractice Patterns, Physicians'Retrospective Studies
2021
Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery
Metkus T, Thibault D, Grant M, Badhwar V, Jacobs J, Lawton J, O'Brien S, Thourani V, Wegermann Z, Zwischenberger B, Higgins R. Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery. Journal Of The American College Of Cardiology 2021, 78: 112-122. PMID: 33957241, PMCID: PMC8876254, DOI: 10.1016/j.jacc.2021.04.064.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, TransesophagealHumansMiddle AgedPostoperative ComplicationsRetrospective StudiesUnited StatesConceptsIntraoperative transesophageal echocardiographyHigh-risk patientsTransesophageal echocardiographyCABG patientsOperative mortalityValve proceduresCoronary artery bypass graft surgeryThoracic Surgeons Adult Cardiac Surgery DatabaseArtery bypass graft surgeryAdult Cardiac Surgery DatabasePost-CABG mortalityBypass graft surgeryCoronary artery bypassRetrospective cohort studyLow operative mortalityPercentage of patientsCardiac Surgery DatabaseClinical decision makingArtery bypassGraft surgeryValve surgeryCohort studyCABG proceduresPrimary outcomeSurgery Database
2020
Perioperative methadone prescribing and association with respiratory depression.
Bova S, Kruer R, Nesbit S, Grant M, Jarrell A. Perioperative methadone prescribing and association with respiratory depression. Journal Of Opioid Management 2020, 16: 443-449. PMID: 33428191, DOI: 10.5055/jom.2020.0602.Peer-Reviewed Original ResearchConceptsPercent of patientsRespiratory depressionMethadone useMethadone initiationMethadone dosingRisk factorsPost-operative respiratory depressionAcute post-operative painSingle academic medical centerInadequate pain controlPost-operative painPost-operative dayAcademic medical centerAnalgesia managementChronic opioidsPain controlAdult patientsBaseline characteristicsCohort studyMost patientsSurgery patientsAdult inpatientsSingle centerMale sexMedical recordsNew Persistent Opioid Use After Aortic and Mitral Valve Surgery in Commercially Insured Patients
Clement K, Canner J, Whitman G, Lawton J, Grant M, Sussman M. New Persistent Opioid Use After Aortic and Mitral Valve Surgery in Commercially Insured Patients. The Annals Of Thoracic Surgery 2020, 110: 829-835. PMID: 32004502, DOI: 10.1016/j.athoracsur.2019.12.031.Peer-Reviewed Original ResearchConceptsNew persistent opioid usePersistent opioid useAortic valve replacementMitral valve replacementMitral valve repairOpioid-naive patientsMitral valve surgeryOpioid useValve replacementValve repairOpioid prescriptionsValve surgeryPerioperative periodRisk factorsMitral valve replacement/repairValve replacement/repairMultivariable logistic regressionHealthcare paymentsTotal healthcare paymentsReplacement/repairOpioid prescribingPrescription opioidsCostly complicationEmergency departmentPatients
2019
Predictors of new persistent opioid use after coronary artery bypass grafting
Clement K, Canner J, Lawton J, Whitman G, Grant M, Sussman M. Predictors of new persistent opioid use after coronary artery bypass grafting. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 954-963.e4. PMID: 32007246, DOI: 10.1016/j.jtcvs.2019.09.137.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAmbulatory CareAnalgesics, OpioidCoronary Artery BypassDatabases, FactualDrug Administration ScheduleDrug PrescriptionsFemaleHumansMaleMiddle AgedOpioid-Related DisordersPain, PostoperativePractice Patterns, Physicians'Retrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsNew persistent opioid usePersistent opioid useCoronary artery bypassArtery bypassOpioid useOpioid prescriptionsPerioperative periodNaïve patientsChronic obstructive pulmonary diseaseAmount of opioidsAppropriate opioid prescribingObstructive pulmonary diseaseMultivariable logistic regressionPrescription opioid overdosePrior substance abuseInsurance claims dataOpioid requirementsOutpatient opioidsOpioid prescribingCardiac surgeryPulmonary diseaseOpioid dependenceProspective studyRisk factorsFemale genderOpioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery
Owodunni O, Zaman M, Ighani M, Grant M, Bettick D, Sateri S, Magnuson T, Gearhart S. Opioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery. Surgery 2019, 166: 1055-1060. PMID: 31526584, DOI: 10.1016/j.surg.2019.08.001.Peer-Reviewed Original ResearchConceptsEnhanced recovery pathwayMajor abdominal surgeryOpioid-tolerant patientsOpioid toleranceAbdominal surgeryLength of stayTolerant patientsRecovery pathwaysPostoperative outcomesMajor complicationsPathway complianceChallenging patient cohortNon-tolerant patientsPoor postoperative outcomesOperative Severity ScoreEnUmeration of MortalityRisk-adjusted analysisPrescribed opioid medicationsOutcomes of interestEvidence-based interventionsColorectal PhysiologicalOral morphineOpioid medicationsEmergency surgeryReadmission ratesOn‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study
Cho B, Jung Y, DeMario V, Lau E, Podlasek S, Grant M, Gehrie E, Frank S. On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study. Transfusion 2019, 59: 2678-2684. PMID: 31121073, DOI: 10.1111/trf.15355.Peer-Reviewed Original ResearchConceptsUrgent reversalLabel useMortality rateFour-factor prothrombin complex concentrateAcute major bleedingVitamin K antagonistsProthrombin complex concentrate useProthrombin complex concentrateOff-label useCoagulation factor deficienciesHospital mortalityMajor bleedingK antagonistsPatient characteristicsClinical outcomesBlood utilizationExpensive treatment optionsLabel indicationsSingle institutionTreatment optionsComplex concentrateObservational studyFactor deficiencyInvasive proceduresOff labelDischarge Hemoglobin Level and 30-Day Readmission Rates After Coronary Artery Bypass Surgery
Cho B, DeMario V, Grant M, Hensley N, Brown C, Hebbar S, Mandal K, Whitman G, Frank S. Discharge Hemoglobin Level and 30-Day Readmission Rates After Coronary Artery Bypass Surgery. Anesthesia & Analgesia 2019, 128: 342-348. PMID: 30059402, PMCID: PMC6533067, DOI: 10.1213/ane.0000000000003671.Peer-Reviewed Original ResearchConceptsDischarge Hb levelsDischarge hemoglobin levelsReadmission ratesHb levelsPatient characteristicsHemoglobin levelsMultivariable analysisBlood utilizationCoronary artery bypass surgeryCertain patient comorbiditiesRestrictive transfusion strategyCharlson Comorbidity IndexCoronary artery bypassArtery bypass surgeryLarge randomized trialsRisk-adjusted oddsSimilar patient characteristicsLow Hb levelsCABG patientsDischarge HbPreoperative comorbiditiesArtery bypassComorbidity indexBypass surgeryPatient comorbidities
2018
Early ambulation after colorectal oncologic resection with perineal reconstruction is safe and effective
Calotta N, Coon D, Bos T, Ostrander B, Scott A, Grant M, Efron J, Sacks J. Early ambulation after colorectal oncologic resection with perineal reconstruction is safe and effective. The American Journal Of Surgery 2018, 218: 125-130. PMID: 30471809, DOI: 10.1016/j.amjsurg.2018.10.005.Peer-Reviewed Original ResearchConceptsEarly ambulationPerineal reconstructionOncologic resectionPost-operative day oneEarly ambulation protocolRetrospective cohort studyMinor complication rateStandard of careOncological surgery patientsAmbulation capacityWound complicationsCohort studySurgery patientsComplication rateSurgical outcomesReconstructive outcomesAmbulationMore ambulatoryBedrestDay oneReoperationReadmissionResectionSignificant differencesPatients
2017
Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery
Grant MC, Hanna A, Benson A, Hobson D, Wu CL, Yuan CT, Rosen M, Wick EC. Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery. Journal Of The American College Of Surgeons 2017, 226: 267-276. PMID: 29274837, DOI: 10.1016/j.jamcollsurg.2017.12.010.Peer-Reviewed Original ResearchConceptsClinical outcomesProcess measure complianceEnhanced recoveryMeasure complianceOperating room teamSurgery programAnesthesia providersSurgical site infectionLength of stayHigh complianceColorectal surgeryERAS implementationERAS programSite infectionPerioperative careSurgery pathwayProvider teamProtocol elementsNurse anesthetistsIndividual providersDedicated teamOutcomesSignificant increaseSignificant reductionAnesthesiologistsOptimizing an Enhanced Recovery Pathway Program: Development of a Postimplementation Audit Strategy
Grant M, Galante D, Hobson D, Lavezza A, Friedman M, Wu C, Wick E. Optimizing an Enhanced Recovery Pathway Program: Development of a Postimplementation Audit Strategy. The Joint Commission Journal On Quality And Patient Safety 2017, 43: 524-533. PMID: 28942777, DOI: 10.1016/j.jcjq.2017.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersClinical ProtocolsDigestive System Surgical ProceduresElectronic Health RecordsFemaleGroup ProcessesHumansLength of StayMaleMiddle AgedOrganizational CulturePatient Care BundlesPatient Care TeamPerioperative CarePostoperative ComplicationsQuality Indicators, Health CareRetrospective StudiesSafety ManagementConceptsLength of stayOverall LOSAverage LOSProcess measuresThree-month followProcess measure complianceAcademic medical centerSystem-level interventionsSignificant reductionElectronic health recordsColorectal surgeryConsecutive patientsPathway implementationEarly mobilityMeasure complianceMedical CenterPreventable harmOne-year periodPatientsRecovery pathwaysHealth recordsSystem-level changesSurgeryComplianceSame procedureIs enhanced recovery enough for reducing 30-d readmissions after surgery?
Fabrizio A, Grant M, Siddiqui Z, Alimi Y, Gearhart S, Wu C, Efron J, Wick E. Is enhanced recovery enough for reducing 30-d readmissions after surgery? Journal Of Surgical Research 2017, 217: 45-53. PMID: 28602223, DOI: 10.1016/j.jss.2017.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColorectal SurgeryFemaleHumansMaleMiddle AgedPatient ReadmissionPerioperative CareRetrospective StudiesYoung AdultConceptsEnhanced recovery pathwaySurgical site infectionSite infectionSingle tertiary care centerPostoperative surgical site infectionIndex hospitalization lengthTertiary care centerEnhanced recovery programmeLength of stayTransitions of carePatient care experiencesColorectal surgeryReadmission ratesReduced readmissionsHospitalization lengthRetrospective studyCare transitionsCare centerPatient outcomesReadmissionSymptom monitoringSimilar cohortEnhanced recoveryHome transfersCare experiencesThoracic Epidural Anesthesia and Prophylactic Three Times Daily Unfractionated Heparin Within an Enhanced Recovery After Surgery Pathway for Colorectal Surgery
Stone A, Grant M, Lau B, Hobson D, Streiff M, Haut E, Wu C, Wick E. Thoracic Epidural Anesthesia and Prophylactic Three Times Daily Unfractionated Heparin Within an Enhanced Recovery After Surgery Pathway for Colorectal Surgery. Regional Anesthesia & Pain Medicine 2017, 42: 197-203. PMID: 28079734, DOI: 10.1097/aap.0000000000000542.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAnalgesia, EpiduralAnesthesia, EpiduralAnticoagulantsBaltimoreCatheters, IndwellingColonDatabases, FactualDevice RemovalDigestive System Surgical ProceduresDrug Administration ScheduleEarly AmbulationHeparinHumansProgram EvaluationRectumRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVenous ThromboembolismConceptsThoracic epidural analgesiaVTE prophylaxisEpidural removalERAS programVenous thromboembolismTEA patientsHeparin dosesEpidural analgesiaSurgery pathwayPerioperative thoracic epidural analgesiaColorectal surgery patientsDose of UFHOptimal VTE prophylaxisPercent of patientsThoracic epidural anesthesiaEpidural catheter placementSingle academic centerPreoperative dosesThrombohemorrhagic complicationsColorectal surgeryEpidural hematomaNeuraxial analgesiaSurgery patientsSurgical indicationsUnfractionated heparin
2013
Clinical predictors of postoperative hemoglobin drift
Grant M, Whitman G, Savage W, Ness P, Frank S. Clinical predictors of postoperative hemoglobin drift. Transfusion 2013, 54: 1460-1468. PMID: 24236570, DOI: 10.1111/trf.12491.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBlood TransfusionDecision MakingFemaleHemoglobinsHumansMaleMiddle AgedPostoperative PeriodRetrospective StudiesConceptsSurgical proceduresClinical predictorsBlood requirementsClinical variablesPerioperative patient blood managementPositive perioperative fluid balanceIntraoperative intravenous fluidsPerioperative fluid balanceIntraoperative blood lossType of surgeryPatient blood managementCommon surgical procedureMultiple clinical variablesSpinal fusion proceduresPostoperative transfusionRed blood cellsBlood lossIndependent predictorsSurgical patientsIntravenous fluidsBlood managementSpinal fusionFluid balanceHemoglobin measurementHb concentration