2023
Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Mendez-Pino L, Urman R, Varelmann D. Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1734-1743. PMID: 37330329, DOI: 10.1053/j.jvca.2023.05.035.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansLungLung DiseasesPostoperative ComplicationsRespiration DisordersRetrospective StudiesRisk FactorsConceptsPostoperative pulmonary complicationsLung resection surgeryRisk-scoring systemPulmonary complicationsResection surgeryScoring systemLung resectionRisk scoreRisk of PPCsRetrospective cohort study SETTINGLAS VEGASAlternative risk scoresSingle-center cohortCohort study SETTINGAdult patientsExpiratory volumeLung surgeryThoracic surgeryPulmonary riskConcordance indexSurgeryPatientsDiscriminatory powerStudy settingComplications
2022
Early Return to Intended Oncologic Therapy after implementation of an Enhanced Recovery After Surgery pathway for gastric cancer surgery
Garcia-Nebreda M, Zorrilla-Vaca A, Ripollés-Melchor J, Abad-Motos A, Alvaro Cifuentes E, Abad-Gurumeta A, Mena G, Grant M, Paseiro-Crespo G. Early Return to Intended Oncologic Therapy after implementation of an Enhanced Recovery After Surgery pathway for gastric cancer surgery. Langenbeck's Archives Of Surgery 2022, 407: 2293-2300. PMID: 35441358, DOI: 10.1007/s00423-022-02515-7.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaDigestive System Surgical ProceduresEnhanced Recovery After SurgeryHumansLength of StayPostoperative ComplicationsStomach NeoplasmsConceptsGastric cancer surgeryCancer surgeryERAS pathwayAdjuvant therapySurgery pathwayOncologic therapyGastric adenocarcinomaEnhanced recoveryPostoperative oncologic outcomesPre-ERAS periodERAS groupHospital stayOncologic outcomesPrimary outcomeShorter LOSResultsSeventy patientsEarly returnSurgeryIntervention studiesTherapyPatientsMedian differenceAdenocarcinomaOutcomesPathwayAssociation between enrollment in an enhanced recovery program for colorectal cancer surgery and long‐term recurrence and survival
Zorrilla‐Vaca A, Ripolles‐Melchor J, Abad‐Motos A, Mingu I, Moreno‐Jurado N, Martínez‐Durán F, Pérez‐Martínez I, Abad‐Gurumeta A, FuenMayor‐Varela M, Mena G, Grant M. Association between enrollment in an enhanced recovery program for colorectal cancer surgery and long‐term recurrence and survival. Journal Of Surgical Oncology 2022, 125: 1269-1276. PMID: 35234283, DOI: 10.1002/jso.26836.Peer-Reviewed Original ResearchMeSH KeywordsColorectal NeoplasmsDigestive System Surgical ProceduresEnhanced Recovery After SurgeryHumansLength of StayPostoperative ComplicationsConceptsColorectal cancer surgeryCancer surgeryOncologic recurrenceColorectal cancerCancer stageCox hazard regression analysisMedian compliance rateSurgical inflammatory responseAdvanced colorectal cancerEnhanced recovery programmeOverall survival rateHazards regression analysisLong-term recurrenceAdvanced cancer stageERAS groupERAS interventionsERAS programOverall survivalMultivariable analysisSubgroup analysisInflammatory responseSurgery programLower riskEnhanced recoveryIntervention studiesPatient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study
Galarza-Prado A, Zorrilla-Vaca A, Healy R, Ripollés J, Abad-Motos A, Nozal-Mateo B, Del Rio S, Caballero-Lozada A, Stone A, Mena G, Grant M. Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study. Journal Of Gastrointestinal Surgery 2022, 26: 911-916. PMID: 35059982, DOI: 10.1007/s11605-021-05234-4.Peer-Reviewed Original ResearchMeSH KeywordsColorectal SurgeryCoronary Artery DiseaseGuideline AdherenceHumansHypoalbuminemiaLength of StayPostoperative ComplicationsProspective StudiesConceptsCoronary artery diseaseColorectal surgeryPreoperative hypoalbuminemiaPreoperative transfusionPatient characteristicsArtery diseaseHigh adherenceRecovery protocolMultivariable logistic regression analysisEnhanced recovery protocolMulticentric prospective studyLow complication rateLogistic regression analysisClinical characteristicsComplication rateMetastatic diseaseSurgical characteristicsCancer resectionSurgery guidelinesProspective studyAdequate adherenceUnivariate analysisLow adherenceMultivariable modelPatients
2021
Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery
Metkus T, Thibault D, Grant M, Badhwar V, Jacobs J, Lawton J, O'Brien S, Thourani V, Wegermann Z, Zwischenberger B, Higgins R. Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery. Journal Of The American College Of Cardiology 2021, 78: 112-122. PMID: 33957241, PMCID: PMC8876254, DOI: 10.1016/j.jacc.2021.04.064.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, TransesophagealHumansMiddle AgedPostoperative ComplicationsRetrospective StudiesUnited StatesConceptsIntraoperative transesophageal echocardiographyHigh-risk patientsTransesophageal echocardiographyCABG patientsOperative mortalityValve proceduresCoronary artery bypass graft surgeryThoracic Surgeons Adult Cardiac Surgery DatabaseArtery bypass graft surgeryAdult Cardiac Surgery DatabasePost-CABG mortalityBypass graft surgeryCoronary artery bypassRetrospective cohort studyLow operative mortalityPercentage of patientsCardiac Surgery DatabaseClinical decision makingArtery bypassGraft surgeryValve surgeryCohort studyCABG proceduresPrimary outcomeSurgery DatabaseGuidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization
Peden C, Aggarwal G, Aitken R, Anderson I, Foss N, Cooper Z, Dhesi J, French W, Grant M, Hammarqvist F, Hare S, Havens J, Holena D, Hübner M, Kim J, Lees N, Ljungqvist O, Lobo D, Mohseni S, Ordoñez C, Quiney N, Urman R, Wick E, Wu C, Young-Fadok T, Scott M. Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization. World Journal Of Surgery 2021, 45: 1272-1290. PMID: 33677649, PMCID: PMC8026421, DOI: 10.1007/s00268-021-05994-9.Peer-Reviewed Original ResearchMeSH KeywordsElective Surgical ProceduresEnhanced Recovery After SurgeryHumansLaparotomyLength of StayPerioperative CarePostoperative ComplicationsPreoperative CareConceptsEmergency laparotomyERAS approachEmergency general surgical patientsFirst consensus guidelinesSurgery (ERAS) Society RecommendationsEmergency general surgeryGeneral surgical patientsGrading of RecommendationsHigh-risk patientsLength of stayElective surgical proceduresLarge cohort studyBest available evidenceMEDLINE database searchNon-emergency patientsEnglish-language publicationsERAS elementsCohort studyInitial managementSurgery protocolSurgical patientsPerioperative carePhysiological derangementsPreoperative carePostoperative management
2020
Enhanced Recovery Programs for Colorectal Surgery and Postoperative Acute Kidney Injury: Results From a Systematic Review and Meta-Analysis of Observational Studies
Zorrilla-Vaca A, Mena G, Cata J, Healy R, Grant M. Enhanced Recovery Programs for Colorectal Surgery and Postoperative Acute Kidney Injury: Results From a Systematic Review and Meta-Analysis of Observational Studies. The American Surgeon 2020, 87: 1444-1451. PMID: 33375852, DOI: 10.1177/0003134820954846.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryColorectal SurgeryEnhanced Recovery After SurgeryHumansObservational Studies as TopicPostoperative ComplicationsConceptsPostoperative acute kidney injuryAcute kidney injuryObservational studyKidney injuryColorectal surgeryConventional careSystematic reviewHigh-risk patient populationConventional perioperative carePerioperative health careRestrictive fluid administrationEnhanced recovery programmeRisk patient populationEvidence-based measuresHemodynamic goalsPostoperative recoveryERP patientsPerioperative careFluid administrationNephrotoxic agentsPatient populationPooled resultsGreater oddsRecovery programMeta-AnalysisGoal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Abad-Motos A, Aldecoa C, Lorente J, Ramirez-Rodriguez J, Grant M. Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study. The American Surgeon 2020, 87: 1189-1195. PMID: 33342254, DOI: 10.1177/0003134820973365.Peer-Reviewed Original ResearchConceptsGoal-directed fluid therapyEnhanced recovery programmeAcute kidney injurySurgical site infectionColorectal surgeryPostoperative outcomesFluid therapyPostoperative acute kidney injuryPropensity score-matched analysisComparable baseline demographicsMajor postoperative outcomesAdequate tissue perfusionRates of morbidityHospital stayKidney injuryBaseline demographicsCohort studyConventional careERAS programAnastomotic dehiscenceMajor surgerySite infectionPulmonary edemaMulticenter studyTherapy patientsRisk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Lorente J, Ramirez-Rodriguez J, Grant M. Risk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery. Surgery Today 2020, 51: 537-544. PMID: 32785846, DOI: 10.1007/s00595-020-02107-2.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedAged, 80 and overColonCreatinineDigestive System Surgical ProceduresEnhanced Recovery After SurgeryFemaleHumansMaleMalnutritionMiddle AgedMulticenter Studies as TopicNutritional StatusPostoperative ComplicationsProspective StudiesRectumRisk FactorsROC CurveSerum AlbuminConceptsPostoperative acute kidney injuryAcute kidney injuryColorectal surgeryRisk factorsKidney injuryLow preoperative albumin levelRecovery pathwaysPerioperative patient outcomesPreoperative albumin levelEnhanced recovery pathwayIndependent risk factorProspective cohort studyPoor clinical outcomeDirect healthcare costsOpen surgical approachMalnourished patientsCohort studyAlbumin levelsASA IIILarge multicenterPreoperative interventionClinical outcomesMultivariable analysisOverall incidenceModifiable factors
2019
Opioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery
Owodunni O, Zaman M, Ighani M, Grant M, Bettick D, Sateri S, Magnuson T, Gearhart S. Opioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery. Surgery 2019, 166: 1055-1060. PMID: 31526584, DOI: 10.1016/j.surg.2019.08.001.Peer-Reviewed Original ResearchConceptsEnhanced recovery pathwayMajor abdominal surgeryOpioid-tolerant patientsOpioid toleranceAbdominal surgeryLength of stayTolerant patientsRecovery pathwaysPostoperative outcomesMajor complicationsPathway complianceChallenging patient cohortNon-tolerant patientsPoor postoperative outcomesOperative Severity ScoreEnUmeration of MortalityRisk-adjusted analysisPrescribed opioid medicationsOutcomes of interestEvidence-based interventionsColorectal PhysiologicalOral morphineOpioid medicationsEmergency surgeryReadmission ratesEvidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery
Grant M, Gibbons M, Ko C, Wick E, Cannesson M, Scott M, McEvoy M, King A, Wu C. Evidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30113392, DOI: 10.1213/ane.0000000000003696.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaBariatric SurgeryEvidence-Based MedicineHealth Services ResearchHumansOutcome and Process Assessment, Health CarePatient SafetyPostoperative ComplicationsPractice Guidelines as TopicQuality ImprovementQuality Indicators, Health CareRecovery of FunctionRisk AssessmentRisk FactorsTreatment OutcomeConceptsBariatric surgeryQuality Safety ProgramSurgical careHealthcare ResearchJohns Hopkins Medicine Armstrong InstituteEvidence reviewAvailable evidenceSafety programHospital staySurgery protocolPostoperative phaseSociety guidelinesAnesthetic interventionsAnesthetic componentsArmstrong InstituteAmerican CollegeSurgeryEnhanced recoverySuperior outcomesLiterature searchPatient safetyFacilitate recoveryCareInterventionOutcomesDischarge Hemoglobin Level and 30-Day Readmission Rates After Coronary Artery Bypass Surgery
Cho B, DeMario V, Grant M, Hensley N, Brown C, Hebbar S, Mandal K, Whitman G, Frank S. Discharge Hemoglobin Level and 30-Day Readmission Rates After Coronary Artery Bypass Surgery. Anesthesia & Analgesia 2019, 128: 342-348. PMID: 30059402, PMCID: PMC6533067, DOI: 10.1213/ane.0000000000003671.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassFemaleHemoglobinsHumansMaleMiddle AgedPatient DischargePatient ReadmissionPostoperative ComplicationsRetrospective StudiesRisk FactorsTime FactorsConceptsDischarge Hb levelsDischarge hemoglobin levelsReadmission ratesHb levelsPatient characteristicsHemoglobin levelsMultivariable analysisBlood utilizationCoronary artery bypass surgeryCertain patient comorbiditiesRestrictive transfusion strategyCharlson Comorbidity IndexCoronary artery bypassArtery bypass surgeryLarge randomized trialsRisk-adjusted oddsSimilar patient characteristicsLow Hb levelsCABG patientsDischarge HbPreoperative comorbiditiesArtery bypassComorbidity indexBypass surgeryPatient comorbidities
2018
Early ambulation after colorectal oncologic resection with perineal reconstruction is safe and effective
Calotta N, Coon D, Bos T, Ostrander B, Scott A, Grant M, Efron J, Sacks J. Early ambulation after colorectal oncologic resection with perineal reconstruction is safe and effective. The American Journal Of Surgery 2018, 218: 125-130. PMID: 30471809, DOI: 10.1016/j.amjsurg.2018.10.005.Peer-Reviewed Original ResearchConceptsEarly ambulationPerineal reconstructionOncologic resectionPost-operative day oneEarly ambulation protocolRetrospective cohort studyMinor complication rateStandard of careOncological surgery patientsAmbulation capacityWound complicationsCohort studySurgery patientsComplication rateSurgical outcomesReconstructive outcomesAmbulationMore ambulatoryBedrestDay oneReoperationReadmissionResectionSignificant differencesPatientsIntraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials
Zorrilla-Vaca A, Healy R, Grant M, Joshi B, Rivera-Lara L, Brown C, Mirski M. Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials. Journal Canadien D'anesthésie 2018, 65: 529-542. PMID: 29427259, DOI: 10.1007/s12630-018-1065-7.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionIntensive care unitIntraoperative cerebral oximetryCerebral oximetryPostoperative deliriumIncidence of POCDProspective clinical trialsOverall hospital LOSPredictors of outcomeGoogle Scholar databasesHospital LOSPurposeAlthough evidenceHospital lengthPerioperative outcomesPostoperative outcomesSecondary outcomesPrimary outcomeCare unitClinical outcomesIntraoperative managementLarge RCTsCochrane LibraryClinical trialsCognitive dysfunctionObservational study
2017
Optimizing an Enhanced Recovery Pathway Program: Development of a Postimplementation Audit Strategy
Grant M, Galante D, Hobson D, Lavezza A, Friedman M, Wu C, Wick E. Optimizing an Enhanced Recovery Pathway Program: Development of a Postimplementation Audit Strategy. The Joint Commission Journal On Quality And Patient Safety 2017, 43: 524-533. PMID: 28942777, DOI: 10.1016/j.jcjq.2017.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersClinical ProtocolsDigestive System Surgical ProceduresElectronic Health RecordsFemaleGroup ProcessesHumansLength of StayMaleMiddle AgedOrganizational CulturePatient Care BundlesPatient Care TeamPerioperative CarePostoperative ComplicationsQuality Indicators, Health CareRetrospective StudiesSafety ManagementConceptsLength of stayOverall LOSAverage LOSProcess measuresThree-month followProcess measure complianceAcademic medical centerSystem-level interventionsSignificant reductionElectronic health recordsColorectal surgeryConsecutive patientsPathway implementationEarly mobilityMeasure complianceMedical CenterPreventable harmOne-year periodPatientsRecovery pathwaysHealth recordsSystem-level changesSurgeryComplianceSame procedureRelation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies
Zorrilla-Vaca A, Healy R, Wu C, Grant M. Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies. Journal Canadien D'anesthésie 2017, 64: 597-607. PMID: 28361391, DOI: 10.1007/s12630-017-0872-6.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaAnestheticsConsciousness MonitorsHumansObservational Studies as TopicPostoperative ComplicationsPostoperative PeriodConceptsDepth of anesthesiaLow bispectral indexObservational studyBispectral indexSubgroup analysisSignificant associationResultsEight observational studiesLong-term mortalityPooled effect sizeMain electronic databasesBispectral index measurementsRandom-effects modelPostoperative mortalityHazard ratioIntroductionThe associationRandomized trialsInclusion criteriaAnesthesiaElectronic databasesNarrative reviewPotential associationAnesthetic depthMethodsThe literatureMortalityAnesthesia depthImpact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections
Grant M, Yang D, Wu C, Makary M, Wick E. Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections. Annals Of Surgery 2017, 265: 68-79. PMID: 28009729, DOI: 10.1097/sla.0000000000001703.Peer-Reviewed Original ResearchMeSH KeywordsCross InfectionHumansLength of StayPerioperative CarePostoperative ComplicationsTreatment OutcomeConceptsHealthcare-associated infectionsSurgical site infectionUrinary tract infectionLung infectionFTS protocolFast-track surgery pathwaysFast-track surgery protocolMajor healthcare-associated infectionPostoperative lung infectionLength of staySignificant reductionPostoperative incidenceHospital lengthColorectal surgerySurgery protocolTract infectionsPerioperative carePrimary outcomeSite infectionRandomized trialsSurgery pathwayPelvic surgerySubgroup analysisSurgical careHigh risk
2016
A Meta-analysis of Intraoperative Ventilation Strategies to Prevent Pulmonary Complications
Yang D, Grant M, Stone A, Wu C, Wick E. A Meta-analysis of Intraoperative Ventilation Strategies to Prevent Pulmonary Complications. Annals Of Surgery 2016, 263: 881-887. PMID: 26720429, DOI: 10.1097/sla.0000000000001443.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureAcute lung injuryPostoperative lung infectionLung infectionLung ventilationLTV ventilationHospital stayHealthy patientsLow tidal volume mechanical ventilationPostoperative acute lung injuryIntermittent recruitment maneuverIntraoperative ventilation strategiesProtective lung ventilationLength of hospitalProtective ventilation strategyEnd-expiratory pressureVolume mechanical ventilationVentilation strategiesAnalysis of trialsPostoperative incidencePulmonary complicationsPulmonary outcomesProtective ventilationLung injuryRecruitment maneuversPatient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection
Page A, Gani F, Crowley K, Lee K, Grant M, Zavadsky T, Hobson D, Wu C, Wick E, Pawlik T. Patient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection. British Journal Of Surgery 2016, 103: 564-571. PMID: 26859713, DOI: 10.1002/bjs.10087.Peer-Reviewed Original ResearchConceptsPost-ERAS groupPerioperative care pathwaysERAS pathwayOpen liver surgeryHospital stayPerioperative outcomesPostoperative complicationsOpioid useLiver surgeryCare pathwayProviders' perceptionsMean pain scoreOpen liver resectionShorter hospital stayImproved perioperative outcomesGroup of patientsCent of providersPerioperative pathwayPain scoresERAS programLiver resectionSurgery pathwayDisease characteristicsHepatic surgeryHospital costsImplementation Costs of an Enhanced Recovery After Surgery Program in the United States: A Financial Model and Sensitivity Analysis Based on Experiences at a Quaternary Academic Medical Center
Stone A, Grant M, Roda C, Hobson D, Pawlik T, Wu C, Wick E. Implementation Costs of an Enhanced Recovery After Surgery Program in the United States: A Financial Model and Sensitivity Analysis Based on Experiences at a Quaternary Academic Medical Center. Journal Of The American College Of Surgeons 2016, 222: 219-225. PMID: 26774492, DOI: 10.1016/j.jamcollsurg.2015.11.021.Peer-Reviewed Original Research