1998
Morphology of Single Geniculocortical Afferents and Functional Recovery of the Visual Cortex after Reverse Monocular Deprivation in the Kitten
Antonini A, Gillespie DC, Crair MC, Stryker MP. Morphology of Single Geniculocortical Afferents and Functional Recovery of the Visual Cortex after Reverse Monocular Deprivation in the Kitten. Journal Of Neuroscience 1998, 18: 9896-9909. PMID: 9822746, PMCID: PMC2452997, DOI: 10.1523/jneurosci.18-23-09896.1998.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusMonocular deprivationFunctional recoveryGeniculocortical afferentsArea 17Visual cortical responsesInitial deprivationSimilar proportional changesTotal arbor lengthPossible anatomical basisLayer IVArbor lengthGeniculate nucleusCortical responsesAfferent arborsSecond deprivationLamina ANormal animalsVisual cortexPlastic changesAnatomical basisInitial weeksArborsEyesAfferents
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanism