2024
Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2020
Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics
Cardin JA, Crair MC, Higley MJ. Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics. Neuron 2020, 108: 33-43. PMID: 33058764, PMCID: PMC7577373, DOI: 10.1016/j.neuron.2020.09.031.Peer-Reviewed Original Research
2016
Reconnecting Eye to Brain
Crair MC, Mason CA. Reconnecting Eye to Brain. Journal Of Neuroscience 2016, 36: 10707-10722. PMID: 27798125, PMCID: PMC5083002, DOI: 10.1523/jneurosci.1711-16.2016.Peer-Reviewed Original ResearchConceptsAudacious Goals InitiativeNational Eye InstituteRetinal ganglion cellsSystem regenerationEye InstituteGanglion cellsVisual functionTraumatic injuryVisual system functionNeural regenerationTarget engagementDisease-induced degenerationRegenerative capacityVisual systemAxon guidanceSystem functionSignificant barriersCurrent understandingSatellite meetingInjuryAxonsDegenerationNeuronsBrain
2015
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa
Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nature Communications 2015, 6: 8005. PMID: 26272629, PMCID: PMC4538705, DOI: 10.1038/ncomms9005.Peer-Reviewed Original ResearchConceptsRetinitis pigmentosaVisual functionRd1 miceCone photoreceptor deathMultiple cell death pathwaysRd1 mutationPhotoreceptor protectionPhotoreceptor deathEffective treatmentAnimal modelsPhotoreceptor degenerationRod deathCone photoreceptorsRod survivalInvaluable animal modelHDAC4 proteinMicePigmentosaCell death pathwaysRod photoreceptorsProtein therapyTherapyHDAC4DeathSurvival
2013
Role of emergent neural activity in visual map development
Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Current Opinion In Neurobiology 2013, 24: 166-175. PMID: 24492092, PMCID: PMC3957181, DOI: 10.1016/j.conb.2013.11.011.Peer-Reviewed Original ResearchConceptsRetinal wavesNeural activitySpontaneous activityNormal visual functionOnset of visionVisual functionGestational periodCalcium influxFunctional visionLong gestational periodNervous systemVisual circuitsNeurotransmitter releaseNerve cellsAssociative circuitsCircuit connectivitySensory-motor systemEye openingFunctional developmentVisuomotor learningSpecific spatiotemporal patternsSpontaneous patternsExcitable cellsOnsetFuture studies
2008
Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse
Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC. Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse. Journal Of Neuroscience 2008, 28: 7057-7067. PMID: 18614674, PMCID: PMC2667968, DOI: 10.1523/jneurosci.3598-06.2008.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusSuperior colliculusOptic tractRetinotopic map formationRetinal ganglion cell axonsBone morphogenetic proteinCentral brain targetsRetinocollicular map formationGanglion cell axonsMap formationWild-type miceStrains of miceAxon behaviorEarly eye formationAxon orderRetinal cell fateOptic chiasmRGC axonsBrain targetsGeniculate nucleusCell axonsPotential downstream effectorsAxon sortingMorphogenetic proteinsMice
2005
Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components
Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ. Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components. Neuron 2005, 46: 219-232. PMID: 15848801, DOI: 10.1016/j.neuron.2005.02.029.Peer-Reviewed Original ResearchConceptsExocyst componentsComplex of proteinsCell polaritySec15Specific cell adhesionSpecific proteinsMutant neuronsSubcellular distributionCell adhesionCell lethalityExocystNeuronal targetingSec5Neurite outgrowthSynaptic specificityCell viabilityProteinSeparable functionsSec6Sec8SubcomplexMislocalizationYeastGenesComponents persist
2002
Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.
Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 2002, 129: 467-77. PMID: 11807038, DOI: 10.1242/dev.129.2.467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCell DifferentiationCulture TechniquesDNA-Binding ProteinsFemaleGene TargetingHumansMaleMiceMice, KnockoutMicroscopy, FluorescenceNeuritesRetinaRetinal Ganglion CellsTranscription Factor Brn-3Transcription Factor Brn-3ATranscription Factor Brn-3BTranscription Factor Brn-3CTranscription FactorsConceptsDouble knockout miceGanglion cell differentiationRetinal ganglion cell differentiationRetinal ganglion cellsOptic chiasmKnockout miceGanglion cellsMost retinal ganglion cellsRetinal ganglion cell axonsRetinal ganglion cell developmentGanglion cell axonsAxon outgrowthGanglion cell developmentCell differentiationDorsal rootsProjection neuronsTrigeminal ganglionCell axonsRetinal explantsPOU domain transcription factorBrn3bBrn3cMiceChiasmInner ear