2018
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
Yao K, Qiu S, Wang YV, Park SJH, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature 2018, 560: 484-488. PMID: 30111842, PMCID: PMC6107416, DOI: 10.1038/s41586-018-0425-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninBlindnessCell CycleCell ProliferationCellular ReprogrammingDisease Models, AnimalFemaleGTP-Binding Protein alpha SubunitsHeterotrimeric GTP-Binding ProteinsMaleMiceNeurogenesisNeurogliaRegenerative MedicineRetinal Rod Photoreceptor CellsStem CellsTranscription FactorsTransducinVisual CortexVisual PathwaysConceptsMüller gliaGene transferMG proliferationRod photoreceptorsMammalian retinaCell fate specificationPopulations of stemSubsequent gene transferFate specificationRetinal stem cellsTranscription factorsRetinal neuronsCell cycleDouble mutant miceRegenerative machineryDe novo genesisΒ-cateninStem cellsProgenitor cellsRestoration of visionPrimary visual cortexMutant miceAbsence of injuryPhotoreceptorsRetinal injury
2005
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development
Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development 2005, 132: 913-923. PMID: 15673568, DOI: 10.1242/dev.01673.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCell ProliferationChromosome MappingFibroblast Growth FactorsGene Expression Regulation, DevelopmentalImmunohistochemistryIn Situ HybridizationMiceMice, TransgenicModels, BiologicalModels, GeneticMutationNeuronsOptic NerveProtein Serine-Threonine KinasesReceptors, Growth FactorRetinaSignal TransductionTransgenesConceptsDistinct developmental programsDevelopmental programRetinal developmentBMP receptor activityReceptor geneCell-autonomous requirementCre-loxP strategySevere eye defectsDirect genetic evidenceEmbryonic tissue interactionsMouse retinal developmentEye abnormalitiesMutant backgroundDorsoventral patterningMouse retinaReceptor activityDouble mutantReceptor functionEmbryonic retinaBMP familyRedundant rolesRetinal neurogenesisFunctional copyEmbryonic developmentGenetic evidence