2021
Retinal waves prime visual motion detection by simulating future optic flow
Ge X, Zhang K, Gribizis A, Hamodi AS, Sabino AM, Crair MC. Retinal waves prime visual motion detection by simulating future optic flow. Science 2021, 373 PMID: 34437090, PMCID: PMC8841103, DOI: 10.1126/science.abd0830.Peer-Reviewed Original ResearchConceptsEye-specific segregationSpontaneous retinal wavesVisual response propertiesSpontaneous retinal activityDirection-selective responsesSuperior colliculus neuronsOptic flow patternsRetinal wavesRetinal activityColliculus neuronsRetinal circuitsSpontaneous activityChronic disruptionVisual motion detectionEye openingTransient windowResponse propertiesOptic flowSensory experienceNeuronsPreservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2017
Architecture, Function, and Assembly of the Mouse Visual System
Seabrook TA, Burbridge TJ, Crair MC, Huberman AD. Architecture, Function, and Assembly of the Mouse Visual System. Annual Review Of Neuroscience 2017, 40: 499-538. PMID: 28772103, DOI: 10.1146/annurev-neuro-071714-033842.Peer-Reviewed Original ResearchConceptsSpecific cell typesMammalian central nervous systemGenetic perturbationsModel speciesCell typesCausal testingSpeciesVivo labelingBroad scaleVisual system structuresManipulation of neuronsSensory systemsCentral nervous systemVisual circuitryPowerful toolNervous systemLarge cadreHumansMouse visual systemAdditional experimentationPathwayFunctionConvenient sizeAssemblyVisual system
2015
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa
Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nature Communications 2015, 6: 8005. PMID: 26272629, PMCID: PMC4538705, DOI: 10.1038/ncomms9005.Peer-Reviewed Original ResearchConceptsRetinitis pigmentosaVisual functionRd1 miceCone photoreceptor deathMultiple cell death pathwaysRd1 mutationPhotoreceptor protectionPhotoreceptor deathEffective treatmentAnimal modelsPhotoreceptor degenerationRod deathCone photoreceptorsRod survivalInvaluable animal modelHDAC4 proteinMicePigmentosaCell death pathwaysRod photoreceptorsProtein therapyTherapyHDAC4DeathSurvival
1998
The Role of Visual Experience in the Development of Columns in Cat Visual Cortex
Crair M, Gillespie D, Stryker M. The Role of Visual Experience in the Development of Columns in Cat Visual Cortex. Science 1998, 279: 566-570. PMID: 9438851, PMCID: PMC2453000, DOI: 10.1126/science.279.5350.566.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCatsMicroelectrodesPhotic StimulationVision, MonocularVision, OcularVisual CortexVisual PathwaysConceptsCortical mapsVisual cortexCat visual cortexPrimary visual cortexWeeks of ageTime course parallelContralateral eyeCerebral cortexCortical plasticityCortical neuronsOcular dominanceVisual deprivationPattern visionCortexWeeksEyesVisual experienceCritical periodCourse parallelCatsNeuronsResponse