2013
Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEvoked Potentials, SomatosensoryGlutamic AcidMiceNeural PathwaysNeuronsSomatosensory CortexSynaptic TransmissionThalamusConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factors
2011
How do barrels form in somatosensory cortex?
Li H, Crair MC. How do barrels form in somatosensory cortex? Annals Of The New York Academy Of Sciences 2011, 1225: 119-129. PMID: 21534999, PMCID: PMC4700879, DOI: 10.1111/j.1749-6632.2011.06024.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningHair FollicleMiceModels, BiologicalOrgan SpecificitySomatosensory CortexVibrissae
2007
Development of Cortical Maps: Perspectives From the Barrel Cortex
Inan M, Crair MC. Development of Cortical Maps: Perspectives From the Barrel Cortex. The Neuroscientist 2007, 13: 49-61. PMID: 17229975, DOI: 10.1177/1073858406296257.Peer-Reviewed Original ResearchConceptsBarrel mapThalamic axonsBarrel cortexBarrel map formationActivity-dependent cuesMolecular cuesSensory afferentsMotor cortexPrimary somatosensoryThalamocortical axonsSomatosensory cortexCortical neuronsSynapse maturationNeuronal activityFunctional maturationVentricular cellsCortical mapsCortexAxonsNeocortical developmentWiring principlesCortical patterningMammalian neocortexNeocortexNeurons
2006
Role of Efficient Neurotransmitter Release in Barrel Map Development
Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC. Role of Efficient Neurotransmitter Release in Barrel Map Development. Journal Of Neuroscience 2006, 26: 2692-2703. PMID: 16525048, PMCID: PMC6675166, DOI: 10.1523/jneurosci.3956-05.2006.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBlotting, WesternBrain MappingCalciumDizocilpine MaleateDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGTP-Binding ProteinsIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsModels, NeurologicalNeural PathwaysNeuronal PlasticityNeurotransmitter AgentsN-MethylaspartatePatch-Clamp TechniquesSomatosensory CortexSynapsinsThalamusTime FactorsConceptsThalamocortical afferentsEfficient neurotransmitter releaseNeurotransmitter releaseBarrelless miceActivity-dependent processesNeuronal circuit formationAdenylyl cyclase IBarrel mapSynaptic transmissionPresynaptic terminalsPresynaptic functionCircuit formationCortical mapsMutant miceMiceNeuronal modulesRelease efficacyEfficient synaptic transmissionActive zone proteinsZone proteinEfficacyMap developmentRIM proteinsAC1 functionRelease
2001
Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition
Lu H, Gonzalez E, Crair M. Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition. Neuron 2001, 32: 619-634. PMID: 11719203, DOI: 10.1016/s0896-6273(01)00501-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCritical Period, PsychologicalExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalLong-Term PotentiationMiceMice, Inbred C57BLMice, KnockoutNeuronal PlasticityPiperidinesQuinoxalinesReceptors, AMPAReceptors, N-Methyl-D-AspartateSomatosensory CortexSynapsesThalamusConceptsNMDA receptor subunit compositionReceptor subunit compositionSubunit compositionMouse somatosensory barrel cortexCritical periodNR2A knockout miceCritical period plasticitySomatosensory barrel cortexNMDAR subunit compositionCurrent kineticsAfferent innervationBarrel cortexNR2B subunitKnockout miceSynaptic plasticityNR2A subunitPlasticity windowSubunits
1999
Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording
Higashi S, Crair MC, Kurotani T, Inokawa H, Toyama K. Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording. Neuroscience 1999, 91: 439-452. PMID: 10366001, DOI: 10.1016/s0306-4522(98)00666-6.Peer-Reviewed Original ResearchConceptsInfraorbital nerve cutNerve cutNormal ratsLayer IVSomatosensory cortexDextran amine labelingThalamocortical slice preparationPostnatal day 7Cytochrome oxidase stainingThalamocortical transmissionThalamocortical connectionsDextran amineThalamocortical axonsThalamic stimulationBarrel cortexFunctional synapsesSlice preparationAxon terminalsVoltage-sensitive dyeTerminal arborsAltered spatial patternDay 7P5-P6RatsBarrel formation
1997
Silent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation
1996
[The development of rat somatosensory (barrel) cortex visualized by optical recording].
Kurotani T, Crair MC, Higashi S, Toyama K, Molnar Z. [The development of rat somatosensory (barrel) cortex visualized by optical recording]. Protein (Tokyo) 1996, 41: 758-65. PMID: 8787046.Peer-Reviewed Original Research
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanism