2024
Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity
Matsumoto N, Barson D, Liang L, Crair M. Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity. Science 2024, 385: eadh7814. PMID: 39146415, DOI: 10.1126/science.adh7814.Peer-Reviewed Original ResearchConceptsSpontaneous activitySpontaneous retinal wavesAxonal connectionsPatterns of correlated activityNeonatal miceEvidence in vivoRetinal wavesPostsynaptic neuronsNeuronal activityIn vivoAxonal arborsAxonal processesAxonsRetinocollicular axonsNeural connectionsIndividual axonsMorphological changesSubcellular precisionEndogenous pattern
2019
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagatesVisual Cortex Gains Independence from Peripheral Drive before Eye Opening
Gribizis A, Ge X, Daigle TL, Ackman JB, Zeng H, Lee D, Crair MC. Visual Cortex Gains Independence from Peripheral Drive before Eye Opening. Neuron 2019, 104: 711-723.e3. PMID: 31561919, PMCID: PMC6872942, DOI: 10.1016/j.neuron.2019.08.015.Peer-Reviewed Original ResearchConceptsSuperior colliculusEarly functional developmentSpontaneous neuronal activitySecond postnatal weekPrimary visual cortexPeripheral driveCortex maturesRetinal activityPostnatal weekNeuronal activityDirect projectionsVisual cortexMammalian brainSensory peripheryVisual-spatial perceptionEye openingFunctional developmentPeripheral activityColliculusWeeksDistinct pathwaysPathwayRelative functionV1Thalamus
2017
Activity-dependent development of visual receptive fields
Thompson A, Gribizis A, Chen C, Crair MC. Activity-dependent development of visual receptive fields. Current Opinion In Neurobiology 2017, 42: 136-143. PMID: 28088066, PMCID: PMC5375035, DOI: 10.1016/j.conb.2016.12.007.Peer-Reviewed Original Research
2013
Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factors
2012
Retinal waves coordinate patterned activity throughout the developing visual system
Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system. Nature 2012, 490: 219-225. PMID: 23060192, PMCID: PMC3962269, DOI: 10.1038/nature11529.Peer-Reviewed Original ResearchConceptsActivity-dependent developmentSpontaneous retinal activityRetinal wavesRetinal activityEntire visual systemPatterned activitySecondary visual areasPrimary visual cortexOnset of visionCholinergic neurotransmissionNeonatal miceNeuronal activitySpontaneous activityNervous systemVisual cortexVertebrate nervous systemVisual areasVisual systemVisual fieldGenetic factorsEye openingFunctional developmentOnsetActivityNeurotransmission
2011
An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development
Xu HP, Furman M, Mineur YS, Chen H, King SL, Zenisek D, Zhou ZJ, Butts DA, Tian N, Picciotto MR, Crair MC. An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development. Neuron 2011, 70: 1115-1127. PMID: 21689598, PMCID: PMC3119851, DOI: 10.1016/j.neuron.2011.04.028.Peer-Reviewed Original ResearchConceptsSpontaneous retinal activityRetinal activityRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesActivity-dependent refinementRetinal ganglion cellsMouse visual systemComplex neural circuitsEye of originRetinal wavesGanglion cellsRetinotopic refinementNeuronal activitySpontaneous activityMammalian visual systemAcetylcholine receptorsNeuronal connectivityMammalian brainNeural circuitsOverall activity levelsActivity levelsBrainVisual system
2007
Development of Cortical Maps: Perspectives From the Barrel Cortex
Inan M, Crair MC. Development of Cortical Maps: Perspectives From the Barrel Cortex. The Neuroscientist 2007, 13: 49-61. PMID: 17229975, DOI: 10.1177/1073858406296257.Peer-Reviewed Original ResearchConceptsBarrel mapThalamic axonsBarrel cortexBarrel map formationActivity-dependent cuesMolecular cuesSensory afferentsMotor cortexPrimary somatosensoryThalamocortical axonsSomatosensory cortexCortical neuronsSynapse maturationNeuronal activityFunctional maturationVentricular cellsCortical mapsCortexAxonsNeocortical developmentWiring principlesCortical patterningMammalian neocortexNeocortexNeurons
1999
Neuronal activity during development: permissive or instructive?
Crair M. Neuronal activity during development: permissive or instructive? Current Opinion In Neurobiology 1999, 9: 88-93. PMID: 10072369, DOI: 10.1016/s0959-4388(99)80011-7.Peer-Reviewed Original Research