2009
Long-Term Potentiation and Long-Term Depression in Experience-Dependent Plasticity
Crair M, Shah R. Long-Term Potentiation and Long-Term Depression in Experience-Dependent Plasticity. 2009, 561-570. DOI: 10.1016/b978-008045046-9.01213-4.Peer-Reviewed Original ResearchLong-term depressionExperience-dependent plasticityLong-term potentiationActivity-dependent developmentHebbian synaptic plasticitySynaptic mechanismsMammalian sensory systemsSomatosensory systemSynaptic plasticityTerm potentiationSynaptic homeostasisTiming-dependent plasticityMechanistic linkPotentiationDepressionSensory systemsPlasticityBrain
2006
Barrel Map Development Relies on Protein Kinase A Regulatory Subunit IIβ-Mediated cAMP Signaling
Inan M, Lu HC, Albright MJ, She WC, Crair MC. Barrel Map Development Relies on Protein Kinase A Regulatory Subunit IIβ-Mediated cAMP Signaling. Journal Of Neuroscience 2006, 26: 4338-4349. PMID: 16624954, PMCID: PMC6674004, DOI: 10.1523/jneurosci.3745-05.2006.Peer-Reviewed Original ResearchConceptsBarrel map formationLayer IV neuronsActivity-dependent developmentAMPA receptor functionCAMP/PKA-dependent pathwayLong-term potentiationThalamocortical synapsesThalamocortical afferentsTC synapsesThalamocortical synapseBarrel cortexPKA targetsBarrel patternCortical developmentPKA-dependent pathwayBrain circuitryPostsynaptic processesSynapse formationReceptor functionCAMP-dependent protein kinaseHebbian mechanismsDevelopmental increaseMiceSynapsesActivity-dependent models
2003
Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development
Lu HC, She WC, Plas DT, Neumann PE, Janz R, Crair MC. Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development. Nature Neuroscience 2003, 6: 939-947. PMID: 12897788, DOI: 10.1038/nn1106.Peer-Reviewed Original ResearchConceptsLong-term depressionLong-term potentiationAMPA receptor traffickingThalamocortical synapsesBarrelless miceBarrel map formationSynaptic AMPAR traffickingAMPAR subunit GluR1Activity-dependent mechanismsReceptor traffickingAC1 activityFunctional AMPARsSurface GluR1Thalamocortical afferentsMap formationAdenylyl cyclase IBarrel mapSubunit GluR1Cortical map formationAMPAR traffickingProtein kinase A (PKA) activitySynapsesAdenylyl cyclaseMiceImmature state
1997
Silent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanism