2021
Retinal waves prime visual motion detection by simulating future optic flow
Ge X, Zhang K, Gribizis A, Hamodi AS, Sabino AM, Crair MC. Retinal waves prime visual motion detection by simulating future optic flow. Science 2021, 373 PMID: 34437090, PMCID: PMC8841103, DOI: 10.1126/science.abd0830.Peer-Reviewed Original ResearchConceptsEye-specific segregationSpontaneous retinal wavesVisual response propertiesSpontaneous retinal activityDirection-selective responsesSuperior colliculus neuronsOptic flow patternsRetinal wavesRetinal activityColliculus neuronsRetinal circuitsSpontaneous activityChronic disruptionVisual motion detectionEye openingTransient windowResponse propertiesOptic flowSensory experienceNeurons
2019
Visual Cortex Gains Independence from Peripheral Drive before Eye Opening
Gribizis A, Ge X, Daigle TL, Ackman JB, Zeng H, Lee D, Crair MC. Visual Cortex Gains Independence from Peripheral Drive before Eye Opening. Neuron 2019, 104: 711-723.e3. PMID: 31561919, PMCID: PMC6872942, DOI: 10.1016/j.neuron.2019.08.015.Peer-Reviewed Original ResearchConceptsSuperior colliculusEarly functional developmentSpontaneous neuronal activitySecond postnatal weekPrimary visual cortexPeripheral driveCortex maturesRetinal activityPostnatal weekNeuronal activityDirect projectionsVisual cortexMammalian brainSensory peripheryVisual-spatial perceptionEye openingFunctional developmentPeripheral activityColliculusWeeksDistinct pathwaysPathwayRelative functionV1Thalamus
2013
Role of emergent neural activity in visual map development
Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Current Opinion In Neurobiology 2013, 24: 166-175. PMID: 24492092, PMCID: PMC3957181, DOI: 10.1016/j.conb.2013.11.011.Peer-Reviewed Original ResearchConceptsRetinal wavesNeural activitySpontaneous activityNormal visual functionOnset of visionVisual functionGestational periodCalcium influxFunctional visionLong gestational periodNervous systemVisual circuitsNeurotransmitter releaseNerve cellsAssociative circuitsCircuit connectivitySensory-motor systemEye openingFunctional developmentVisuomotor learningSpecific spatiotemporal patternsSpontaneous patternsExcitable cellsOnsetFuture studiesCompetition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus
Furman M, Xu HP, Crair MC. Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus. Journal Of Neurophysiology 2013, 110: 1441-1454. PMID: 23741047, PMCID: PMC3763158, DOI: 10.1152/jn.01066.2012.Peer-Reviewed Original ResearchConceptsSuperior colliculusRetinal wavesRetinal inputBrain slice preparationActivity-dependent competitionWT miceRetinofugal axonsSlice preparationSC neuronsTransgenic miceBrain regionsSynaptic strengthSynaptic developmentSynapse developmentMiceNeuronsEye openingFunctional developmentSynapsesColliculusMolecular mechanismsSpecific roleInstructive roleMorphological developmentAxons
2012
Retinal waves coordinate patterned activity throughout the developing visual system
Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system. Nature 2012, 490: 219-225. PMID: 23060192, PMCID: PMC3962269, DOI: 10.1038/nature11529.Peer-Reviewed Original ResearchConceptsActivity-dependent developmentSpontaneous retinal activityRetinal wavesRetinal activityEntire visual systemPatterned activitySecondary visual areasPrimary visual cortexOnset of visionCholinergic neurotransmissionNeonatal miceNeuronal activitySpontaneous activityNervous systemVisual cortexVertebrate nervous systemVisual areasVisual systemVisual fieldGenetic factorsEye openingFunctional developmentOnsetActivityNeurotransmissionSynapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening
Furman M, Crair MC. Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening. Journal Of Neurophysiology 2012, 107: 3200-3216. PMID: 22402661, PMCID: PMC3774562, DOI: 10.1152/jn.00943.2011.Peer-Reviewed Original ResearchConceptsSuperior colliculusLateral superior colliculusMedial superior colliculusEye openingP6-7Synaptic strengthBinocular interactionEye-specific segregationPatch-clamp recordingsRetinocollicular synapsesIpsilateral eyeNeonatal miceSlice preparationSynaptic basisMonocular enucleationDendritic arborsSynapse maturationTarget neuronsRetinal axonsDendritic branchingRetinocollicular mapSynaptic connectivityPostsynaptic partnersBinocular competitionSynapse development