2016
Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy
Siefert AL, Caplan MJ, Fahmy TM. Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy. Biomaterials 2016, 97: 85-96. PMID: 27162077, PMCID: PMC5999034, DOI: 10.1016/j.biomaterials.2016.03.039.Peer-Reviewed Original ResearchConceptsMonophosphoryl lipid APathogen-associated molecular patternsT cell responsesToll-like receptorsAntigen-specific T-helper 1Antigen-specific T cell responsesCell responsesMolecular patternsAntibody-mediated responsesT helper 1Model antigen ovalbuminBacterial pathogen-associated molecular patternsCytokine profileAntigen-loaded nanoparticlesTLR ligandsCellular immunityHelper 1Vaccine efficacyAntigen ovalbuminVaccine platformImmune responseNanoparticulate vaccinesLipid AOvalbuminCpG
2010
TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis
Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis. The Journal Of Immunology 2010, 185: 2989-2997. PMID: 20660705, PMCID: PMC3753007, DOI: 10.4049/jimmunol.1000768.Peer-Reviewed Original ResearchConceptsBiodegradable nanoparticlesUnmodified nanoparticlesImmune responseNanoparticlesCell-mediated immune responsesRobust humoral responseTh1 immune responseEffector T cellsAg-specific lymphocytesTh2-biased responsesAdjuvant aluminum hydroxideWest Nile encephalitisVirus encephalitisWest Nile virusAgHumoral responseCpG oligodeoxynucleotideT cellsMouse modelLive virusInfectious agentsProtein AgVaccine developmentWN virusNile virus