2016
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy
Srivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA. Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. Journal Of Allergy And Clinical Immunology 2016, 138: 536-543.e4. PMID: 27130858, DOI: 10.1016/j.jaci.2016.01.047.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral peanut challengesPeanut-specific immunotherapyPeanut allergyOral immunotherapyPeanut challengeSymptom scoresRecall responsesMurine modelSplenocyte culturesHistamine levelsPeanut-specific serum IgEC3H/HeJ miceIFN-γ levelsPlasma histamine levelsVehicle control animalsCytokine recall responsesLower symptom scoresBody temperatureCurrent clinical approachesOral sensitizationWeekly gavageIgG2a levelsSublingual immunotherapySerum IgE
2010
Targeting Toll-like receptors on dendritic cells modifies the TH2 response to peanut allergens in vitro
Pochard P, Vickery B, Berin MC, Grishin A, Sampson HA, Caplan M, Bottomly K. Targeting Toll-like receptors on dendritic cells modifies the TH2 response to peanut allergens in vitro. Journal Of Allergy And Clinical Immunology 2010, 126: 92-97.e5. PMID: 20538332, PMCID: PMC2902661, DOI: 10.1016/j.jaci.2010.04.003.Peer-Reviewed Original ResearchConceptsToll-like receptorsCrude peanut extractDendritic cellsT cellsBacterial adjuvantDC maturationCytokine productionBone marrow-derived dendritic cellsMarrow-derived dendritic cellsDelivery of allergensFood allergy treatmentOngoing allergic responseSuccessful immunotherapeutic strategiesIFN-gamma levelsT cell responsesPrimed T cellsT cell proliferationInnate immune systemCarboxyfluorescein succinimidyl esterAllergen immunotherapySensitized miceBioPlex assayIL-17Immunotherapeutic strategiesTh2 responses