2010
The cell biology of polycystic kidney disease
Chapin HC, Caplan MJ. The cell biology of polycystic kidney disease. Journal Of Cell Biology 2010, 191: 701-710. PMID: 21079243, PMCID: PMC2983067, DOI: 10.1083/jcb.201006173.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGTP-Binding ProteinsHumansKidneyModels, MolecularPolycystic Kidney, Autosomal DominantSignal TransductionTRPP Cation ChannelsWnt ProteinsConceptsCell growth controlCell biological processesPolycystic kidney diseaseCell biologyBiological processesGrowth controlPKD2 geneFluid-filled cystsNovel therapeutic targetGenetic defectsAutosomal dominant polycystic kidney diseaseCommon genetic disorderNormal renal tubulesDominant polycystic kidney diseaseGenetic disordersTherapeutic targetDisease pathogenesisKidney diseaseMorphogenesisGenesNew lightPKD1BiologyMutationsRenal tubules
1995
Developmental regulation of membrane protein sorting in Drosophila embryos
Shiel MJ, Caplan MJ. Developmental regulation of membrane protein sorting in Drosophila embryos. American Journal Of Physiology 1995, 269: c207-c216. PMID: 7631747, DOI: 10.1152/ajpcell.1995.269.1.c207.Peer-Reviewed Original ResearchConceptsDrosophila embryosMembrane proteinsSurface ectodermTransgenic Drosophila embryosVesicular stomatitis virus G proteinDrosophila melanogaster embryosMammalian epithelial cellsPlacental alkaline phosphataseApical plasma membraneVirus G proteinBasolateral proteinsSorting pathwaysCytosolic portionDevelopmental regulationHuman placental alkaline phosphatasePlasma membraneBasolateral distributionChimeric constructsSubcellular distributionG proteinsApical membraneInternal epitheliumEmbryosProteinApical surface