Implications of AMPK in the Formation of Epithelial Tight Junctions
Rowart P, Wu J, Caplan MJ, Jouret F. Implications of AMPK in the Formation of Epithelial Tight Junctions. International Journal Of Molecular Sciences 2018, 19: 2040. PMID: 30011834, PMCID: PMC6073107, DOI: 10.3390/ijms19072040.Peer-Reviewed Original ResearchConceptsTJ assemblyPlasma membraneAMPK activationUbiquitous serine/threonine kinaseSerine/threonine kinaseBaso-lateral domainTight junctionsImplication of AMPKSelective paracellular permeabilityCell polarityThreonine kinaseDisruption of TJsProtein kinaseEnergy sensorTJ regulationΓ subunitMembrane componentsZO-1 distributionAssembly/AMPKEpithelial tight junctionsEssential roleZonula occludensKinaseEpithelial cells