2024
Editorial: Molecular mechanisms underlying polycystic kidney disease: from the smallest bricks to the big scenario
Di Mise A, Caplan M, Valenti G. Editorial: Molecular mechanisms underlying polycystic kidney disease: from the smallest bricks to the big scenario. Frontiers In Molecular Biosciences 2024, 11: 1429206. PMID: 38836108, PMCID: PMC11149700, DOI: 10.3389/fmolb.2024.1429206.Peer-Reviewed Original ResearchMolecular mechanismsPolycystic kidney disease
2018
Metabolism and mitochondria in polycystic kidney disease research and therapy
Padovano V, Podrini C, Boletta A, Caplan MJ. Metabolism and mitochondria in polycystic kidney disease research and therapy. Nature Reviews Nephrology 2018, 14: 678-687. PMID: 30120380, DOI: 10.1038/s41581-018-0051-1.Peer-Reviewed Original ResearchConceptsPolycystic kidney disease 1Polycystin-1Autosomal dominant polycystic kidney diseaseHallmark of ADPKDFluid-filled renal cystsPolycystin proteinsADPKD cellsPKD genesMolecular mechanismsOxidative phosphorylationCell metabolismRegulatory rolePhysiological functionsADPKD pathogenesisEnergy metabolismPotential therapeutic targetMonogenic diseasesEnergy productionMitochondriaDominant polycystic kidney diseasePolycystic kidney diseaseTherapeutic targetMutationsAlternative pathwayMetabolism
1999
Regulation of myocardial glucose uptake and transport during ischemia and energetic stress
Young L, Russell R, Yin R, Caplan M, Ren J, Bergeron R, Shulman G, Sinusas A. Regulation of myocardial glucose uptake and transport during ischemia and energetic stress. The American Journal Of Cardiology 1999, 83: 25-30. PMID: 10750583, DOI: 10.1016/s0002-9149(99)00253-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEnergetic stressEnergy-generating metabolic pathwaysMonophosphate-activated protein kinaseGlucose uptakeGlucose transport proteinProtein kinaseTransporter translocationTransport proteinsMolecular mechanismsMetabolic pathwaysCardiac glucose uptakeGlucose transporterCellular mechanismsGlucose transportFuel gaugeKinaseTranslocationGlucose entryModerate regional ischemiaSubsequent metabolismGlucose utilization increasesImportant roleUptakeGLUT4Stress
1995
The generation of epithelial polarity in mammalian and Drosophila embryos
Shiel M, Caplan M. The generation of epithelial polarity in mammalian and Drosophila embryos. Seminars In Cell And Developmental Biology 1995, 6: 39-46. DOI: 10.1016/s1044-5781(06)80083-6.Peer-Reviewed Original Research