2018
Implications of AMPK in the Formation of Epithelial Tight Junctions
Rowart P, Wu J, Caplan MJ, Jouret F. Implications of AMPK in the Formation of Epithelial Tight Junctions. International Journal Of Molecular Sciences 2018, 19: 2040. PMID: 30011834, PMCID: PMC6073107, DOI: 10.3390/ijms19072040.Peer-Reviewed Original ResearchConceptsTJ assemblyPlasma membraneAMPK activationUbiquitous serine/threonine kinaseSerine/threonine kinaseBaso-lateral domainTight junctionsImplication of AMPKSelective paracellular permeabilityCell polarityThreonine kinaseDisruption of TJsProtein kinaseEnergy sensorTJ regulationΓ subunitMembrane componentsZO-1 distributionAssembly/AMPKEpithelial tight junctionsEssential roleZonula occludensKinaseEpithelial cells
1987
Dependence on pH of polarized sorting of secreted proteins
Caplan M, Stow J, Newman A, Madri J, Anderson H, Farquhar M, Palade G, Jamieson J. Dependence on pH of polarized sorting of secreted proteins. Nature 1987, 329: 632-635. PMID: 2821405, DOI: 10.1038/329632a0.Peer-Reviewed Original ResearchConceptsSecretory proteinsMDCK cellsDifferent protein compositionsBasolateral cell surfacePolarized sortingMembrane proteinsBasolateral domainDefault pathwayPlasma membraneAcidic intracellular compartmentsIntracellular compartmentsProtein compositionMembrane componentsCell surfaceBasement membrane componentsProteinSecrete lamininDistinct setsRenal tubule cellsEpithelial cellsActive sortingBasolateral compartmentCellsSecretory productsSpecific regions