2016
The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function
Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ. The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Molecular Biology Of The Cell 2016, 28: 261-269. PMID: 27881662, PMCID: PMC5231895, DOI: 10.1091/mbc.e16-08-0597.Peer-Reviewed Original ResearchConceptsPolycystin-1Polycystin-2Cellular oxygen-sensing pathwaysMitochondrial functionOxygen-sensing pathwayBroad physiological rolesProlyl hydroxylase domainCellular energy metabolismPolycystin complexIon channel complexEndoplasmic reticulum CaPC1 expressionSubcellular localizationHydroxylase domainMitochondrial CaER CaNovel rolePhysiological roleEnergy metabolismChannel complexChannel activityPolycystinsAutosomal dominant polycystic kidney diseaseReticulum CaDominant polycystic kidney disease
2008
Epithelial junctions and polarity: complexes and kinases
Caplan MJ, Seo-Mayer P, Zhang L. Epithelial junctions and polarity: complexes and kinases. Current Opinion In Nephrology & Hypertension 2008, 17: 506-512. PMID: 18695392, PMCID: PMC3057677, DOI: 10.1097/mnh.0b013e32830baaae.Peer-Reviewed Original ResearchConceptsEpithelial cell polarityCell polarityEpithelial cell polarizationJunctional complexesIntercellular adhesion junctionsImportant physiological ramificationsCalcium-dependent adhesion proteinCell-cell contactCellular energy metabolismProtein complexesMembrane proteinsAdhesion junctionsPlasmalemmal domainsAdhesion proteinsCell polarizationPhysiological ramificationsEpithelial junctionsKinaseEnergy metabolismCharacteristic polarityEpithelial cellsProteinParacellular permeabilityNovel classComplexes