2017
The secretory pathway at 50: a golden anniversary for some momentous grains of silver
Matlin KS, Caplan MJ. The secretory pathway at 50: a golden anniversary for some momentous grains of silver. Molecular Biology Of The Cell 2017, 28: 229-232. PMID: 28082520, PMCID: PMC5231891, DOI: 10.1091/mbc.e16-07-0508.Peer-Reviewed Original ResearchConceptsSecretory pathwayBiosynthetic machineryMembrane protein trafficSpecialized cell typesCell's biosynthetic machineryModern cell biologyProtein trafficCell biologyCell typesMorphological methodologiesPathological consequencesPathwayMachineryCentral paradigmBiologyDynamic natureSecretoryCulmination of decadesCellsAdaptationDiscovery
2010
The cell biology of polycystic kidney disease
Chapin HC, Caplan MJ. The cell biology of polycystic kidney disease. Journal Of Cell Biology 2010, 191: 701-710. PMID: 21079243, PMCID: PMC2983067, DOI: 10.1083/jcb.201006173.Peer-Reviewed Original ResearchConceptsCell growth controlCell biological processesPolycystic kidney diseaseCell biologyBiological processesGrowth controlPKD2 geneFluid-filled cystsNovel therapeutic targetGenetic defectsAutosomal dominant polycystic kidney diseaseCommon genetic disorderNormal renal tubulesDominant polycystic kidney diseaseGenetic disordersTherapeutic targetDisease pathogenesisKidney diseaseMorphogenesisGenesNew lightPKD1BiologyMutationsRenal tubules
2000
The cell biology of ion pumps: sorting and regulation
Dunbar L, Caplan M. The cell biology of ion pumps: sorting and regulation. European Journal Of Cell Biology 2000, 79: 557-563. PMID: 11001492, DOI: 10.1078/0171-9335-00079.Peer-Reviewed Original ResearchConceptsP-type familyPolarized epithelial cellsIon pumpsK-ATPaseDistinct regulatory pathwaysProtein traffickingSubcellular localizationCell biologyRelated membersRegulatory pathwaysMolecular signalsCellular mechanismsEnzymatic activityIntra-molecular interactionsEpithelial cellsTraffickingComplex arrayCatalytic capacityPhysiologic functionATPasesHomologyBiologyPathwayRegulationSorting