2020
Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
Wallach JD, Wang K, Zhang AD, Cheng D, Grossetta Nardini HK, Lin H, Bracken MB, Desai M, Krumholz HM, Ross JS. Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses. The BMJ 2020, 368: l7078. PMID: 32024657, PMCID: PMC7190063, DOI: 10.1136/bmj.l7078.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesHumansHypoglycemic AgentsInformation DisseminationRandomized Controlled Trials as TopicRisk FactorsRosiglitazoneConceptsIndividual patient-level dataCardiovascular related deathsCardiovascular riskMyocardial infarctionRelated deathsSummary-level dataHeart failureOdds ratioSystematic reviewIncreased cardiovascular riskMore myocardial infarctionsHeart failure eventsCochrane Central RegistryAcute myocardial infarctionMyocardial infarction eventsPatient-level dataRandom-effects modelWeb of ScienceAnalysis of trialsEligible trialsComposite outcomeAdverse eventsContinuity correctionControlled TrialsRosiglitazone treatment
2008
Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants
Görk A, Ehrenkranz R, Bracken M. Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants. Cochrane Database Of Systematic Reviews 2008, 2010: cd006071. PMID: 18254092, PMCID: PMC8912238, DOI: 10.1002/14651858.cd006071.pub2.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityCerebrovascular CirculationDuctus Arteriosus, PatentHumansIndomethacinInfant, NewbornInfant, PrematureInfusions, IntravenousInjections, IntravenousProstaglandin AntagonistsRandomized Controlled Trials as TopicConceptsSymptomatic patent ductus arteriosusPatent ductus arteriosusTreatment of PDAContinuous indomethacin infusionRetinopathy of prematurityPDA closurePreterm infantsBolus administrationBolus injectionBlood flowBronchopulmonary dysplasiaIndomethacin infusionIntraventricular hemorrhagePremature infantsContinuous infusionMesenteric circulationRelative riskRisk differencePatent ductus arteriosus closureCerebral blood flow velocityAdverse effectsCochrane Neonatal reviewsContinuous infusion groupIntermittent bolus dosesSymptomatic preterm infants
2001
Summary Statement: The Sygen® (GM-1 Ganglioside) Clinical Trial in Acute Spinal Cord Injury
Fehlings M, Bracken M. Summary Statement: The Sygen® (GM-1 Ganglioside) Clinical Trial in Acute Spinal Cord Injury. Spine 2001, 26: s99-s100. PMID: 11805615, DOI: 10.1097/00007632-200112151-00016.Commentaries, Editorials and LettersAcute DiseaseG(M1) GangliosideHumansMulticenter Studies as TopicNeuroprotective AgentsRandomized Controlled Trials as TopicSpinal Cord InjuriesTreatment OutcomeOn stratification, minimization and protection against types 1 and 2 error
Bracken M. On stratification, minimization and protection against types 1 and 2 error. Journal Of Clinical Epidemiology 2001, 54: 104-105. PMID: 11246516, DOI: 10.1016/s0895-4356(00)00286-9.Peer-Reviewed Original ResearchBiasData Interpretation, StatisticalGuidelines as TopicHumansLinear ModelsRandomized Controlled Trials as TopicReproducibility of ResultsResearch DesignSample Size
2000
Methylprednisolone and spinal cord injury.
Bracken M. Methylprednisolone and spinal cord injury. Journal Of Neurosurgery 2000, 93: 175-9. PMID: 10879779, DOI: 10.3171/spi.2000.93.1.0175.Commentaries, Editorials and LettersClinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
Bracken M, Aldrich E, Herr D, Hitchon P, Holford T, Marshall L, Nockels R, Pascale V, Shepard M, Sonntag V, Winn H, Young W. Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury. Journal Of Trauma And Acute Care Surgery 2000, 48: 558-561. PMID: 10744306, DOI: 10.1097/00005373-200003000-00036.Commentaries, Editorials and LettersConceptsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyClinical measurementsHigh-dose methylprednisoloneSecondary neuronal damageSpinal cord injuryRisk benefitNeuronal damageFunctional recoverySafety profileCord injuryPharmacologic agentsSpinal injuryInjury studiesInnovative therapiesTrialsStatistical analysisInjuryMulticenterMethylprednisoloneSeries of trialsTherapyPrevention
1997
Introduction to Neonatal Systematic Reviews
Sinclair J, Bracken M, Horbar J, Soll R. Introduction to Neonatal Systematic Reviews. Pediatrics 1997, 100: 892-895. PMID: 9346993, DOI: 10.1542/peds.100.5.892.Commentaries, Editorials and LettersEvidence-Based MedicineHumansMeta-Analysis as TopicNeonatologyRandomized Controlled Trials as TopicReproducibility of ResultsReview Literature as TopicData From Randomized Trial Networks: When Less Is More
Bracken M. Data From Randomized Trial Networks: When Less Is More. Pediatrics 1997, 99: 250-251. PMID: 9024455, DOI: 10.1542/peds.99.2.250.Commentaries, Editorials and Letters
1994
Clinically useful measures of effect in binary analyses of randomized trials
Sinclair J, Bracken M. Clinically useful measures of effect in binary analyses of randomized trials. Journal Of Clinical Epidemiology 1994, 47: 881-889. PMID: 7730891, DOI: 10.1016/0895-4356(94)90191-0.Peer-Reviewed Original ResearchMeSH KeywordsHumansMeta-Analysis as TopicOutcome Assessment, Health CareRandomized Controlled Trials as TopicRiskConceptsOdds ratioTreatment effectsHigher baseline riskRelative risk reductionRandomized clinical trialsControl group risksGroups of trialsLarge treatment effectsPhysician appreciationRandomized trialsRisk ratioClinical trialsRelative riskBaseline riskTreatment decisionsClinical questionsRisk differenceTrialsSingle trialRisk reductionRiskGroup riskPhysiciansAbsolute effectUseful measure
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose