1994
The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatment.
Duh M, Shepard M, Wilberger J, Bracken M. The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatment. Neurosurgery 1994, 35: 240-8; discussion 248-9. PMID: 7969831, DOI: 10.1227/00006123-199408000-00009.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryPharmacological treatmentSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudySevere spinal cord injuryTraumatic spinal cord injuryValue of surgeryRole of surgeryEffectiveness of surgerySpinal cord surgeryNASCIS IINeurological improvementEarly surgeryIncomplete injuriesNeurological recoveryNeurological scoreLate surgeryCord surgeryRandomized studySurgical treatmentMotor scores
1993
Pharmacological treatment of acute spinal cord injury: current status and future projects.
Bracken M. Pharmacological treatment of acute spinal cord injury: current status and future projects. Journal Of Emergency Medicine 1993, 11 Suppl 1: 43-8. PMID: 8445202.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injurySecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyEffectiveness of methylprednisoloneMethylprednisolone-treated patientsRecovery of motorHours of injuryLevel of injuryMethylprednisolone groupPinprick sensationTirilazad mesylateMethylprednisolone infusionGlucocorticoid activityInitial bolusNeurological functionPharmacological treatmentMotor functionSpinal cordInjury studiesSensory functionInjury
1992
The Second National Acute Spinal Cord Injury Study.
Young W, Bracken M. The Second National Acute Spinal Cord Injury Study. Journal Of Neurotrauma 1992, 9 Suppl 1: s397-405. PMID: 1588630.Peer-Reviewed Original ResearchConceptsSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injuryNeurologic scoresCord injuryInjury studiesHuman spinal cord injurySpinal cord injury careSevere spinal cord injuryBeneficial effectsSignificant beneficial effectNeurologic recoverySuch patientsPatient populationInjury careLumbosacral segmentsFunctional assessmentLesion siteInjury severityPatientsSensory functionMultivariate analysisMethylprednisoloneMethylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function