2001
Methylprednisolone and Acute Spinal Cord Injury
Bracken M. Methylprednisolone and Acute Spinal Cord Injury. Spine 2001, 26: s47-s54. PMID: 11805609, DOI: 10.1097/00007632-200112151-00010.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryMethodologic qualitySystematic reviewImproved functional recoveryHigh methodologic qualityNeurologic recoveryClinical recoveryPharmacologic therapyFunctional recoveryRandomized trialsInjury trialsCochrane LibraryEffective therapySurgical trialsEarly treatmentFurther trialsTherapeutic interventionsInjuryMeSH headingsMethylprednisoloneScore improvementPatientsEvidence base
2000
Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
Bracken M, Aldrich E, Herr D, Hitchon P, Holford T, Marshall L, Nockels R, Pascale V, Shepard M, Sonntag V, Winn H, Young W. Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury. Journal Of Trauma And Acute Care Surgery 2000, 48: 558-561. PMID: 10744306, DOI: 10.1097/00005373-200003000-00036.Commentaries, Editorials and LettersConceptsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyClinical measurementsHigh-dose methylprednisoloneSecondary neuronal damageSpinal cord injuryRisk benefitNeuronal damageFunctional recoverySafety profileCord injuryPharmacologic agentsSpinal injuryInjury studiesInnovative therapiesTrialsStatistical analysisInjuryMulticenterMethylprednisoloneSeries of trialsTherapyPrevention
1998
Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury
BRACKEN M, SHEPARD M, HOLFORD T, LEO-SUMMERS L, ALDRICH E, FAZL M, FEHLINGS M, HERR D, HITCHON P, MARSHALL L, NOCKELS R, PASCALE V, PEROT P, PIEPMEIER J, SONNTAG V, WAGNER F, WILBERGER J, WINN H, YOUNG W. Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury. Survey Of Anesthesiology 1998, 42: 197. DOI: 10.1097/00132586-199808000-00011.Peer-Reviewed Original Research
1993
Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2.
Bracken M, Holford T. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. Journal Of Neurosurgery 1993, 79: 500-7. PMID: 8410217, DOI: 10.3171/jns.1993.79.4.0500.Peer-Reviewed Original ResearchConceptsNational Acute Spinal Cord Injury StudyNeurological recoveryIncomplete injuriesNeurological functionNaloxone administrationClinical managementAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneLong spinal tractsHours of injuryUltimate therapeutic goalInjury levelConsiderable clinical significanceNarrow treatment windowMethylprednisolone treatmentSpinal tractClinical significanceSegmental functionInjury studiesTherapeutic goalsTreatment windowMethylprednisoloneHigh dosesInjury
1992
The Second National Acute Spinal Cord Injury Study.
Young W, Bracken M. The Second National Acute Spinal Cord Injury Study. Journal Of Neurotrauma 1992, 9 Suppl 1: s397-405. PMID: 1588630.Peer-Reviewed Original ResearchConceptsSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injuryNeurologic scoresCord injuryInjury studiesHuman spinal cord injurySpinal cord injury careSevere spinal cord injuryBeneficial effectsSignificant beneficial effectNeurologic recoverySuch patientsPatient populationInjury careLumbosacral segmentsFunctional assessmentLesion siteInjury severityPatientsSensory functionMultivariate analysisMethylprednisoloneMethylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1991
Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial.
Bracken M. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. Journal Of Neurotrauma 1991, 8 Suppl 1: s47-50; discussion s51-2. PMID: 1920461.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryAdministration of methylprednisoloneApparent contraindicationsNeurological improvementClinical trialsPermanent paralysisMethylprednisoloneLow dosesInjuryAdministrationDosesTrialsTreatmentMulticenterPlaceboContraindicationsNaloxoneParalysisDoseA Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
BRACKEN M, SHEPARD M, COLLINS W, HOLFORD T, YOUNG W, BASKIN D, EISENBERG H, FLAMM E, LEOSUMMERS L, MAROON J, MARSHALL L, PEROT P, PIEPMEIER J, SONNTAG V, WAGNER F, WILBERGER J, WINN H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. Survey Of Anesthesiology 1991, 35: 50. DOI: 10.1097/00132586-199102000-00048.Peer-Reviewed Original Research
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1985
Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Hellenbrand K, Collins W, Leo L, Freeman D, Wagner F, Flamm E, Eisenberg H, Goodman J, Perot P, Green B, Grossman R, Meagher J, Young W, Fischer B, Clifton G, Hunt W, Rifkinson N. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1985, 63: 704-13. PMID: 3903070, DOI: 10.3171/jns.1985.63.5.0704.Peer-Reviewed Original ResearchConceptsTotal steroid doseNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneSteroid treatment protocolFunction 1 yearCase fatality rateSpinal cord injuryPinprick responseSteroid doseNeurological recoveryCord injuryStandard dosePatient genderClinical trialsMotor functionTreatment protocolStudy groupInjury studiesTreatment groupsFatality rateInjuryMethylprednisoloneTreatment effects
1984
Efficacy of Methylprednisolone in Acute Spinal Cord Injury
Bracken M, Collins W, Freeman D, Shepard M, Wagner F, Silten R, Hellenbrand K, Ransohoff J, Hunt W, Perot P, Grossman R, Green B, Eisenberg H, Rifkinson N, Goodman J, Meagher J, Fischer B, Clifton G, Flamm E, Rawe S. Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA 1984, 251: 45-52. PMID: 6361287, DOI: 10.1001/jama.1984.03340250025015.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryEarly case fatalityEfficacy of methylprednisoloneHigh-dose regimenLight touch sensationHigh-dose protocolGroups six weeksNeurological recoveryCase fatalityWound infectionStandard doseMotor functionInitial lesionHigh doseOperative siteSix weeksInjuryMethylprednisoloneTreatment effectsTouch sensationDoseEfficacyMulticenter