2018
Editorial: Can omega‐3 fatty acids improve executive functioning? Will this reduce ADHD and depression?
Artukoglu BB, Bloch MH. Editorial: Can omega‐3 fatty acids improve executive functioning? Will this reduce ADHD and depression? Journal Of Child Psychology And Psychiatry 2018, 59: 615-617. PMID: 29808491, DOI: 10.1111/jcpp.12932.Peer-Reviewed Original ResearchChapter 17 Managing a Child With OCD Who Is Treatment Refractory
Bloch M. Chapter 17 Managing a Child With OCD Who Is Treatment Refractory. 2018, 329-356. DOI: 10.1016/b978-0-12-811427-8.00017-4.Peer-Reviewed Original ResearchObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderCognitive behavioral therapyFirst-line treatmentOCD symptomsPediatric obsessive-compulsive disorderSelective serotonin reuptake inhibitor (SSRI) pharmacotherapyEffective first-line treatmentSelective serotonin reuptake inhibitorsIntensive treatment programSerotonin reuptake inhibitorsGlutamate-modulating agentsMajority of childrenTreatment programAntipsychotic augmentationReuptake inhibitorsTreatment refractoryPharmacological treatmentAvailable treatmentsChildrenSubstantial proportionPharmacotherapyTreatmentTherapySymptoms
2017
Antipsychotics for aggression in adults: A meta-analysis
van Schalkwyk GI, Beyer C, Johnson J, Deal M, Bloch MH. Antipsychotics for aggression in adults: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 81: 452-458. PMID: 28754408, DOI: 10.1016/j.pnpbp.2017.07.019.Peer-Reviewed Original ResearchConceptsTreatment of aggressionAntipsychotic medicationNon-pharmacologic interventionsEffect sizeChoice of agentSignificant dose effectSignificant morbidityCochrane LibraryAntipsychotic agentsDopamine antagonistsPsychiatric illnessIrritable moodMultiple diagnosesClinical decisionAntipsychoticsSpecific agentsSearch termsSmall effect sizesDiagnosisDose effectMedicationsSymptom dimensionsAggressive behaviorTreatmentAdults
2016
Commentary: Are alpha‐2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016)
Bloch MH. Commentary: Are alpha‐2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016). Journal Of Child Psychology And Psychiatry 2016, 57: 1005-1007. PMID: 27535650, DOI: 10.1111/jcpp.12592.Peer-Reviewed Original ResearchConceptsAlpha-2 agonistsComorbid ADHDComprehensive Behavioral InterventionAdrenergic receptor agonistAgonist medicationsAntipsychotic medicationReceptor agonistPrimary treatmentTic disordersSystematic reviewMedicationsBehavioral interventionsAgonistsEffects of ADHDEfficacyTreatmentADHDChildrenPossible explanationPatients
2015
Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder
Coughlin CG, Cohen SC, Mulqueen JM, Ferracioli-Oda E, Stuckelman ZD, Bloch MH. Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder. Journal Of Child And Adolescent Psychopharmacology 2015, 25: 611-617. PMID: 26402485, PMCID: PMC4617411, DOI: 10.1089/cap.2015.0075.Peer-Reviewed Original ResearchConceptsRisk of anxietyAttention-deficit/hyperactivity disorderPsychostimulant treatmentSide effectsHyperactivity disorderPlacebo-controlled trialStratified subgroup analysisTreatment of childrenDuration of useRisk ratioSubgroup analysisPsychostimulant medicationPlaceboPubMed searchTrial designNumber of childrenHigh dosesStimulant typePsychostimulantsAnxiety symptomsTreatmentChildrenRiskSymptomsAnxiety
2014
Pharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger C, Bloch MH. Pharmacological Treatment of Obsessive-Compulsive Disorder. Psychiatric Clinics Of North America 2014, 37: 375-391. PMID: 25150568, PMCID: PMC4143776, DOI: 10.1016/j.psc.2014.05.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPharmacological treatmentLow-dose neuroleptic medicationsSelective serotonin reuptake inhibitorsProfound clinical challengeSecond-line treatmentSerotonin reuptake inhibitorsSignificant symptomatic reliefTricyclic clomipramineAppropriate pharmacotherapyNeuroleptic medicationReuptake inhibitorsSubstantial morbiditySymptomatic reliefAvailable treatmentsClinical challengeHigh dosesOCD refractoryTreatmentDisordersMedicationsMorbidityPharmacotherapyPatientsClomipramineMeta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive–compulsive disorder
Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A, Pittenger C, Leckman JF. Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive–compulsive disorder. Molecular Psychiatry 2014, 19: 1025-1030. PMID: 24912494, PMCID: PMC4169729, DOI: 10.1038/mp.2014.50.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment responseOCD patientsOdds ratioFurther treatment researchCase-control studyPoor treatment outcomesDifferential treatment responseSymptoms of OCDPrimary outcomeTreatment modalitiesEligible studiesTreatment outcomesPatientsElectronic searchSymptomsTotal participantsBehavioral therapyOCD treatmentDisordersSymptom dimensionsTreatment researchDSM-5Hoarding symptomsTreatment
2012
Pharmacologic Treatment of Repetitive Behaviors in Autism Spectrum Disorders: Evidence of Publication Bias
Carrasco M, Volkmar FR, Bloch MH. Pharmacologic Treatment of Repetitive Behaviors in Autism Spectrum Disorders: Evidence of Publication Bias. Pediatrics 2012, 129: e1301-e1310. PMID: 22529279, PMCID: PMC3340598, DOI: 10.1542/peds.2011-3285.Peer-Reviewed Original ResearchConceptsSerotonin receptor inhibitorsPublication biasTrial resultsPlacebo-controlled trialAutism spectrum disorderRepetitive behaviorsAvailable medicationsPatient agePharmacologic treatmentPrimary outcomeUnpublished trialsEgger's testReceptor inhibitorsMean improvementSpectrum disorderFunnel plotTrial designSecondary analysisTrial durationRating ScaleEfficacyTrialsTweedie's trimMedicationsTreatment
2008
Emerging treatments for Tourette’s disorder
Bloch MH. Emerging treatments for Tourette’s disorder. Current Psychiatry Reports 2008, 10: 323. PMID: 18627671, DOI: 10.1007/s11920-008-0052-z.Peer-Reviewed Original ResearchConceptsTourette's disorderRepetitive transcranial magnetic stimulationChildhood-onset neuropsychiatric disorderHabit reversal therapyDeep brain stimulationTranscranial magnetic stimulationReversal therapyVocal ticsCurrent treatmentSevere symptomsMagnetic stimulationBrain stimulationSignificant disabilityNeuropsychiatric disordersEvidence baseDisordersTreatmentStimulationTherapySymptomsMultiple motors