Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: A translational meta-analysis of rodent and human studies
Lewis AS, van Schalkwyk GI, Bloch MH. Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: A translational meta-analysis of rodent and human studies. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 75: 45-53. PMID: 28065843, PMCID: PMC5446073, DOI: 10.1016/j.pnpbp.2017.01.001.Peer-Reviewed Original ResearchConceptsCognitive dysfunctionAlzheimer's diseaseClinical trialsHuman studiesΑ7 nicotinic acetylcholine receptorPreclinical behavioral testsPlacebo-controlled trialMultiple clinical trialsNicotinic acetylcholine receptorsEffect sizeDrug development targetsΑ7 agonistsFunctional disabilityCochrane LibraryΑ7 nAChRsNicotinic agonistsRodent studiesTherapeutic targetAnimal modelsCurrent therapeuticsLarge effect sizesΑ7 nAChR.Acetylcholine receptorsPartial agonistBehavioral tests