Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains
Alfajaro M, Kim J, Barbé L, Cho E, Park J, Soliman M, Baek Y, Kang M, Kim S, Kim G, Park S, Le Pendu J, Cho K. Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains. Journal Of Virology 2019, 93: 10.1128/jvi.00941-19. PMID: 31243129, PMCID: PMC6714814, DOI: 10.1128/jvi.00941-19.Peer-Reviewed Original ResearchConceptsHisto-blood group antigensRotaTeq vaccineIntestinal epithelial cellsAlternative receptorSialic acidVaccine strainGroup antigensSevere rotavirus diseaseEpithelial cellsHuman intestinal epithelial cellsHuman small intestinal epithelial cellsNatural human infectionBearing strainsSmall intestinal epithelial cellsRotaTeq vaccine strainsMA-104 cellsTight junction proteinsGroup A rotavirusesRotavirus diseaseSevere diarrheaIntestinal enteroidsGroup ASurface sialic acidΑGal epitopesImportant causeDevelopment of a live attenuated trivalent porcine rotavirus A vaccine against disease caused by recent strains most prevalent in South Korea
Park J, Alfajaro M, Cho E, Kim J, Soliman M, Baek Y, Park C, Lee J, Son K, Cho K, Kang M. Development of a live attenuated trivalent porcine rotavirus A vaccine against disease caused by recent strains most prevalent in South Korea. Veterinary Research 2019, 50: 2. PMID: 30616694, PMCID: PMC6323864, DOI: 10.1186/s13567-018-0619-6.Peer-Reviewed Original ResearchConceptsVaccine strainTrivalent vaccineKorean swine industrySevere economic lossesHomologous virulent strainPorcine rotavirusSwine industryEconomic lossesSerum virus-neutralizing antibodiesExperimental pigletsVirulent strainCell culture passageFecal secretory IgAChallenge exposureVirus-neutralizing antibodiesRecent strainsPigletsVirulentConsecutive passagesRotavirus diseaseIgA levelsRotavirus vaccineOral immunizationHistopathological lesionsVaccine