2014
Comparison of pathogenicities and nucleotide changes between porcine and bovine reassortant rotavirus strains possessing the same genotype constellation in piglets and calves
Park J, Kim D, Matthijnssens J, Kwon H, Zeller M, Alfajaro M, Son K, Hosmillo M, Ryu E, Kim J, Lee J, Park S, Kang M, Kwon J, Choi J, Cho K. Comparison of pathogenicities and nucleotide changes between porcine and bovine reassortant rotavirus strains possessing the same genotype constellation in piglets and calves. Veterinary Microbiology 2014, 172: 51-62. PMID: 24861840, DOI: 10.1016/j.vetmic.2014.04.010.Peer-Reviewed Original ResearchConceptsHost range restrictionGenotype constellationHistopathological changesCritical molecular determinantsSmall intestineReassortant rotavirusesComparison of pathogenicityDiarrheic pigletsPathological phenotypesDifferent virulenceReassortant strainsPigletsCalvesNSP4 genesSpecific mutationsAmino acid substitutionsRotavirus evolutionMolecular determinantsNSP3 genePathogenicityVirulenceAcid substitutionsNucleotide changesDiarrheaRotavirusEvidences and consequences of extra-intestinal spread of rotaviruses in humans and animals
Alfajaro M, Cho K. Evidences and consequences of extra-intestinal spread of rotaviruses in humans and animals. VirusDisease 2014, 25: 186-194. PMID: 25674584, PMCID: PMC4188184, DOI: 10.1007/s13337-014-0197-9.Peer-Reviewed Original Research
2013
Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves
Park J, Kim H, Matthijnssens J, Alfajaro M, Kim D, Son K, Kwon H, Hosmillo M, Ryu E, Kim J, Cena R, Lee J, Kang M, Park S, Cho K. Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves. Veterinary Research 2013, 44: 88. PMID: 24083947, PMCID: PMC3851489, DOI: 10.1186/1297-9716-44-88.Peer-Reviewed Original ResearchConceptsHistopathological changesSmall intestineGroup A rotavirusesDirect interspecies transmissionGenotype constellationCritical molecular determinantsFull-length sequencing analysisA rotavirusesBovine rotavirusVP1-VP4Pathological phenotypesDifferent virulencePigletsDiarrheaInterspecies transmissionAmino acid mutationsRotavirusCalvesIntestineSpecific mutationsTropismMolecular determinantsSequencing analysisUntranslated regionPorcine
2012
Pathogenicity characterization of a bovine triple reassortant rotavirus in calves and piglets
Kim H, Park J, Alfajaro M, Kim D, Hosmillo M, Son K, Lee J, Bae Y, Park S, Kang M, Cho K. Pathogenicity characterization of a bovine triple reassortant rotavirus in calves and piglets. Veterinary Microbiology 2012, 159: 11-22. PMID: 22465801, DOI: 10.1016/j.vetmic.2012.03.017.Peer-Reviewed Original ResearchConceptsExtra-intestinal organsMesenteric lymph nodesCross-species pathogenicityReassortant rotavirusesLymph nodesIntestinal pathologyPersistent severe diarrheaSevere intestinal pathologyExtra-intestinal infectionsDiarrhea fecal samplesReal-time RT-PCRGreen real-time RT-PCRSYBR Green real-time RT-PCRSevere diarrheaCerebrospinal fluidChoroid plexusViral replicationRotavirusRT-PCRViral RNAFecal samplesPigletsDiarrheaPublic healthPathology