2014
Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract
Alfajaro M, Rho M, Kim H, Park J, Kim D, Hosmillo M, Son K, Lee J, Park S, Kang M, Ryu Y, Park K, Oh H, Lee S, Park S, Lee W, Cho K. Anti-rotavirus effects by combination therapy of stevioside and Sophora flavescens extract. Research In Veterinary Science 2014, 96: 567-575. PMID: 24704033, DOI: 10.1016/j.rvsc.2014.03.011.Peer-Reviewed Original ResearchConceptsCombination therapyAnti-rotaviral activityAnti-rotavirus effectIntestinal lesion scoresLethal dose 50Rotavirus enteritisCurative medicationsRotaviral enteritisSophora flavescensRotaviral diarrheaOrgan weightsPiglet modelPathological changesFecal virusBody weightTherapyVirus replicationLesion scoresSingle treatmentDose 50Porcine rotavirusAdverse effectsPreliminary dataDiarrheaEnteritis
2012
Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea
Alfajaro M, Kim H, Park J, Ryu E, Kim J, Jeong Y, Kim D, Hosmillo M, Son K, Lee J, Kwon H, Ryu Y, Park S, Park S, Lee W, Cho K. Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea. Virology Journal 2012, 9: 310. PMID: 23244491, PMCID: PMC3547719, DOI: 10.1186/1743-422x-9-310.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsCell LineColostrumDiarrheaDose-Response Relationship, DrugDrug Evaluation, PreclinicalFecesGlycyrrhiza uralensisInterleukin-8Intestine, SmallMAP Kinase Signaling SystemModels, AnimalNF-kappa BPhytotherapyPlant ExtractsPlant RootsRNA, MessengerRotavirusRotavirus InfectionsSpleenSwineSwine DiseasesTumor Necrosis Factor-alphaVirus SheddingConceptsInflammation-related cytokinesGlycyrrhiza uralensis extractMRNA expression levelsSmall intestineRotavirus diarrheaRotaviral enteritisAnti-rotaviral effectAnti-inflammatory effectsFecal virus sheddingOnset of diarrheaColostrum-deprived pigletsExpression levelsIntestinal lesion scoresFecal consistency scoreAntiviral efficacyVirus sheddingHistological changesSevere gastroenteritisFecal virusAntiviral agentsDiarrheaLesion scoresViable medicationsHerbal medicineAntiviral properties