2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetuses
2015
Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis
Dulay AT, Buhimschi IA, Zhao G, Bahtiyar MO, Thung SF, Cackovic M, Buhimschi CS. Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis. Cytokine 2015, 76: 236-243. PMID: 25957466, PMCID: PMC4824401, DOI: 10.1016/j.cyto.2015.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidAsymptomatic InfectionsBiomarkersCalcitoninCalcitonin Gene-Related PeptideChorioamnionitisC-Reactive ProteinFemaleFetal BloodFetal Membranes, Premature RuptureHumansInfant, NewbornInterleukin-6Obstetric Labor, PrematurePlacentaPregnancyPregnancy Complications, InfectiousPremature BirthProtein PrecursorsSystemic Inflammatory Response SyndromeConceptsIntra-amniotic infectionC-reactive proteinSubclinical intra-amniotic infectionIL-6Blood IL-6 levelsBlood IL-6Maternal blood levelsSystemic inflammatory responseIL-6 levelsNon-invasive biomarkersSubgroup of casesChorioamnionitis groupHistological chorioamnionitisInflammatory markersPreterm laborCRP levelsInflammatory biomarkersMaternal serumPlacental pathologyAcute phasePregnant womenBlood levelsSubclinical phaseInterleukin-6Cord blood
2010
Interpretation of Amniotic Fluid White Blood Cell Count in “Bloody Tap” Amniocenteses in Women With Symptoms of Preterm Labor
Abdel-Razeq SS, Buhimschi IA, Bahtiyar MO, Rosenberg VA, Dulay AT, Han CS, Werner EF, Thung S, Buhimschi CS. Interpretation of Amniotic Fluid White Blood Cell Count in “Bloody Tap” Amniocenteses in Women With Symptoms of Preterm Labor. Obstetrics And Gynecology 2010, 116: 344-354. PMID: 20664395, PMCID: PMC4142228, DOI: 10.1097/aog.0b013e3181e8fec6.Peer-Reviewed Original ResearchConceptsWhite blood cellsAmniotic fluid white blood cellBlood cell countWBC countAmniotic fluidBloody tapAmniotic fluid white blood cell countCell countAmniotic fluid WBC countRBC/White blood cell countPositive amniotic fluid cultureMaternal WBC countRed blood cell countCells/Number of neutrophilsAbsence of inflammationSetting of inflammationAmniotic fluid culturePositive likelihood ratioAmniotic fluid samplesIntraamniotic inflammationPreterm laborConsecutive womenFluid culture
2008
Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluationNucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
Dulay AT, Buhimschi IA, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg VA, Pettker CM, Thung SF, Bahtiyar MO, Bhandari V, Buhimschi CS. Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. American Journal Of Obstetrics And Gynecology 2008, 198: 426.e1-426.e9. PMID: 18395034, PMCID: PMC4023236, DOI: 10.1016/j.ajog.2008.01.040.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNucleated red blood cellsInflammation-associated preterm birthNRBC countAcid-base statusIntraamniotic inflammationHistological chorioamnionitisNeonatal sepsisRed blood cellsPreterm birthGestational ageCord blood IL-6 levelsBlood IL-6 levelsFetal acid-base statusBlood cellsAbsolute NRBC countsIL-6 levelsEarly neonatal periodIntrauterine growth restrictionHours of birthEarlier gestational ageMediators of inflammationMinutes of deliveryAbsence of hypoxiaPreterm singletonsFetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth
Buhimschi CS, Turan OM, Funai EF, Azpurua H, Bahtiyar MO, Turan S, Zhao G, Dulay A, Bhandari V, Copel JA, Buhimschi IA. Fetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth. Obstetrics And Gynecology 2008, 111: 715-722. PMID: 18310376, DOI: 10.1097/aog.0b013e3181610294.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAdultAmniotic FluidBiomarkersChorioamnionitisDehydroepiandrosterone SulfateFemaleFetal BloodHumansHydrocortisoneInfant, NewbornInfant, PrematureInterleukin-6Organ SizePituitary-Adrenal SystemPregnancyPremature BirthSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationUltrasonography, PrenatalConceptsAdrenal gland volumeFetal adrenal gland volumeIntraamniotic inflammationGland volumeInterleukin-6Preterm birthCord blood IL-6 levelsBlood IL-6 levelsCord blood IL-6Blood IL-6IL-6 levelsCortisol/Dehydroepiandrosterone Sulfate RatioPituitary-adrenocortical systemConsecutive singleton fetusesThree-dimensional ultrasonographyAdrenal volumeFetal adaptationGestational ageSteroid exposureFetal cortisolFetal weightSingleton fetusesUterine contractionsAdrenocortical axisDHEA ratioUsing Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis
Buhimschi IA, Zambrano E, Pettker CM, Bahtiyar MO, Paidas M, Rosenberg VA, Thung S, Salafia CM, Buhimschi CS. Using Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis. Obstetrics And Gynecology 2008, 111: 403-412. PMID: 18238979, DOI: 10.1097/aog.0b013e31816102aa.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersBlack or African AmericanChorioamnionitisFemaleHumansInflammationPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrevalenceProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationWhite PeopleConceptsHistologic chorioamnionitisAmniotic fluidIntra-amniotic inflammationGrade of inflammationAbsence of biomarkersHuman amniotic fluidSurface-enhanced laser desorption ionization timeAfrican American womenPreterm laborSingleton pregnanciesDelivery intervalPlacental pathologyGestational agePremature ruptureSevere inflammationEarly recognitionChorioamnionitisChorionic plateInflammationTherapeutic interventionsProteomic biomarkersCalgranulin CBiomarkersProteomic analysisScoresMultidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth
Buhimschi C, Rosenberg V, Dulay A, Thung S, Sfakianaki A, Bahtiyar M, Buhimschi I. Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth. American Journal Of Perinatology 2008, 25: 175-187. PMID: 18425720, DOI: 10.1055/s-2008-1061497.Peer-Reviewed Original ResearchConceptsPreterm birthSignificant public health problemMost preterm birthsAdverse pregnancy outcomesWeeks of gestationPublic health problemVariety of interventionsNeonatal outcomesPregnancy outcomesDecidual hemorrhagePremature infantsPremature birthLikely multifactorialPathophysiological pathwaysHealth problemsPathophysiological conditionsProteomic biomarkersOxidative stressBirthExcessive stretchingOutcomesHemorrhageGestationInfantsEtiology
2007
The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation
Buhimschi IA, Zhao G, Pettker CM, Bahtiyar MO, Magloire LK, Thung S, Fairchild T, Buhimschi CS. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation. American Journal Of Obstetrics And Gynecology 2007, 196: 181.e1-181.e13. PMID: 17306673, DOI: 10.1016/j.ajog.2006.09.001.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPolymerase chain reactionAF cultureAdvanced glycation end productsAmniotic fluid inflammationThird-trimester controlsEarlier gestational agePlacental villous tissueDegree of inflammationAcute histologic chorioamnionitisNegative AF culturePositive AF cultureExtravillous trophoblast cellsGlycation end productsGestational age dependenceReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHistologic chorioamnionitisIntraamniotic infectionPreterm deliveryInflammatory biomarkersPlacental pathologyGestational ageRAGE systemAcute inflammation