2020
Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers
Tollenaar L, Slaghekke F, Lewi L, Ville Y, Lanna M, Weingertner A, Ryan G, Arévalo S, Khalil A, Brock C, Klaritsch P, Hecher K, Gardener G, Bevilacqua E, Kostyukov K, Bahtiyar M, Kilby M, Tiblad E, Oepkes D, Lopriore E, Middeldorp J, Haak M, Klumper F, Akkermans J, Delagrange H, Pandya V, Faiola S, Favre R, Hobson S, Rodo C, Thilaganathan B, Papanna R, Greimel P, de Sousa M, Carlin A, Gladkova K, Copel J. Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers. Ultrasound In Obstetrics And Gynecology 2020, 56: 378-387. PMID: 32291846, PMCID: PMC7497010, DOI: 10.1002/uog.22042.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequenceFetal therapy centersMonochorionic twin pregnanciesPost-laser twin anemia-polycythemia sequenceExpectant management groupSevere neonatal morbidityIntrauterine transfusionExpectant managementPerinatal mortalitySelective feticideTwin pregnanciesLaser surgeryNeonatal morbidityDelivery groupIUT groupDiagnosis of TAPSMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityBirth intervalLaser surgery groupProlongation of pregnancyTherapy CenterPeak systolic velocityLarge international cohortMedian diagnosis
2019
Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFetal HeartHumansLungLung DiseasesPregnancyRetrospective StudiesSensitivity and SpecificityUltrasonography, PrenatalYoung AdultConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2018
In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence
Bahtiyar MO, Ekmekci E, Demirel E, Irani RA, Copel JA. In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence. Fetal Diagnosis And Therapy 2018, 45: 28-35. PMID: 29533957, DOI: 10.1159/000486198.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequencePlacental vascular connectionsBlood transfusionTwin-twin transfusion syndromePartial exchange transfusionMonochorionic twin pregnanciesVascular connectionsFetoscopic laser photocoagulationLimited outcome dataAbsence of polyhydramniosAnemic twinPlacental territoryTAPS casesDonor twinRecipient twinPlacental sharingTransfusion syndromeChronic anemiaTwin pregnanciesDangerous complicationExchange transfusionPlacental vesselsUnique complicationsLaser photocoagulationPrenatal treatment
2017
Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery
Wilpers AB, Kennedy HP, Wall D, Funk M, Bahtiyar MO. Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery. Journal Of Obstetric Gynecologic & Neonatal Nursing 2017, 46: 456-464. PMID: 28390224, DOI: 10.1016/j.jogn.2017.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersCase-Control StudiesCongenital AbnormalitiesFemaleFetusHumansMaternal AgeMothersNew EnglandPilot ProjectsPregnancyPregnancy OutcomePregnancy Trimester, SecondPregnancy Trimester, ThirdPregnancy, High-RiskPrenatal DiagnosisProspective StudiesReference ValuesRisk AssessmentUltrasonography, PrenatalConceptsNurse care coordinatorsFetal anomaliesMaternal ageMaternal anxietyAnxiety scoresComparison pilot studyOlder maternal ageEarly third trimesterHealth history dataU.S. academic medical centersFetal care centersAcademic medical centerMean state anxiety scoreSpielberger State-Trait Anxiety InventoryMental health issuesState-Trait Anxiety InventoryEmotional supportThird trimesterCare coordinatorsMedical recordsRisk factorsCare centerMedical CenterState anxiety scoresPregnancy
2015
The North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Moise KJ. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 126: 575-584. PMID: 26244534, DOI: 10.1097/aog.0000000000000994.Peer-Reviewed Original ResearchConceptsNorth American Fetal Therapy NetworkBetter patient counselingMonochorionic gestationsRegional treatment centreMonochorionic pregnanciesMultidisciplinary careTimely referralPatient counselingConsensus statementFetal therapyObstetric practitionersFetal disordersTreatment centersTherapy NetworkMedical institutionsManagement optionsNAFTNetComplicationsPregnancyGestationPathophysiologyReferralTherapyScreening for Congenital Heart Disease During Anatomical Survey Ultrasonography
Bahtiyar MO, Copel JA. Screening for Congenital Heart Disease During Anatomical Survey Ultrasonography. Obstetrics And Gynecology Clinics Of North America 2015, 42: 209-223. PMID: 26002162, DOI: 10.1016/j.ogc.2015.01.001.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePrevalence of CHDFetal heart examinationCommon congenital abnormalityPrenatal ultrasound examinationNeonatal outcomesHeart diseaseUltrasound examinationHeart examinationHigh prevalenceLive birthsCongenital abnormalitiesPrevalenceAbnormalitiesDetection rateRegular feedbackTraining programExaminationThe North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 1236-1243. PMID: 25932853, DOI: 10.1097/aog.0000000000000723.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkUnequal placental sharingDetection of complicationsUnique disease processDichorionic gestationsUltrasonographic surveillanceEarly referralPlacental sharingPermanent disabilityConsensus statementPrenatal managementBetter outcomesDisease processClinical practiceGestationSingle placentaTherapy NetworkEarly detectionComplicationsVascular connectionsDeathSurveillanceReferralAngioarchitectureThe North American Fetal Therapy Network Consensus Statement
Bahtiyar MO, Emery SP, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 118-123. PMID: 25560113, DOI: 10.1097/aog.0000000000000599.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkOverall perinatal morbidityUnique disease processBetter patient outcomesDisproportionate disease burdenPerinatal morbidityPregnancy complicationsPrompt referralRegional treatment centreMultidisciplinary careCommon placentaDisease burdenPatient outcomesComprehensive counselingConsensus statementFetal disordersFetal surgeryDisease processTreatment centersTherapy NetworkGestationEarly detectionComplicationsMedical institutions
2011
Assessment of the fetal thymus by two‐ and three‐dimensional ultrasound during normal human gestation and in fetuses with congenital heart defects
Li L, Bahtiyar M, Buhimschi C, Zou L, Zhou Q, Copel J. Assessment of the fetal thymus by two‐ and three‐dimensional ultrasound during normal human gestation and in fetuses with congenital heart defects. Ultrasound In Obstetrics And Gynecology 2011, 37: 404-409. PMID: 20886509, DOI: 10.1002/uog.8853.Peer-Reviewed Original Research
2010
Is the Rate of Congenital Heart Defects Detected by Fetal Echocardiography Among Pregnancies Conceived by In Vitro Fertilization Really Increased?
Bahtiyar MO, Campbell K, Dulay AT, Kontic-Vucinic O, Weeks BP, Friedman AH, Copel JA. Is the Rate of Congenital Heart Defects Detected by Fetal Echocardiography Among Pregnancies Conceived by In Vitro Fertilization Really Increased? Journal Of Ultrasound In Medicine 2010, 29: 917-922. PMID: 20498466, DOI: 10.7863/jum.2010.29.6.917.Peer-Reviewed Original ResearchConceptsIVF pregnanciesFrequency of CHDsFetal echocardiographyCHD riskGeneral populationCongenital heartContemporary general populationIVF twin pregnanciesHigher-order pregnanciesIntracytoplasmic sperm injectionFertilization pregnanciesStudy patientsTwin gestationsTwin pregnanciesPrenatal prevalencePopulation dataStudy populationHigh riskSperm injectionPregnancyVitro FertilizationEchocardiographyReferral programCHDPatientsAcceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity
Azpurua H, Norwitz ER, Campbell KH, Funai EF, Pettker CM, Kleine M, Bahtiyar MO, Malkus H, Copel JA, Thung SF. Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity. American Journal Of Obstetrics And Gynecology 2010, 203: 40.e1-40.e8. PMID: 20417479, DOI: 10.1016/j.ajog.2010.01.075.Peer-Reviewed Original ResearchConceptsAcceleration time/ejection time ratioEjection time ratioFetal lung maturityLecithin/sphingomyelin ratioFetal pulmonary arteryLung maturitySphingomyelin ratioPulmonary arteryAcceleration/ejection time ratioPulmonary artery blood flowSystolic/diastolic ratioYale-New Haven HospitalAmniotic fluid biomarkersAmniotic fluid lecithin/sphingomyelin ratioArtery blood flowFlow velocity waveformsFlow velocity parametersNew noninvasive techniqueSingleton pregnanciesDiastolic ratioPulsatility indexUltrasound evaluationFluid biomarkersPotential confoundersStudy criteria
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimesterFetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth
Buhimschi CS, Turan OM, Funai EF, Azpurua H, Bahtiyar MO, Turan S, Zhao G, Dulay A, Bhandari V, Copel JA, Buhimschi IA. Fetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth. Obstetrics And Gynecology 2008, 111: 715-722. PMID: 18310376, DOI: 10.1097/aog.0b013e3181610294.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAdultAmniotic FluidBiomarkersChorioamnionitisDehydroepiandrosterone SulfateFemaleFetal BloodHumansHydrocortisoneInfant, NewbornInfant, PrematureInterleukin-6Organ SizePituitary-Adrenal SystemPregnancyPremature BirthSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationUltrasonography, PrenatalConceptsAdrenal gland volumeFetal adrenal gland volumeIntraamniotic inflammationGland volumeInterleukin-6Preterm birthCord blood IL-6 levelsBlood IL-6 levelsCord blood IL-6Blood IL-6IL-6 levelsCortisol/Dehydroepiandrosterone Sulfate RatioPituitary-adrenocortical systemConsecutive singleton fetusesThree-dimensional ultrasonographyAdrenal volumeFetal adaptationGestational ageSteroid exposureFetal cortisolFetal weightSingleton fetusesUterine contractionsAdrenocortical axisDHEA ratio