Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers
Tollenaar L, Slaghekke F, Lewi L, Ville Y, Lanna M, Weingertner A, Ryan G, Arévalo S, Khalil A, Brock C, Klaritsch P, Hecher K, Gardener G, Bevilacqua E, Kostyukov K, Bahtiyar M, Kilby M, Tiblad E, Oepkes D, Lopriore E, Middeldorp J, Haak M, Klumper F, Akkermans J, Delagrange H, Pandya V, Faiola S, Favre R, Hobson S, Rodo C, Thilaganathan B, Papanna R, Greimel P, de Sousa M, Carlin A, Gladkova K, Copel J. Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers. Ultrasound In Obstetrics And Gynecology 2020, 56: 378-387. PMID: 32291846, PMCID: PMC7497010, DOI: 10.1002/uog.22042.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequenceFetal therapy centersMonochorionic twin pregnanciesPost-laser twin anemia-polycythemia sequenceExpectant management groupSevere neonatal morbidityIntrauterine transfusionExpectant managementPerinatal mortalitySelective feticideTwin pregnanciesLaser surgeryNeonatal morbidityDelivery groupIUT groupDiagnosis of TAPSMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityBirth intervalLaser surgery groupProlongation of pregnancyTherapy CenterPeak systolic velocityLarge international cohortMedian diagnosisPost-Laser Twin Anemia Polycythemia Sequence: Diagnosis, Management, and Outcome in an International Cohort of 164 Cases
Tollenaar LSA, Lopriore E, Faiola S, Lanna M, Stirnemann J, Ville Y, Lewi L, Devlieger R, Weingertner AS, Favre R, Hobson SR, Ryan G, Rodo C, Arévalo S, Klaritsch P, Greimel P, Hecher K, de Sousa MT, Khalil A, Thilaganathan B, Bergh EP, Papanna R, Gardener GJ, Carlin A, Bevilacqua E, Sakalo VA, Kostyukov KV, Bahtiyar MO, Wilpers A, Kilby MD, Tiblad E, Oepkes D, Middeldorp JM, Haak MC, Klumper FJCM, Akkermans J, Slaghekke F. Post-Laser Twin Anemia Polycythemia Sequence: Diagnosis, Management, and Outcome in an International Cohort of 164 Cases. Journal Of Clinical Medicine 2020, 9: 1759. PMID: 32517071, PMCID: PMC7355738, DOI: 10.3390/jcm9061759.Peer-Reviewed Original ResearchTwin anemia-polycythemia sequenceSevere neonatal morbidityPost-laser twin anemia-polycythemia sequenceNeonatal morbidityGestational agePerinatal mortalityPartial exchange transfusionIndependent risk factorMedian gestational agePerinatal mortality rateRisk factor analysisTermination of pregnancyDonor twinExpectant managementInitial surgeryIntrauterine transfusionPerinatal outcomesAntenatal managementSecondary outcomesPrimary outcomeExchange transfusionOptimal treatmentRisk factorsMedian numberInternational cohort