2021
Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis
Sehrawat T, Arab J, Liu M, Amrollahi P, Wan M, Fan J, Nakao Y, Pose E, Navarro‐Corcuera A, Dasgupta D, Liao C, He L, Mauer A, Avitabile E, Ventura‐Cots M, Bataller R, Sanyal A, Chalasani N, Heimbach J, Watt K, Gores G, Gines P, Kamath P, Simonetto D, Hu T, Shah V, Malhi H. Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis. Hepatology 2021, 73: 571-585. PMID: 32246544, PMCID: PMC7541595, DOI: 10.1002/hep.31256.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseAlcohol-associated cirrhosisAlcoholic hepatitisAH subjectsHealthy controlsHeavy drinkersLiver diseaseEtiology of ESLDEV concentrationEnd-stage liver disease (MELD) scoreExtracellular vesiclesRisk profilingPathogenesis of AHLiver Disease scoreCholestatic liver diseaseNonalcoholic steatohepatitisRisk stratificationClinical criteriaPrognostic performanceDisease scoreDiagnostic biomarkersDisease controlEV countsDiseaseDrinkers
2020
Hyperammonemic Encephalopathy Exacerbated by Parenteral Nutrition in Fibrolamellar Hepatocellular Carcinoma
Shah P, Cho J, Albitar H, Pajot G, Liu M, Ravi K. Hyperammonemic Encephalopathy Exacerbated by Parenteral Nutrition in Fibrolamellar Hepatocellular Carcinoma. The American Journal Of Medicine 2020, 133: e745-e746. PMID: 32739410, DOI: 10.1016/j.amjmed.2020.06.022.Peer-Reviewed Original Research
2014
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
Bonsignori M, Wiehe K, Grimm S, Lynch R, Yang G, Kozink D, Perrin F, Cooper A, Hwang K, Chen X, Liu M, McKee K, Parks R, Eudailey J, Wang M, Clowse M, Criscione-Schreiber L, Moody M, Ackerman M, Boyd S, Gao F, Kelsoe G, Verkoczy L, Tomaras G, Liao H, Kepler T, Montefiori D, Mascola J, Haynes B. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. Journal Of Clinical Investigation 2014, 124: 1835-1843. PMID: 24614107, PMCID: PMC3973118, DOI: 10.1172/jci73441.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceAntibodies, AntinuclearAntibodies, NeutralizingAutoantibodiesBase SequenceB-LymphocytesDNAFemaleHIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHIV-1HumansImmunologic MemoryLupus Erythematosus, SystemicModels, MolecularMolecular Sequence DataMultiprotein ComplexesMutationProtein ConformationSequence Homology, Amino AcidSequence Homology, Nucleic AcidViral LoadConceptsHIV-1-infected individualsAnti-dsDNA reactivityHeavy chain complementarity-determining region 3Autoimmune diseasesB cellsHIV-1 envelope glycoprotein 120HIV-1-neutralizing antibodiesImmune tolerance mechanismsMemory B cellsEnvelope glycoprotein 120CD4 binding siteComplementarity-determining region 3Somatic mutationsCD4bs bnAbsHLA phenotypesViral loadAutoreactive antibodiesBnAb developmentChain complementarity-determining region 3Neutralization breadthGlycoprotein 120HIV-1Patient plasmaHuman antigensBnAbs