Polyreactivity and Autoreactivity among HIV-1 Antibodies
Liu M, Yang G, Wiehe K, Nicely N, Vandergrift N, Rountree W, Bonsignori M, Alam S, Gao J, Haynes B, Kelsoe G. Polyreactivity and Autoreactivity among HIV-1 Antibodies. Journal Of Virology 2014, 89: 784-798. PMID: 25355869, PMCID: PMC4301171, DOI: 10.1128/jvi.02378-14.Peer-Reviewed Original ResearchConceptsNeutralization breadthMembrane-proximal external regionMultiple HIV-1 cladesCD4 T-cell depletionChronic antigen exposureHIV-1 AbT-cell depletionHIV-1 infectionHIV-1 vaccineHIV-1 antibodiesHIV-1 cladesHIV-1 CD4HIV-1 envelopeHIV-1 neutralizationAntigen exposureChronic inflammationHumoral responseInfected patientsProtective vaccineImmune regulationHIV-1AutoreactivityAutoreactive propertiesAg exposureHost AgAn autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
Bonsignori M, Wiehe K, Grimm S, Lynch R, Yang G, Kozink D, Perrin F, Cooper A, Hwang K, Chen X, Liu M, McKee K, Parks R, Eudailey J, Wang M, Clowse M, Criscione-Schreiber L, Moody M, Ackerman M, Boyd S, Gao F, Kelsoe G, Verkoczy L, Tomaras G, Liao H, Kepler T, Montefiori D, Mascola J, Haynes B. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. Journal Of Clinical Investigation 2014, 124: 1835-1843. PMID: 24614107, PMCID: PMC3973118, DOI: 10.1172/jci73441.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceAntibodies, AntinuclearAntibodies, NeutralizingAutoantibodiesBase SequenceB-LymphocytesDNAFemaleHIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHIV-1HumansImmunologic MemoryLupus Erythematosus, SystemicModels, MolecularMolecular Sequence DataMultiprotein ComplexesMutationProtein ConformationSequence Homology, Amino AcidSequence Homology, Nucleic AcidViral LoadConceptsHIV-1-infected individualsAnti-dsDNA reactivityHeavy chain complementarity-determining region 3Autoimmune diseasesB cellsHIV-1 envelope glycoprotein 120HIV-1-neutralizing antibodiesImmune tolerance mechanismsMemory B cellsEnvelope glycoprotein 120CD4 binding siteComplementarity-determining region 3Somatic mutationsCD4bs bnAbsHLA phenotypesViral loadAutoreactive antibodiesBnAb developmentChain complementarity-determining region 3Neutralization breadthGlycoprotein 120HIV-1Patient plasmaHuman antigensBnAbs