2024
Promoting Race and Ethnic Diversity in a Hospital-Based Randomized Clinical Trial to Address Untreated Alcohol Use Disorder: Initial Lessons Learned.
Edelman E, Frankforter T, Rojas-Perez O, Ablondi K, Castro C, Corvino J, Garcia I, Gordon D, Jaramillo Y, Johnson N, Jordan A, Nich C, Paris M, Pagano D, Weimer M, Williams E, Kiluk B. Promoting Race and Ethnic Diversity in a Hospital-Based Randomized Clinical Trial to Address Untreated Alcohol Use Disorder: Initial Lessons Learned. Journal Of Addiction Medicine 2024 PMID: 39514895, DOI: 10.1097/adm.0000000000001400.Peer-Reviewed Original ResearchAlcohol use disorderBrief Negotiation InterviewUntreated alcohol use disorderUse disorderSocial determinants of healthCognitive behavioral therapyElectronic medical record dataDeterminants of healthEthnically diverse sampleMedical record dataMonths of recruitmentBehavioral therapyModifications-EnhancedReporting AdaptationsTreatment engagementEffectiveness of strategiesSocial determinantsInitiation of medicationRecruitment approachesDiverse samplePost-hospitalizationAlcohol useResearch staffParent trialRecord dataBuprenorphine for Opioid Use Disorder—An Essential Medical Treatment
Weimer M, Morford K. Buprenorphine for Opioid Use Disorder—An Essential Medical Treatment. JAMA Internal Medicine 2024, 184: 1248-1249. PMID: 39186298, DOI: 10.1001/jamainternmed.2024.3977.Peer-Reviewed Original ResearchDevelopment of a Patient and Clinician Informed Website on Injection Drug Use Related Infective Endocarditis.
Chan C, Minahan-Rowley R, Biegacki E, Sue K, Weimer M. Development of a Patient and Clinician Informed Website on Injection Drug Use Related Infective Endocarditis. Substance Use & Addiction Journal 2024, 29767342241267077. PMID: 39087514, DOI: 10.1177/29767342241267077.Peer-Reviewed Original ResearchInjection drug use-related infective endocarditisSemi-structured interviewsInjection drug usePatient participationPatient websitesInjection practicesInfective endocarditisPatient education resourcesHelpfulness of informationHistory of injection drug useDrug useMixed-methods studyHealthcare cliniciansBaseline surveyOpioid use disorderPrevention strategiesInformation websitesEducational materialsCounseling patientsHospitalized adultsPromote educationWebsite sectionsCliniciansSurvey feedbackUse disorderTreatment of alcohol use disorder in patients with liver disease
Hill G, Cohen S, Weimer M. Treatment of alcohol use disorder in patients with liver disease. Clinical Liver Disease 2024, 23: e0217. PMID: 38841192, PMCID: PMC11152780, DOI: 10.1097/cld.0000000000000217.Peer-Reviewed Original ResearchThe American Society of Addiction Medicine Clinical Practice Guideline Development Methodology
Weimer M, Devoto A, Kansagara D, Safarian T, Brunner E, Stock A, Rastegar D, Nelson L, Tirado C, Korthuis P, Boyle M. The American Society of Addiction Medicine Clinical Practice Guideline Development Methodology. Journal Of Addiction Medicine 2024, 18: 366-372. PMID: 38752709, DOI: 10.1097/adm.0000000000001312.Peer-Reviewed Original ResearchClinical practice guidelinesClinical practice guidelines methodologyPromote evidence-based best practicesEvidence-based best practicesPublished clinical practice guidelinesGuideline development methodologyAmerican Society of Addiction Medicine (ASAMOrganizational prioritiesPractice guidelinesAddiction preventionAmerican SocietyBest practicesNational HIV and HCV Screening Rates for Hospitalized People who Use Drugs Are Suboptimal and Heterogeneous Across 11 US Hospitals
Westgard L, Sato T, Bradford W, Eaton E, Pilcher F, Hale A, Singh D, Martin M, Appa A, Meyer J, Weimer M, Barakat L, Felsen U, Akiyama M, Ridgway J, Grussing E, Thakarar K, White A, Mutelayi J, Krsak M, Montague B, Nijhawan A, Balakrishnan H, Marks L, Wurcel A. National HIV and HCV Screening Rates for Hospitalized People who Use Drugs Are Suboptimal and Heterogeneous Across 11 US Hospitals. Open Forum Infectious Diseases 2024, 11: ofae204. PMID: 38746950, PMCID: PMC11093397, DOI: 10.1093/ofid/ofae204.Peer-Reviewed Original ResearchScreening ratesHepatitis C virusTesting ratesHepatitis C virus screening ratesHIV screening ratesHIV testing ratesOpt-out testing policyHCV screening ratesStatistically significant differenceHepatitis C virus antibody testingInjection drug useAssociated with statistically significant differencesViral load testingNational HIVHospital sitesHCV antibody testingInpatient encountersUS hospitalsSignificant differenceInpatient hospitalizationU.S. hospitalsInpatient testingPWUDHospitalized peopleHospital
2023
Long-Term Treatment of Opioid Use Disorder with Medications
Wolfgang A, Weimer M, Na P, Fiellin D, Muvvala S. Long-Term Treatment of Opioid Use Disorder with Medications. 2023, 631-661. DOI: 10.1093/oxfordhb/9780197618431.013.23.ChaptersOpioid use disorderMedical diseasesUse disordersChronic medical diseasesExtended-release naltrexoneLong-term treatmentCause mortalityOUD treatmentClinical outcomesOngoing treatmentOpioid overdoseTerm treatmentMedicationsPsychosocial outcomesAddiction treatmentDisease paradigmOutcomesTreatmentEvidence-based paradigmDiseaseDisordersNegative outcomesImproved retentionRemissionRelapsingASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids
Weimer M, Herring A, Kawasaki S, Meyer M, Kleykamp B, Ramsey K. ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids. Journal Of Addiction Medicine 2023, 17: 632-639. PMID: 37934520, DOI: 10.1097/adm.0000000000001202.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh potency synthetic opioidsOpioid use disorderBuprenorphine initiationBuprenorphine treatmentTreatment needsUse disordersClinical considerationsExpert consensusSynthetic opioidsTreatment of OUDProspective researchOpioid agonist treatmentLong-term treatmentDrug supplyPatients' treatment needsOpioid withdrawalBuprenorphine doseOUD treatmentAgonist treatmentDosing frequencyClinical questionsFrontline cliniciansClinical practiceTreatment settingsIndividualized strategiesResponse to substance use during hospitalization: A survey study of current and ideal policies and practices
Huxley‐Reicher Z, Puglisi L, Tetrault J, Weimer M, Stellini M, Bhandary‐Alexander J, Thomas K, Donroe J. Response to substance use during hospitalization: A survey study of current and ideal policies and practices. Journal Of Hospital Medicine 2023, 18: 829-834. PMID: 37475186, DOI: 10.1002/jhm.13162.Peer-Reviewed Original ResearchHospital policiesAddiction medicine fellowshipsPatient-directed dischargeSubstance useCross-sectional studyWorse patient outcomesMajority of hospitalsAcute hospitalizationPatient outcomesUse of substancesPatient-centered policiesHospitalizationUS hospitalsLittle dataGraduate Medical EducationHospitalCliniciansAccreditation CouncilSurvey studyResponseCurrent practiceRevisiting Ethical Considerations in Recurrent Injection Drug Use–Related Infective Endocarditis
Hull S, Jadbabaie F, Weimer M, Golden M, Vallabhajosyula P, Rosenfeld L. Revisiting Ethical Considerations in Recurrent Injection Drug Use–Related Infective Endocarditis. Annals Of Thoracic Surgery Short Reports 2023, 1: 369-371. DOI: 10.1016/j.atssr.2023.02.025.Commentaries, Editorials and LettersBetter care at the bedside for hospitalized patients with opioid use disorder
Calcaterra S, Buresh M, Weimer M. Better care at the bedside for hospitalized patients with opioid use disorder. Journal Of Hospital Medicine 2023, 18: 1134-1138. PMID: 37016586, PMCID: PMC10548352, DOI: 10.1002/jhm.13099.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLow-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series
Adams K, Cohen S, Guerra M, Weimer M. Low-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series. Journal Of Addiction Medicine 2023, 17: 474-476. PMID: 37579114, DOI: 10.1097/adm.0000000000001146.Peer-Reviewed Original ResearchConceptsOpioid use disorderBuprenorphine initiationSublingual buprenorphineChronic painBuccal buprenorphineCase seriesClinical Opiate Withdrawal Scale (COWS) scoresAddiction medicine serviceLow dose initiationSevere opioid withdrawalHistory of heroinOutpatient opioidsOpioid withdrawalAcute painFentanyl useHospitalized patientsMedian lengthPrescription refillsMedian numberModerate withdrawalInitiation strategiesBuprenorphineMedicine servicePatientsUse disordersPrecipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report
Christian N, Butner J, Evarts M, Weimer M. Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report. Journal Of Addiction Medicine 2023, 17: 488-490. PMID: 37579118, DOI: 10.1097/adm.0000000000001151.Peer-Reviewed Case Reports and Technical NotesConceptsClinical Opiate Withdrawal Scale (COWS) scoresOpioid use disorderKetamine infusionOpioid withdrawalCase reportUse disordersScale scoreSevere opioid use disorderFull opioid agonistsHours of admissionEmergency department settingFirst case reportInpatient hospital settingLife-saving medicationsReceptor-mediated signalingLack of evidenceMale patientsFentanyl useOpioid agonistsEmergency departmentComplete resolutionDepartment settingClinical dilemmaAppropriate treatmentHospital settingMultidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation
Rosenfeld L, Jain S, Amabile A, Geirsson A, Krane M, Weimer M. Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. Journal Of Clinical Medicine 2023, 12: 882. PMID: 36769531, PMCID: PMC9917424, DOI: 10.3390/jcm12030882.Peer-Reviewed Original ResearchCardiac arrestVentricular fibrillationOpioid useGroup IMOUD useInfective endocarditisYale-New Haven HospitalGroup II patientsCardiac surgeryMultidisciplinary managementQTc prolongationII patientsCS patientsInjection useOpioid epidemicHistorical groupLong-term effectsDisorder treatmentPatientsQTc measurementsQTcHospitalizationEndocarditisSurgeryArrestPromoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2022
Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine
Neale KJ, Weimer MB, Davis MP, Jones KF, Kullgren JG, Kale SS, Childers J, Broglio K, Merlin JS, Peck S, Francis SY, Bango J, Jones CA, Sager Z, Ho JJ. Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine. Journal Of Palliative Medicine 2022, 26: 120-130. PMID: 36067137, DOI: 10.1089/jpm.2022.0399.Commentaries, Editorials and LettersConceptsPalliative carePain managementPartial mu-opioid receptor agonistSerious illnessMu-opioid receptor agonistTop Ten TipsOpioid use disorderLife-limiting illnessPC cliniciansCare cliniciansOpioid misuseBuprenorphine useReceptor agonistNurse practitionersUse disordersPopulation-wide trendsIllnessBuprenorphineCliniciansPatientsAgonistsPharmacistsPhysiciansCareSocial workersManagement of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement From the American Heart Association
Baddour LM, Weimer MB, Wurcel AG, McElhinney DB, Marks LR, Fanucchi LC, Garrigos Z, Pettersson GB, DeSimone DC, Fever E. Management of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement From the American Heart Association. Circulation 2022, 146: e187-e201. PMID: 36043414, DOI: 10.1161/cir.0000000000001090.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Heart AssociationInfective endocarditisHeart AssociationScientific statementInjection drug useAspects of careInfective endocarditis casesEnglish-language articlesRemoval of duplicatesEndocarditis teamVariety of specialistsEndocarditis casesCardiovascular surgeryIncreasing incidenceSubsequent boutEndocarditisHigh riskInitial boutDrug useInfectious diseasesAddiction medicineLiterature searchPreventive measuresUnique populationDrugsManagement of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine
Calcaterra SL, Martin M, Bottner R, Englander H, Weinstein Z, Weimer MB, Lambert E, Herzig SJ. Management of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine. Journal Of Hospital Medicine 2022, 17: 744-756. PMID: 35880813, PMCID: PMC9474708, DOI: 10.1002/jhm.12893.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid use disorderConsensus statementHospitalized adultsOpioid withdrawalUse disordersTreatment of OUDDraft statementManagement of OUDHospital medicineAcute pain managementNumber of hospitalizationsHospital-based cliniciansFinal consensus statementOpioid-related overdoseHospital dischargeOpioid usePain managementWorking GroupCare transitionsInpatient settingObservational studyExpert consensusGuidance statementsPatientsSystematic reviewManagement of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines
Calcaterra SL, Bottner R, Martin M, Englander H, Weinstein ZM, Weimer MB, Lambert E, Ronan MV, Huerta S, Zaman T, Ullal M, Peterkin AF, Torres‐Lockhart K, Buresh M, O'Brien MT, Snyder H, Herzig SJ. Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines. Journal Of Hospital Medicine 2022, 17: 679-692. PMID: 35880821, PMCID: PMC9474657, DOI: 10.1002/jhm.12908.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid overdose preventionOpioid withdrawalOpioid useOUD treatmentOverdose preventionShort-acting opioid analgesicsOpioid use disorder managementAcute pain managementUse of methadoneOpioid use disorderEvaluation II (AGREE II) instrumentAppraisal of GuidelinesOpioid withdrawal managementUse of multimodalOpioid overdose reversalMethadone initiationNonopioid therapyHospitalized adultsBuprenorphine treatmentOpioid analgesicsPain managementTreatment guidelinesDiagnostic Statistical ManualOvid MEDLINEEdition criteriaThe X Waiver to Prescribe Buprenorphine: The Why and How
Jones K, Ho JJ, Merlin JS, Weimer M, Sager Z, Kapo J, Childers J. The X Waiver to Prescribe Buprenorphine: The Why and How. Journal Of Palliative Medicine 2022, 25: 1021-1023. PMID: 35775892, DOI: 10.1089/jpm.2022.0170.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements