2024
Feeding critically ill patients at the right time of day
Dashti H, Wang Y, Knauert M. Feeding critically ill patients at the right time of day. Critical Care 2024, 28: 206. PMID: 38915028, PMCID: PMC11197374, DOI: 10.1186/s13054-024-04994-0.Peer-Reviewed Original ResearchEarly goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-hospital deathCritically ill adultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcome
2019
Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes
Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCircadian RhythmCritical CareCritical IllnessHumansIntensive Care UnitsSleepSleep Wake DisordersConceptsIll patientsIntensive care unit careIntensive care unit practiceCircadian rhythmCurrent ICU practiceLow-risk interventionNumerous adverse outcomesUnit careCritical illnessImmune compromiseCardiovascular instabilityMetabolic derangementsAdverse outcomesICU practiceUnit practicesSleep disruptionCare improvementPatientsOutcomesSleepRhythmBright lightDaysCircadian biologyDeliriumPilot study: an intensive care unit sleep promotion protocol
Knauert MP, Pisani M, Redeker N, Murphy T, Araujo K, Jeon S, Yaggi H. Pilot study: an intensive care unit sleep promotion protocol. BMJ Open Respiratory Research 2019, 6: e000411. PMID: 31258916, PMCID: PMC6561389, DOI: 10.1136/bmjresp-2019-000411.Peer-Reviewed Original ResearchConceptsPromotion protocolProtocol armUsual careSleep protocolICU sleepProtocol patientsIll patientsPrimary outcomeSleep disruptionBedside careRoom entryPatientsRoom activitiesSleep opportunityCareLength of timeProtocol effectMean ARoom disturbancesGeneralised linear modelArmTime blocksEquivalent levelsRoom entranceActivity
2018
Non-circadian signals in the intensive care unit: Point prevalence morning, noon and night
Altman MT, Pulaski C, Mburu F, Pisani MA, Knauert MP. Non-circadian signals in the intensive care unit: Point prevalence morning, noon and night. Heart & Lung 2018, 47: 610-615. PMID: 30143362, PMCID: PMC6234066, DOI: 10.1016/j.hrtlng.2018.07.011.Peer-Reviewed Original ResearchMeSH KeywordsCircadian RhythmCritical CareHumansIntensive Care UnitsLightNoiseRespiration, ArtificialSleepSleep Wake DisordersSurveys and QuestionnairesTime FactorsConceptsSleep promotion interventionsIntensive care unitICU patient roomsQuality improvement initiativesCare unitSleep disturbancesObservational studyICU roomAbnormal lightPatient roomsSound exposureImprovement initiativesDoor curtainsInterventionPrevalenceEnvironmental factorsBright lightRoom doorICUFactors
2017
Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff.
Ding Q, Redeker NS, Pisani MA, Yaggi HK, Knauert MP. Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff. American Journal Of Critical Care 2017, 26: 278-286. PMID: 28668912, PMCID: PMC5559223, DOI: 10.4037/ajcc2017333.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitPatients' sleepCare unitSleep improvementIntensive care unit staffIntensive care unit environmentPerceptions of patientsAdequate sleep opportunityIll patientsBeliefs of staffClinical outcomesSleep qualityRestorative sleepUnit staffPatientsClinical staffPatient surrogatesSleepUnit environmentSleep opportunityOnly factorPatients' emotionsNonenvironmental factorsSemistructured interviewsSleep Disturbance after Hospitalization and Critical Illness: A Systematic Review
Altman MT, Knauert MP, Pisani MA. Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review. Annals Of The American Thoracic Society 2017, 14: 1457-1468. PMID: 28644698, PMCID: PMC5711402, DOI: 10.1513/annalsats.201702-148sr.BooksConceptsCritical illnessHospital dischargeSleep disturbancesRisk factorsSystematic reviewIntensive care unit admissionCare unit admissionIll adult patientsTime pointsCritical illness survivorsObjective sleep parametersQuestionnaire studyUnit admissionAdult patientsHospital factorsIll patientsPrimary outcomePrehospital factorsImpaired qualityObjective measurement toolsPsychological comorbiditiesAbnormal sleepMultiple time pointsPolysomnography studiesPoor sleep
2016
Reply: Sleep in the Intensive Care Unit Is a Priority
Knauert MP, Kamdar BB. Reply: Sleep in the Intensive Care Unit Is a Priority. Annals Of The American Thoracic Society 2016, 13: 1868-1869. PMID: 27726437, PMCID: PMC5122496, DOI: 10.1513/annalsats.201607-578le.Commentaries, Editorials and LettersPerceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers
Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.Peer-Reviewed Original ResearchConceptsPoor sleepICU outcomesProviders' perceptionsIntensive care unit outcomesAvailable evidence-based guidelinesDevelopment of deliriumIntensive care unitEvidence-based guidelinesCritical care providersBetter sleep qualityMinority of providersICU surveyICU patientsIll patientsCare unitMechanical ventilationICU providersPatient outcomesRecent guidelinesPhysical therapyMost cliniciansPromotion protocolSleep qualityCare providersICUComparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales
Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.Peer-Reviewed Original ResearchMeSH KeywordsCritical CareFacility Design and ConstructionFemaleHumansIntensive Care UnitsMaleMiddle AgedNoisePatients' RoomsProspective StudiesConceptsIntensive care unitMedical intensive care unitCare unitWorld Health Organization recommendationsProspective observational studyICU patient roomsIllness severityPatient factorsMechanical ventilationObservational studyPeak occurrenceICU environmentSignificant discordanceCircadian disruptionPatient roomsDecibel scaleSound levelsEquivalent sound levelPeak measuresDeliriumLevelsMeaningful factorsSleepLow-frequency soundAverage level
2015
Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit
Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.BooksMeSH KeywordsCircadian RhythmCritical IllnessDeliriumHumansIntensive Care UnitsSleepSleep DeprivationConceptsCritical illnessSleep disruptionAppropriate administrative supportIntensive care unit environmentIntensive care unitCircadian rhythm disruptionDelirium reductionIll patientsCare unitPharmacologic interventionsSleep disturbancesRhythm disruptionCare deliveryMultidisciplinary strategyUnit environmentSleep lossIllnessDisruptionPatientsEffective strategySleepEnvironmental factors
2014
Feasibility study of unattended polysomnography in medical intensive care unit patients
Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArousalElectroencephalographyFeasibility StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedPilot ProjectsPolysomnographySleepConceptsMedical intensive care unitPortable polysomnographySleep efficiencyMedical intensive care unit patientsIntensive care unit patientsSleep deprivationOvernight sleep durationCare unit patientsObservational pilot studyIntensive care unitIndicators of feasibilityUnattended polysomnographyUnit patientsIll patientsPatients' sleepCare unitArousal indexPSG studiesSleep durationPatientsInterpretable qualityPilot studyGold standardSleepSleep stages