2018
Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin
Murphy TF, Brauer AL, Pettigrew MM, LaFontaine ER, Tettelin H. Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin. The Journal Of Infectious Diseases 2018, 219: 1448-1455. PMID: 30496439, PMCID: PMC6467191, DOI: 10.1093/infdis/jiy680.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseM. catarrhalisPulmonary diseaseMoraxella catarrhalisPersistent strainsDuration of persistenceHuman airwaysCatarrhalisCessation of expressionAirwayMajor pathogenPatientsBacterial pathogensDiseaseVirulence-associated phenotypesAdultsCollected strainsMost strainsExpressionHuman cellsPathogensPathogenesisPersistenceMonths
2012
Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media
Ruohola A, Pettigrew MM, Lindholm L, Jalava J, Räisänen KS, Vainionpää R, Waris M, Tähtinen PA, Laine MK, Lahti E, Ruuskanen O, Huovinen P. Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media. Journal Of Infection 2012, 66: 247-254. PMID: 23266462, PMCID: PMC3571106, DOI: 10.1016/j.jinf.2012.12.002.Peer-Reviewed Original ResearchConceptsRisk of AOMAcute otitis mediaMiddle ear effusionAOM groupRespiratory virusesAOM pathogensAcute symptomsOtitis mediaEar effusionM. catarrhalisAcute inflammatory signsNasopharyngeal bacterial colonizationRespiratory tract infectionsOtoscopic signsTract infectionsInflammatory signsNasopharyngeal samplesSymptomatic childrenNasopharyngeal bacteriaH. influenzaePneumatic otoscopyS. pneumoniaeViral interactionsBacterial colonizationEffusionUpper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children
Pettigrew MM, Laufer AS, Gent JF, Kong Y, Fennie KP, Metlay JP. Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children. Applied And Environmental Microbiology 2012, 78: 6262-6270. PMID: 22752171, PMCID: PMC3416608, DOI: 10.1128/aem.01051-12.Peer-Reviewed Original ResearchConceptsAcute otitis mediaAntibiotic useS. pneumoniaeHealthy childrenM. catarrhalisH. influenzaeAcute otitis media pathogensConcurrent acute otitis mediaUpper respiratory tract infectionRespiratory tract infectionsOtitis media pathogensUpper respiratory tractCross-sectional studyYears of ageAOM pathogensTract infectionsOtitis mediaMoraxella catarrhalisRespiratory tractReal-time PCRNasal swabsSick childrenPrevention strategiesHaemophilus influenzaeStreptococcus pneumoniae
2008
Microbial Interactions during Upper Respiratory Tract Infections - Volume 14, Number 10—October 2008 - Emerging Infectious Diseases journal - CDC
Pettigrew MM, Gent JF, Revai K, Patel JA, Chonmaitree T. Microbial Interactions during Upper Respiratory Tract Infections - Volume 14, Number 10—October 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1584-1591. PMID: 18826823, PMCID: PMC2609881, DOI: 10.3201/eid1410.080119.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCohort StudiesFemaleHaemophilus InfectionsHaemophilus influenzaeHumansInfantMaleMoraxella catarrhalisMoraxellaceae InfectionsNasopharynxOtitis MediaProspective StudiesRespiratory Tract InfectionsStaphylococcal InfectionsStaphylococcus aureusStreptococcus pneumoniaeSuperinfectionConceptsUpper respiratory tract infectionH. influenzaeInfectious Diseases journal - CDCRespiratory tract infectionsS. pneumoniae colonizationHealthy children 6Months of ageS. aureusProspective cohortTract infectionsPneumoniae colonizationVaccination strategiesAntimicrobial therapyMoraxella catarrhalisChildren 6M. catarrhalisS. pneumoniaeHaemophilus influenzaeStreptococcus pneumoniaeBacterial infectionsSpecific bacterial speciesInfluenzaeLikelihood of colonizationCatarrhalisStaphylococcus aureus