2023
International Consensus Statement on Obstructive Sleep Apnea
Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera J, Bartley B, Billings M, Boon M, Bosschieter P, Braverman I, Brodie K, Cabrera‐Muffly C, Caesar R, Cahali M, Cai Y, Cao M, Capasso R, Caples S, Chahine L, Chang C, Chang K, Chaudhary N, Cheong C, Chowdhuri S, Cistulli P, Claman D, Collen J, Coughlin K, Creamer J, Davis E, Dupuy‐McCauley K, Durr M, Dutt M, Ali M, Elkassabany N, Epstein L, Fiala J, Freedman N, Gill K, Gillespie M, Golisch L, Gooneratne N, Gottlieb D, Green K, Gulati A, Gurubhagavatula I, Hayward N, Hoff P, Hoffmann O, Holfinger S, Hsia J, Huntley C, Huoh K, Huyett P, Inala S, Ishman S, Jella T, Jobanputra A, Johnson A, Junna M, Kado J, Kaffenberger T, Kapur V, Kezirian E, Khan M, Kirsch D, Kominsky A, Kryger M, Krystal A, Kushida C, Kuzniar T, Lam D, Lettieri C, Lim D, Lin H, Liu S, MacKay S, Magalang U, Malhotra A, Mansukhani M, Maurer J, May A, Mitchell R, Mokhlesi B, Mullins A, Nada E, Naik S, Nokes B, Olson M, Pack A, Pang E, Pang K, Patil S, Van de Perck E, Piccirillo J, Pien G, Piper A, Plawecki A, Quigg M, Ravesloot M, Redline S, Rotenberg B, Ryden A, Sarmiento K, Sbeih F, Schell A, Schmickl C, Schotland H, Schwab R, Seo J, Shah N, Shelgikar A, Shochat I, Soose R, Steele T, Stephens E, Stepnowsky C, Strohl K, Sutherland K, Suurna M, Thaler E, Thapa S, Vanderveken O, de Vries N, Weaver E, Weir I, Wolfe L, Woodson B, Won C, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu J, Zeidler M, Rosen I. International Consensus Statement on Obstructive Sleep Apnea. International Forum Of Allergy & Rhinology 2023, 13: 1061-1482. PMID: 36068685, PMCID: PMC10359192, DOI: 10.1002/alr.23079.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apneaEvidence-based reviewPositive airway pressureInternational consensus statementSleep apneaConsensus statementAdult OSA patientsMultiple treatment modalitiesSleep apnea evaluationAirway pressureOSA patientsPAP adherenceSurgical treatmentEvidence-based practiceOSA treatmentLongitudinal careTreatment modalitiesClinical managementRisk factorsHealth risk outcomesStudy qualitySyndrome definitionCurrent evidenceRecommendation formatOSA disease
2018
Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography
Johnson KG, Johnson DC, Thomas RJ, Feldmann E, Lindenauer PK, Visintainer P, Kryger MH. Flow limitation/obstruction with recovery breath (FLOW) event for improved scoring of mild obstructive sleep apnea without electroencephalography. Sleep Medicine 2018, 67: 249-255. PMID: 30583916, PMCID: PMC6548700, DOI: 10.1016/j.sleep.2018.11.014.Peer-Reviewed Original ResearchConceptsApnea/hypopnea indexObstructive sleep apneaMild obstructive sleep apneaSleep apneaAirflow disruptionIntraclass correlationAHI categoriesBaseline PSGHypopnea indexOSA patientsHighest tertileOSA categoriesArousal criteriaPatientsFlow limitationApneaDesaturationFlow scoreArousal eventsOverall kappaObstructionTraining periodHigher proportionElectroencephalographyScoring0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea
Johnson K, Johnson D, Visintainer P, Kryger M, Thomas R, Linderauer P, Feldmann E. 0479 Novel Flow Limitation/Obstruction With Recovery Breath (FLOW) Event Identifies Obstructive Burden In Mild Obstructive Sleep Apnea. Sleep 2018, 41: a181-a181. DOI: 10.1093/sleep/zsy061.478.Peer-Reviewed Original ResearchMild obstructive sleep apneaObstructive sleep apneaHome sleep apnea testingRespiratory-related arousalsObstructive eventsSleep apneaMild OSA patientsApnea-hypopnea indexIdentification of patientsSleep apnea testingSeverity of diseaseFlow scoreOSA patientsApnea testingAdverse outcomesMild patientsPolysomnography studiesClinical significancePatientsSignificant gender differencesApneaDesaturationAirflow disruptionObstructionArousal data
2014
A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea
Mutter TC, Chateau D, Moffatt M, Ramsey C, Roos LL, Kryger M. A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea. Anesthesiology 2014, 121: 707-718. PMID: 25247853, DOI: 10.1097/aln.0000000000000407.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure therapyPositive airway pressure therapyObstructive sleep apneaAirway pressure therapySleep apneaPressure therapyOSA patientsCardiovascular complicationsPostoperative outcomesDiagnosis of OSAUndiagnosed obstructive sleep apneaAdult OSA patientsImportant risk modifiersPostoperative cardiovascular complicationsMatched Cohort StudyHealth administrative dataType of surgeryLarger efficacy trialPostoperative complicationsRespiratory complicationsCohort studyOSA severityPostoperative dayPreoperative diagnosisCardiac arrest
2003
Morbidity and mortality in obstructive sleep apnea syndrome 2: Effect of treatment on neuropsychiatric morbidity and quality of life
AL‐BARRAK M, SHEPERTYCKY M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 2: Effect of treatment on neuropsychiatric morbidity and quality of life. Sleep And Biological Rhythms 2003, 1: 65-74. DOI: 10.1046/j.1446-9235.2003.00008.x.Peer-Reviewed Original ResearchContinuous positive airway pressureQuality of lifeNeuropsychiatric problemsObstructive sleep apnea syndrome (OSA) resultsAutomobile accident ratesNocturnal oxygen desaturationPositive airway pressureFragmentation of sleepEffect of treatmentOxygen desaturationAirway pressureOSA patientsResidual abnormalitiesCommon presentationNeuropsychiatric sequelaeNeuropsychiatric morbidityNeuropsychiatric abnormalitiesElectroencephalographic arousalSyndrome 2Syndrome resultsPatientsLife issuesMorbidityOSASAbnormalitiesMorbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
SHEPERTYCKY M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
1999
Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment
Bahammam A, Delaive K, Ronald J, Manfreda J, Roos L, Kryger M. Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment. Sleep 1999, 22: 740-747. PMID: 10505819, DOI: 10.1093/sleep/22.6.740.Peer-Reviewed Original ResearchConceptsOSA patientsGeneral populationProspective observational cohort studyObservational cohort studySubgroup of patientsSleep disorders centerTreatment of patientsTwo yearsOSAS groupCohort studyPAT groupControl subjectsDisorders CenterPhysician claimsPatientsUtilization dataOne-yearDiagnosisYears one yearTreatmentYearsCanadian provincesOSASGroupHospitalHealth Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients
Ronald J, Delaive K, Roos L, Manfreda J, Bahammam A, Kryger M. Health Care Utilization in the 10 Years Prior to Diagnosis in Obstructive Sleep Apnea Syndrome Patients. Sleep 1999, 22: 225-229. PMID: 10201067, DOI: 10.1093/sleep/22.2.225.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndrome (OSAS) patientsSleep apnea syndrome patientsOSAS patientsSyndrome patientsHealth servicesHealth care utilizationHealth service utilizationInitial diagnostic evaluationHealth care resourcesHealth care servicesOvernight hospitalizationOSA patientsSuch patientsCare utilizationSleep apneaTime patientsRisk factorsService utilizationDiagnostic evaluationGeneral populationTobacco consumptionPatientsCare resourcesCare servicesAlcohol usage
1998
Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea
Wali S, Bahammam A, Massaeli H, Pierce G, Iliskovic N, Singal P, Kryger M. Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea. Sleep 1998, 21: 290-296. PMID: 9595608, DOI: 10.1093/sleep/21.3.290.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinObstructive sleep apneaOSA patientsNormal controlsOxidative stressSleep apneaPatient groupSevere hypoxiaSusceptibility of LDLFree radical challengeSame age groupCPAP therapySevere hypoxemiaRed blood cellsCardiovascular diseaseAntioxidant reserveGeneral populationPatientsIndividual low-density lipoproteinHours of exposureControl groupAge groupsGlutathione peroxidaseBlood cellsConjugated dienesObstructive sleep apnea patients use more health care resources ten years prior to diagnosis.
Ronald J, Delaive K, Roos L, Manfreda J, Kryger M. Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis. Sleep Research Online : SRO 1998, 1: 71-4. PMID: 11382859.Peer-Reviewed Original ResearchConceptsOSA patientsObstructive sleep apnea syndrome (OSAS) patientsHealth care utilization recordsPatient health care utilizationSleep apnea syndrome patientsObstructive sleep apnea patientsHealth care utilizationSleep apnea patientsOSAS patientsMore hospitalizationsCare utilizationApnea patientsOSAS diagnosisSyndrome patientsGeneral populationPatientsUtilization recordsTen yearsDiagnosisTen-year periodYearsTen-year intervalsComorbiditiesHospitalizationHeavy users
1997
Using Self-Reported Questionnaire Data to Prioritize OSA Patients for Polysomnography
Pouliot Z, Peters M, Neufeld H, Kryger M. Using Self-Reported Questionnaire Data to Prioritize OSA Patients for Polysomnography. Sleep 1997, 20: 232-236. PMID: 9178919, DOI: 10.1093/sleep/20.3.232.Peer-Reviewed Original ResearchConceptsBody mass indexEpworth Sleepiness ScaleObstructive sleep apneaSimple clinical dataPercent of casesAnalysis of receiverHundreds of patientsLow AIObserved apneaApnea indexOSA patientsConsecutive patientsSleep apneaMass indexSelf-reported questionnaire dataClinical dataSleepiness ScalePatientsApneaPolysomnographyCharacteristic curveQuestionnaire dataGroupQuestionnaireSubjects
1996
Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea
Kryger M, Roos L, Delaive K, Walld R, Horrocks J. Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea. Sleep 1996, 19: s111-s116. PMID: 9122567, DOI: 10.1093/sleep/19.suppl_9.s111.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHealth care servicesSleep apneaControl groupCare servicesSevere obstructive sleep apneaHealth care utilizationSleep apnea patientsObese patientsOSA patientsCare utilizationInitial diagnosisOSA groupControl subjectsApnea patientsHospital costsPhysician claimsPatientsApneaControl counterpartsHeavy consumersSpecific evaluationGroupTotal expenditureHospital
1995
Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders?
Yamashiro Y, Kryger M. Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders? Sleep 1995, 18: 167-171. PMID: 7610312, DOI: 10.1093/sleep/18.3.167.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeExcessive daytime sleepinessHome oximetrySleep disordersSevere OSA patientsTertiary referral hospitalPeriodic limb movementsSleep disorders centerNumber of desaturationsSleep-breathing disordersDisorders of sleepOxygen saturation dataMild OSAOSA patientsPolysomnographic diagnosisReferral hospitalSleep apneaResistance syndromeDaytime sleepinessDisorders CenterBlinded comparisonClinical diagnosisOximetryPolysomnographyPatients
1988
Mortality and Apnea Index in Obstructive Sleep Apnea Experience in 385 Male Patients
He J, Kryger M, Zorick F, Conway W, Roth T. Mortality and Apnea Index in Obstructive Sleep Apnea Experience in 385 Male Patients. CHEST Journal 1988, 94: 9-14. PMID: 3289839, DOI: 10.1378/chest.94.1.9.Peer-Reviewed Original ResearchConceptsApnea indexObstructive sleep apneaNasal CPAPOSA patientsCumulative survivalObstructive sleep apnea experienceEight-year survivalMale OSAS patientsUntreated OSA patientsGreater mortalityYears of ageUPPP patientsLatter patientsMale patientsSleep apneaPatientsSurvival curvesMortalityTracheostomyCPAPSurvivalIndexApneaUPPPTherapy