2024
Age modulates the predictive value of self-reported sleepiness for all-cause mortality risk: insights from a comprehensive national database of veterans.
Maghsoudi A, Azarian M, Sharafkhaneh A, Jones M, Nozari H, Kryger M, Ramezani A, Razjouyan J. Age modulates the predictive value of self-reported sleepiness for all-cause mortality risk: insights from a comprehensive national database of veterans. Journal Of Clinical Sleep Medicine 2024, 20: 1785-1792. PMID: 38935061, PMCID: PMC11530978, DOI: 10.5664/jcsm.11254.Peer-Reviewed Original ResearchExcessive daytime sleepinessEpworth Sleepiness ScaleCharlson Comorbidity IndexVeterans Health Administration dataHigher Epworth sleepiness scaleHealth administrative dataPhysician progress notesMeasure excessive daytime sleepinessIncreased all-cause mortalityAge-stratified analysesAll-cause mortalityComprehensive national databaseMean BMIProgress notesICD9/10 codesAdministrative dataComorbidity indexDaytime sleepinessOdds ratioMortality riskSleep servicesSleepiness ScaleSelf-reported sleepinessHigher ESSPredictive value
2019
The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy
Rosenberg R, Hirshkowitz M, Rapoport DM, Kryger M. The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy. Sleep Medicine 2019, 56: 80-89. PMID: 30803831, DOI: 10.1016/j.sleep.2019.01.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHome sleep apnea testingObstructive sleep apneaExcessive daytime sleepinessSleep disordersSleep apneaEvaluation of EDSLow cerebrospinal fluid (CSF) hypocretin (orexin) levelsCerebrospinal fluid hypocretin levelsEvaluation of patientsDifferential clinical characteristicsDiagnosis of narcolepsySleep apnea testingHome sleep testingClinical characteristicsExcessive daytimeHypocretin levelsSleep testingApnea testingConsensus guidelinesLaboratory polysomnographyNarcolepsy diagnosisDaytime sleepinessCommon complaintMedical conditionsSubstantial burden
2007
Cytokines and pathological sleep
Kapsimalis F, Basta M, Varouchakis G, Gourgoulianis K, Vgontzas A, Kryger M. Cytokines and pathological sleep. Sleep Medicine 2007, 9: 603-614. PMID: 18024171, DOI: 10.1016/j.sleep.2007.08.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMultiple biologic actionsObstructive sleep apneaExcessive daytime sleepinessNew biologic treatmentsChronic inflammatory diseaseHormonal regulatory mechanismsCardiovascular consequencesSleep apneaBiologic treatmentExcessive sleepinessSleep disturbancesDaytime sleepinessInflammatory diseasesSleep disordersCytokinesImmune systemBiologic actionsIntercellular mediatorsPathological sleepTarget tissuesSleepinessSleep lossImportant roleDisordersApnea
2004
Sleep, health, and aging. Bridging the gap between science and clinical practice.
Kryger M, Monjan A, Bliwise D, Ancoli-Israel S. Sleep, health, and aging. Bridging the gap between science and clinical practice. Geriatrics 2004, 59: 24-6, 29-30. PMID: 14755865.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExcessive daytime sleepinessPrevalence of insomniaProblems of sleepSlow-wave sleepQuality of lifeAdults age 65Age-related processesGeriatric populationDaytime sleepinessSleep disordersSleep efficiencyClinical practiceRestful sleepAge 65Depressed moodOlder populationSleepInsomniaLater lifeAdverse changesMemory problemsNight resultsComorbiditiesPopulationSleepiness
2003
Sleep Disorders in a Military Population
Pouliot Z, Peters M, Neufeld H, Delaive K, Kryger M. Sleep Disorders in a Military Population. Military Medicine 2003, 168: 7-10. PMID: 12546237, DOI: 10.1093/miled.168.1.7.Peer-Reviewed Original ResearchConceptsSleep breathing disordersSleep disordersMovement disordersMilitary populationExcessive daytime sleepinessSleep disorders centerMajority of referralsCanadian military personnelMilitary personnelCommon diagnosisBreathing disordersMean ageFull polysomnographyMilitary patientsSleep diagnosesDaytime sleepinessDisorders CenterNeurocognitive impairmentDisordersCivilian populationDiagnosisAgeGroupSDPopulation
1995
Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders?
Yamashiro Y, Kryger M. Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders? Sleep 1995, 18: 167-171. PMID: 7610312, DOI: 10.1093/sleep/18.3.167.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeExcessive daytime sleepinessHome oximetrySleep disordersSevere OSA patientsTertiary referral hospitalPeriodic limb movementsSleep disorders centerNumber of desaturationsSleep-breathing disordersDisorders of sleepOxygen saturation dataMild OSAOSA patientsPolysomnographic diagnosisReferral hospitalSleep apneaResistance syndromeDaytime sleepinessDisorders CenterBlinded comparisonClinical diagnosisOximetryPolysomnographyPatients