2024
Age modulates the predictive value of self-reported sleepiness for all-cause mortality risk: insights from a comprehensive national database of veterans.
Maghsoudi A, Azarian M, Sharafkhaneh A, Jones M, Nozari H, Kryger M, Ramezani A, Razjouyan J. Age modulates the predictive value of self-reported sleepiness for all-cause mortality risk: insights from a comprehensive national database of veterans. Journal Of Clinical Sleep Medicine 2024, 20: 1785-1792. PMID: 38935061, PMCID: PMC11530978, DOI: 10.5664/jcsm.11254.Peer-Reviewed Original ResearchExcessive daytime sleepinessEpworth Sleepiness ScaleCharlson Comorbidity IndexVeterans Health Administration dataHigher Epworth sleepiness scaleHealth administrative dataPhysician progress notesMeasure excessive daytime sleepinessIncreased all-cause mortalityAge-stratified analysesAll-cause mortalityComprehensive national databaseMean BMIProgress notesICD9/10 codesAdministrative dataComorbidity indexDaytime sleepinessOdds ratioMortality riskSleep servicesSleepiness ScaleSelf-reported sleepinessHigher ESSPredictive value
2019
The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy
Rosenberg R, Hirshkowitz M, Rapoport DM, Kryger M. The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy. Sleep Medicine 2019, 56: 80-89. PMID: 30803831, DOI: 10.1016/j.sleep.2019.01.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHome sleep apnea testingObstructive sleep apneaExcessive daytime sleepinessSleep disordersSleep apneaEvaluation of EDSLow cerebrospinal fluid (CSF) hypocretin (orexin) levelsCerebrospinal fluid hypocretin levelsEvaluation of patientsDifferential clinical characteristicsDiagnosis of narcolepsySleep apnea testingHome sleep testingClinical characteristicsExcessive daytimeHypocretin levelsSleep testingApnea testingConsensus guidelinesLaboratory polysomnographyNarcolepsy diagnosisDaytime sleepinessCommon complaintMedical conditionsSubstantial burden
2015
The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea
Javaheri S, Winslow D, McCullough P, Wylie P, Kryger MH. The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea. CHEST Journal 2015, 148: 1454-1461. PMID: 25950507, DOI: 10.1378/chest.14-2966.Peer-Reviewed Original ResearchConceptsCentral apnea indexApnea-hypopnea indexCentral sleep apneaSleep apneaSleep qualityComplex sleep-disordered breathingASV deviceASV titrationAdaptive servoventilation devicesCongestive heart failureMonths of treatmentSleep-disordered breathingEpworth Sleepiness ScaleLong-term treatmentImproved sleep qualityMixed sleep apneaBetter sleep qualityApnea indexHeart failureObservational trialObstructive apneaBreathing disordersInspiratory pressureArousal indexDaytime sleepiness
2011
A Novel Nasal Expiratory Positive Airway Pressure (EPAP) Device for the Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial
Berry RB, Kryger MH, Massie CA. A Novel Nasal Expiratory Positive Airway Pressure (EPAP) Device for the Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial. Sleep 2011, 34: 479-485. PMID: 21461326, PMCID: PMC3065258, DOI: 10.1093/sleep/34.4.479.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPositive airway pressure devicesSleep apneaSham deviceWeek 1Double-blind clinical trialSevere obstructive sleep apneaMonths of treatmentSleep disorders centerEpworth Sleepiness ScalePressure deviceSubjective daytime sleepinessNon-consecutive nightsControlled TrialsMonth 3Sham treatmentClinical trialsDaytime sleepinessITT groupDisorders CenterSleepiness ScaleAHI valuesApneaMedian percentageAHI
2009
Sleep Breathing Disorders in the U.S. Female Population
Kapsimalis F, Kryger M. Sleep Breathing Disorders in the U.S. Female Population. Journal Of Women's Health 2009, 18: 1211-1219. PMID: 19627224, PMCID: PMC2825714, DOI: 10.1089/jwh.2008.1054.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeU.S. female populationHigh riskBerlin questionnaireFemale populationCommon symptomsDaytime sleepinessMedical disordersPrimary care medical communityRestless legs syndrome symptomsChronic medical disordersSleep apnea syndromeSleep breathing disordersMenstrual cycle statusSleep onset insomniaSuch common symptomsNational Sleep FoundationAnnual telephone surveyHabitual snoringApnea syndromeBreathing disordersPostpartum womenCommon disorderSyndrome symptomsOnset insomnia
2007
Cytokines and pathological sleep
Kapsimalis F, Basta M, Varouchakis G, Gourgoulianis K, Vgontzas A, Kryger M. Cytokines and pathological sleep. Sleep Medicine 2007, 9: 603-614. PMID: 18024171, DOI: 10.1016/j.sleep.2007.08.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMultiple biologic actionsObstructive sleep apneaExcessive daytime sleepinessNew biologic treatmentsChronic inflammatory diseaseHormonal regulatory mechanismsCardiovascular consequencesSleep apneaBiologic treatmentExcessive sleepinessSleep disturbancesDaytime sleepinessInflammatory diseasesSleep disordersCytokinesImmune systemBiologic actionsIntercellular mediatorsPathological sleepTarget tissuesSleepinessSleep lossImportant roleDisordersApneaSleep apnea: Clinical investigations in humans
Banno K, Kryger MH. Sleep apnea: Clinical investigations in humans. Sleep Medicine 2007, 8: 400-426. PMID: 17478121, DOI: 10.1016/j.sleep.2007.03.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeCentral sleep apnea syndromeContinuous positive airway pressureSleep apnea syndromeApnea syndromeApneic episodesTreatment of OSASDiagnosis of SASUpper airway obstructionPositive airway pressureMuscles of respirationCessation of breathingCentral nervous systemAirway obstructionAirway pressureHeart failureOral appliancesRespiratory driveImpaired qualityAbnormal breathingSubjective symptomsDaytime sleepinessCommon disorderMetabolic dysfunctionSleep disruption
2005
Experience in using split-day studies for suspected obstructive sleep apnea syndrome
Banno K, Al Sabbagh A, Delaive K, Higami S, Kryger MH. Experience in using split-day studies for suspected obstructive sleep apnea syndrome. Respiratory Medicine 2005, 99: 1334-1339. PMID: 16140233, DOI: 10.1016/j.rmed.2005.02.030.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeSleep breathing disordersApnea syndromeInconclusive studiesSevere obstructive sleep apnea syndromeSevere daytime sleepinessEligible casesBreathing disordersDefinitive diagnosisFinal diagnosisDaytime sleepinessMovement disordersSleep disordersSleep studiesPatientsSleep deprivationDiagnosisSubjective sleepinessAdditional assessmentDisordersInsufficient dataSyndromeSleepinessConclusive studies
2004
Sleep, health, and aging. Bridging the gap between science and clinical practice.
Kryger M, Monjan A, Bliwise D, Ancoli-Israel S. Sleep, health, and aging. Bridging the gap between science and clinical practice. Geriatrics 2004, 59: 24-6, 29-30. PMID: 14755865.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExcessive daytime sleepinessPrevalence of insomniaProblems of sleepSlow-wave sleepQuality of lifeAdults age 65Age-related processesGeriatric populationDaytime sleepinessSleep disordersSleep efficiencyClinical practiceRestful sleepAge 65Depressed moodOlder populationSleepInsomniaLater lifeAdverse changesMemory problemsNight resultsComorbiditiesPopulationSleepiness
2003
Sleep Disorders in a Military Population
Pouliot Z, Peters M, Neufeld H, Delaive K, Kryger M. Sleep Disorders in a Military Population. Military Medicine 2003, 168: 7-10. PMID: 12546237, DOI: 10.1093/miled.168.1.7.Peer-Reviewed Original ResearchConceptsSleep breathing disordersSleep disordersMovement disordersMilitary populationExcessive daytime sleepinessSleep disorders centerMajority of referralsCanadian military personnelMilitary personnelCommon diagnosisBreathing disordersMean ageFull polysomnographyMilitary patientsSleep diagnosesDaytime sleepinessDisorders CenterNeurocognitive impairmentDisordersCivilian populationDiagnosisAgeGroupSDPopulation
2001
Radiofrequency tissue reduction of the palate in patients with moderate sleep-disordered breathing.
Brown D, Kerr P, Kryger M. Radiofrequency tissue reduction of the palate in patients with moderate sleep-disordered breathing. Journal Of Otolaryngology 2001, 30: 193-8. PMID: 11771028, DOI: 10.2310/7070.2001.19696.Peer-Reviewed Original ResearchConceptsModerate sleep-disordered breathingSleep-disordered breathingApnea-hypopnea indexMild sleep-disordered breathingRadiofrequency tissue ablationRadiofrequency tissue reductionSt. Boniface HospitalClinically significant differencesResponse to treatmentEpworth Sleepiness ScalePost-treatment groupSoft palate tissueApnea-HypopneaArousal indexClinical efficacyEffects of treatmentPalatal tissueSoft palateFollow-upTissue reductionDaytime sleepinessRadiofrequency energySleepiness ScalePatientsSleep parameters
1995
Sleep complaints are common in a dialysis unit
Walker S, Fine A, Kryger M. Sleep complaints are common in a dialysis unit. American Journal Of Kidney Diseases 1995, 26: 751-756. PMID: 7485127, DOI: 10.1016/0272-6386(95)90438-7.Peer-Reviewed Original ResearchConceptsRestless legs syndromeSleep-wake complaintsSpecific sleep disordersCreatinine levelsDialysis patientsLegs syndromeSleep apneaUremic patientsFrequent awakeningsImpaired qualitySleep complaintsSleep QuestionnaireHemodialysis unitDaytime sleepinessDisturbed sleepMale genderDialysis unitsCaffeine intakeClinical significanceSleep disordersSleep problemsFrequent complaintPatientsSpecific complaintsActual prevalenceA Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient
Yamashiro Y, Chodirker B, Hobson D, Kryger M. A Familial Awake Movement Disorder Mimicking Restless Legs in a Sleep Apnea Patient. Sleep 1995, 18: 604-607. PMID: 8552932, DOI: 10.1093/sleep/18.7.604.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMovement disordersFamilial movement disordersLegs syndromeSleep apneaNasal continuous positive airway pressureContinuous positive airway pressurePositive airway pressureObstructive sleep apneaPeriodic limb movementsSleep apnea syndromeSleep apnea patientsSleep onset insomniaSupine posturingAirway pressureObese menApnea syndromeLeg sensationsRestless legsNocturnal arousalsMean durationApnea patientsDaytime sleepinessSuccessful treatmentClinical significanceNocturnal Oximetry: Is It a Screening Tool for Sleep Disorders?
Yamashiro Y, Kryger M. Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders? Sleep 1995, 18: 167-171. PMID: 7610312, DOI: 10.1093/sleep/18.3.167.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeExcessive daytime sleepinessHome oximetrySleep disordersSevere OSA patientsTertiary referral hospitalPeriodic limb movementsSleep disorders centerNumber of desaturationsSleep-breathing disordersDisorders of sleepOxygen saturation dataMild OSAOSA patientsPolysomnographic diagnosisReferral hospitalSleep apneaResistance syndromeDaytime sleepinessDisorders CenterBlinded comparisonClinical diagnosisOximetryPolysomnographyPatients
1992
The Effect of Short-term Nasal CPAP on Cheyne-Stokes Respiration in Congestive Heart Failure
Buckle P, Millar T, Kryger M. The Effect of Short-term Nasal CPAP on Cheyne-Stokes Respiration in Congestive Heart Failure. CHEST Journal 1992, 102: 31-35. PMID: 1623779, DOI: 10.1378/chest.102.1.31.Peer-Reviewed Original ResearchConceptsCongestive heart failureCheyne-Stokes respirationMultiple sleep latency testNasal CPAPSleep qualityNocturnal oxygenationHeart failureTreatment nightsDaytime arterial blood gas valuesArterial blood gas valuesNasal CPAP therapyNYHA class 3Sleep latency testBlood gas valuesShort-term treatmentSignificant differencesAge 54.1CPAP therapyMale patientsFull polysomnographyDaytime sleepinessLatency testCPAPPatientsGas values