2011
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development
Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. Journal Of Cell Science 2011, 124: 3428-3440. PMID: 21984813, PMCID: PMC3196857, DOI: 10.1242/jcs.083659.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBone DevelopmentBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Cell DifferentiationCell Growth ProcessesCells, CulturedChondrocytesCore Binding Factor Alpha 1 SubunitCyclin-Dependent Kinase 4Gene Expression RegulationGrowth PlateMiceMice, KnockoutOsteochondrodysplasiasProtein Processing, Post-TranslationalSignal TransductionConceptsEndochondral bone developmentBMP4 geneCartilage developmentDeletion of Bmp2Post-transcriptional levelRunx2 protein levelsBone developmentChondrocyte proliferationChondrodysplasia phenotypeProteasomal degradationBMP2 geneGenetic controlKey regulatorConditional knockout miceMolecular mechanismsKnockout miceBMP2Chondrocyte differentiationGenesGrowth plate chondrocytesRunx2 expressionCartilage phenotypeSpecific functionsProfound defectsNovel insights
2008
Regulation of embryonic endochondral ossification by Smurf2
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. Regulation of embryonic endochondral ossification by Smurf2. Journal Of Orthopaedic Research® 2008, 26: 704-712. PMID: 18176945, PMCID: PMC2636972, DOI: 10.1002/jor.20563.Peer-Reviewed Original ResearchConceptsOverexpression of Smurf2Embryonic endochondral ossificationChondrocyte maturationTGF-beta receptorsEndochondral ossificationTGF-beta signalingGrowth plate chondrocytesPrimary articular chondrocytesHistological analysisSmurf2 expressionChick growth plateGrowth plateHypertrophic differentiationMaturational stagesType X collagenLong bonesMRNA levelsSmurf2 levelsOssificationProliferative stageArticular chondrocytesChondrocytesSmurf2X collagenEctopic overexpression