1993
7-Benzylidenenaltrexone (BNTX): A selective δ1 opioid receptor antagonist in the mouse spinal cord
Sofuoglu M, Portoghese P, Takemori A. 7-Benzylidenenaltrexone (BNTX): A selective δ1 opioid receptor antagonist in the mouse spinal cord. Life Sciences 1993, 52: 769-775. PMID: 8383271, DOI: 10.1016/0024-3205(93)90240-4.Peer-Reviewed Original ResearchConceptsAntinociceptive ED50 valueDELT IIED50 valuesDelta opioid receptor subtypesOpioid receptor subtypesDelta-opioid receptorsSubtype-selective agonistsAntinociceptive ED50Spinal sitesOpioid receptorsReceptor subtypesSelective agonistBNTXDPDPEMiceAdministrationHand administrationAntinociceptionRecent reportsDAMGONaltribenMorphineAgonistsAntagonistED50
1992
Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine
Sofuoglu M, Portoghese P, Takemori A. Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine. European Journal Of Pharmacology 1992, 210: 159-162. PMID: 1318206, DOI: 10.1016/0014-2999(92)90666-r.Peer-Reviewed Original ResearchConceptsMorphine injectionSelective kappa opioid antagonistED50 valuesKappa-opioid antagonistAcute morphine toleranceTail-flick assayDevelopment of toleranceKappa-opioid sitesAntinociceptive ED50 valueNon-pretreated controlsSupraspinal sitesOpioid toleranceMorphine administrationControl miceMorphine sulfateMorphine toleranceOpioid agonistsOpioid antagonistSpinal sitesSingle doseOpioid receptorsOpioid sitesMorphineMiceSelective blockage
1991
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Sofuoglu M, Portoghese P, Takemori A. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 676-80. PMID: 1851833.Peer-Reviewed Original ResearchConceptsAntinociceptive ED50Antinociceptive actionMorphine sulfateAntinociceptive assaysDelta-opioid receptor agonistDelta opioid receptor subtypesDelta-opioid subtypesOpioid receptor agonistsOpioid receptor subtypesSingle large doseDelta-opioid agonistsPretreatment of animalsOpioid subtypesOpioid agonistsSpinal sitesDifferential antagonismReceptor agonistReceptor subtypesAntinociceptive activityD-Ala2Large doseDSLETDPDPENaltrindoleAntagonist activity
1990
Naloxone produces protracted tolerance in mice treated with a single dose of morphine.
Sofuoglu M, Takemori A. Naloxone produces protracted tolerance in mice treated with a single dose of morphine. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 836-40. PMID: 2395115.Peer-Reviewed Original Research