Naloxone produces protracted tolerance in mice treated with a single dose of morphine.
Sofuoglu M, Takemori A. Naloxone produces protracted tolerance in mice treated with a single dose of morphine. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 836-40. PMID: 2395115.Peer-Reviewed Original ResearchMaintenance of morphine dependence by naloxone in acutely dependent mice.
Sofuoglu M, Sato J, Takemori A. Maintenance of morphine dependence by naloxone in acutely dependent mice. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 841-6. PMID: 2395116.Peer-Reviewed Original ResearchConceptsMorphine sulfateNaloxone hydrochloridePriming doseED50 valuesSingle doseControl groupMorphine-pretreated miceOpioid antagonist naloxoneSigns of withdrawalDevelopment of dependenceMS injectionDependent miceAntagonist naloxoneMorphine dependenceMiceDoseFormer groupMS 24NaloxoneHrPretreatmentWithdrawalInjectionGroupDays