2024
Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications
Talcott W, Marta G, Moran M. Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications. Advances In Radiation Oncology 2024, 9: 101569. PMID: 39188995, PMCID: PMC11345291, DOI: 10.1016/j.adro.2024.101569.Peer-Reviewed Original ResearchPost-operative radiationNipple-sparing mastectomyRegional nodal irradiationAdverse pathologic featuresOverall survivalPathological featuresEarly-stage breast cancerNational Cancer DatabasePost-operative settingType of surgeryHigh-risk subgroupsNipple preservationNodal irradiationPN+ ratePositive marginsRadiation deliveryInvasive carcinomaSurgical subtypesCancer DatabaseLymph nodesPatient selectionPN+Breast cancerCox regressionMultivariate analysis
2023
Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Pellegrini C, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Shiloh R, Taghian A, Warren L, Wright J, Chun Y, Punglia R. Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e3-e4. DOI: 10.1016/j.ijrobp.2023.08.029.Peer-Reviewed Original ResearchPreoperative endocrine therapyCW toxicityEndocrine therapyQuality-of-lifeLymph nodesHF-PMRTRadiation therapyBreast reconstructionRandomized trialsResults Median follow-upChest wallTissue expanderImplant-based breast reconstructionImmediate prosthetic reconstructionPostmastectomy radiation therapyCompare quality-of-lifeMedian follow-upImplant-based reconstructionPost-operative infectionPlacement of tissue expandersMulticenter randomized trialQuality-of-life scoresSide effects of treatmentStage 0-III breast cancerPhysical well-being scores
2021
CLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated
Peters G, Gao S, Knowlton C, Zhang A, Evans S, Higgins S, Wilson L, Saltmarsh N, Picone M, Moran M. CLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated. Journal Of The National Comprehensive Cancer Network 2021, 19: clo21-025. DOI: 10.6004/jnccn.2020.7707.Peer-Reviewed Original Research
2012
Basal Subtype, as Approximated by Triple Negative Phenotype, is Associated With Locoregional Recurrence in a Case-control Study of Women With 0-3 Positive Lymph Nodes After Mastectomy
Khan A, Milgrom S, Barnard N, Higgins S, Moran M, Kim S, Goyal S, Alfaraj F, Haffty B. Basal Subtype, as Approximated by Triple Negative Phenotype, is Associated With Locoregional Recurrence in a Case-control Study of Women With 0-3 Positive Lymph Nodes After Mastectomy. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s141. DOI: 10.1016/j.ijrobp.2012.07.165.Peer-Reviewed Original Research
2011
Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes
Castrucci W, Lannin D, Haffty BG, Higgins SA, Moran MS. Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes. International Scholarly Research Notices 2011, 2011: 874814. PMID: 22084784, PMCID: PMC3200302, DOI: 10.5402/2011/874814.Peer-Reviewed Original ResearchHigher nodal ratioBreast conservation therapyNodal ratioLymph nodesRegional recurrenceConservation therapyRegional failureN2/N3 patientsPositive axillary lymph nodesPositive lymph nodesAxillary lymph nodesGroup of patientsIntensive systemic therapyN3 statusDistant failureN3 patientsNodal recurrenceSystemic therapyDose escalationEntire cohortRegional nodesBreast cancerInclusion criteriaPrognostic variablesHigh riskBreast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival
Moran MS, Gonsalves L, Goss DM, Ma S. Breast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival. Breast Cancer Research And Treatment 2011, 128: 543-551. PMID: 21301957, PMCID: PMC3235412, DOI: 10.1007/s10549-011-1362-0.Peer-Reviewed Original ResearchConceptsBreast conservation surgeryAge-adjusted incidenceBreast cancerAdjuvant radiationNHW womenInvasive diseaseHormone receptor-negative diseaseFemale breast cancer patientsNon-Hispanic white womenPost-mastectomy RTRates of breastClinical-pathologic featuresInvolved lymph nodesPercentage of patientsReceptor-negative diseasePost-mastectomy radiationBreast cancer mortalityBreast cancer patientsLarger tumor sizeYounger median ageRelative survival ratesSignificant differencesMultivariate regression analysisSEER databaseLymph nodes
2008
Long‐term outcomes and clinicopathologic differences of African‐American versus white patients treated with breast conservation therapy for early‐stage breast cancer
Moran MS, Yang Q, Harris LN, Jones B, Tuck DP, Haffty BG. Long‐term outcomes and clinicopathologic differences of African‐American versus white patients treated with breast conservation therapy for early‐stage breast cancer. Cancer 2008, 113: 2565-2574. PMID: 18816610, DOI: 10.1002/cncr.23881.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma, MucinousAdultAntineoplastic AgentsBlack or African AmericanBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCohort StudiesCombined Modality TherapyFemaleFollow-Up StudiesHumansLymph NodesLymphatic MetastasisMastectomyNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapy DosageSurvival RateTreatment OutcomeWhite PeopleConceptsBreast conservation therapyLymph node recurrenceAA patientsWhite patientsAA womenNode recurrenceConservation therapyClinicopathologic differencesEarly-stage breast cancerChemotherapy/radiotherapyEarly-stage diseaseSurgical margin statusLong-term outcomesP53 expression statusBreast recurrenceOverall survivalIndependent predictorsLocal recurrenceLymph nodesMargin statusClinicopathologic featuresDistant metastasisN classificationMore estrogenBreast cancer
2007
Using Nodal Ratios to Predict the Risk of In-Field Regional Recurrences in Patients Treated With Breast Conservation Therapy in Patients With 4 or More Positive Lymph Nodes
Castrucci W, Haffty B, Moran M. Using Nodal Ratios to Predict the Risk of In-Field Regional Recurrences in Patients Treated With Breast Conservation Therapy in Patients With 4 or More Positive Lymph Nodes. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s212. DOI: 10.1016/j.ijrobp.2007.07.1179.Peer-Reviewed Original Research