Hypothalamic Pomc ‐deficiency Impairs the Function of Leptin to Decrease Food Intake and Bodyweight
Chhabra K, Adams J, Jones G, Rubinstein M, Low M. Hypothalamic Pomc ‐deficiency Impairs the Function of Leptin to Decrease Food Intake and Bodyweight. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1293.4.Peer-Reviewed Original ResearchFunction of leptinHistory of obesityNormal body weightPlasma leptin levelsKO miceFood intakeHypothalamic POMCBody weightLeptin levelsLeptin administrationLeptin sensitivityHigher plasma leptin levelsLeptin receptor gene expressionIntracerebroventricular leptin administrationMagnitude of obesityPomc knockout miceReversal of obesityWeight-matched miceDiabetes Research CenterNormal energy homeostasisWeight-matched groupsLongitudinal studyReceptor gene expressionARC POMCPrevents obesity