2019
Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism
Miorin L, Laurent-Rolle M, Pisanelli G, Co PH, Albrecht RA, García-Sastre A, Morrison J. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism. Journal Of Virology 2019, 93: 10.1128/jvi.00151-19. PMID: 31043530, PMCID: PMC6600188, DOI: 10.1128/jvi.00151-19.Peer-Reviewed Original Research
2014
The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon
Laurent-Rolle M, Morrison J, Rajsbaum R, Macleod JML, Pisanelli G, Pham A, Ayllon J, Miorin L, Martínez-Romero C, tenOever BR, García-Sastre A. The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon. Cell Host & Microbe 2014, 16: 314-327. PMID: 25211074, PMCID: PMC4176702, DOI: 10.1016/j.chom.2014.07.015.Peer-Reviewed Original Research
2005
Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses
Muñoz-Jordán JL, Laurent-Rolle M, Ashour J, Martínez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A. Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses. Journal Of Virology 2005, 79: 8004-8013. PMID: 15956546, PMCID: PMC1143737, DOI: 10.1128/jvi.79.13.8004-8013.2005.Peer-Reviewed Original ResearchConceptsSignal peptideCleavable signal peptidePositive-strand RNA virusesInterferon-stimulated response element promoterISRE promoter activationNonstructural protein NS4BB fusion proteinFunction of NS4BResponse element promoterActivation of STAT1Dengue virus NS4BNS2B/NS3Alpha/beta interferonAnti-interferon functionDeletion analysisIFN antagonismN-terminusPromoter activationFusion proteinStructural proteinsNonstructural proteinsInhibition of interferonRNA virusesViral polyprotein processingNS4B protein