2005
Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses
Muñoz-Jordán JL, Laurent-Rolle M, Ashour J, Martínez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A. Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses. Journal Of Virology 2005, 79: 8004-8013. PMID: 15956546, PMCID: PMC1143737, DOI: 10.1128/jvi.79.13.8004-8013.2005.Peer-Reviewed Original ResearchConceptsSignal peptideCleavable signal peptidePositive-strand RNA virusesInterferon-stimulated response element promoterISRE promoter activationNonstructural protein NS4BB fusion proteinFunction of NS4BResponse element promoterActivation of STAT1Dengue virus NS4BNS2B/NS3Alpha/beta interferonAnti-interferon functionDeletion analysisIFN antagonismN-terminusPromoter activationFusion proteinStructural proteinsNonstructural proteinsInhibition of interferonRNA virusesViral polyprotein processingNS4B protein
2003
Inhibition of interferon signaling by dengue virus
Muñoz-Jordán J, Sánchez-Burgos GG, Laurent-Rolle M, García-Sastre A. Inhibition of interferon signaling by dengue virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14333-14338. PMID: 14612562, PMCID: PMC283592, DOI: 10.1073/pnas.2335168100.Peer-Reviewed Original ResearchConceptsPositive-strand RNA genomeExpression of NS4BPositive-strand RNA virusesNuclear signal transducerVirus-encoded proteinsStrand RNA virusesStrand RNA genomeHuman A549 cellsDengue virusRNA genomeDengue virus-infected cellsSignal transducerTranscription 1Gene expressionUnknown functionVirus-infected cellsInhibition of interferonRNA virusesDengue virus infectionNS4BMosquito-borne flavivirusProteinA549 cellsIFN responseViral products